A short review of cell genomics
This special issue belongs to
|International Journal of Cell Biology and Cellular Processes|
Deadline for Manuscript Submission
|March 31st, 2022|
Deadline for Publication
|April 15, 2022|
Special Issue Description
The little amounts of DNA and RNA present in a single cell may now be sequenced thanks to developments in whole-genome and whole-transcriptome amplification. This opens a window into the scope and nature of genomic and transcriptomic heterogeneity that occurs in both healthy development and sickness. Our ability to comprehend the scope of genomic, epigenomic and transcriptome variability that occurs throughout an individual organism's lifetime will be revolutionized by single-cell techniques. Here, we review the important scientific and technical advances made, discuss the difficulties still facing us, and offer a preview of what the near future may hold. A key component of biology is the cell, which is where the genome's blueprint is converted into biological form and function. Nearly all of our present knowledge of the genome and its control comes from population-level research, which often involves the mass analysis of thousands or millions of cells. Although helpful, the resulting analysis frequently ignores any variability that exists within the population of cells.
Although it is generally believed that the genome is stable throughout normal development, there is a very small chance that a genetic mutation will occur with every cell cycle. Genomic heterogeneity, also known as somatic variation, will exist within the organism over a significant number of divisions. Recent investigations have found unexpectedly high levels of genomic variation in normal and diseased tissue, indicating higher rates of genetic damage than previously anticipated, even though such variation is at the core of many illnesses, including cancer. Still, little is understood about the nature and rate of DNA mutation, as well as how genetic makeup, lifestyle, and a variety of other factors affect these
* Genetic mutation
* Genetic makeup
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