Long non-coded RNA, cancer, immune cells, tumor micro-environment, immuno-oncology, immune escape, cancer-immune cycle, lncRNA signature

Year : 2024 | Volume :14 | Issue : 01 | Page : 7-26

Tshetiz Dahal

Prabhat Moktan

  1. General Physician Lugansk State Medical University Lypnia St. Rivne Ukraine
  2. Researcher Public Health District Hospital Singtam Sikkim India


Developing data from current research reveals fresh insights into the roles played by long non-coding RNAs (lncRNAs) in immuno-oncology. Long non-coding RNAs (lncRNAs) not only influence the aggressiveness of cancer cells but also play a crucial role in controlling different immune cells and stromal cells, which in turn changes the tumor micro-environment and impacts anti-tumor immunity. The significance of predictive indicators derived from long non-coding RNAs (lncRNAs) is underscored by insightful discoveries concerning their involvement in immuno-oncological activities. In this context, we offer a comprehensive overview detailing the diverse functions of lncRNAs originating from immune, tumor, and stromal cells within the tumor microenvironment. We delve into elucidating their intricate processes and functional characteristics, particularly concerning immuno-oncological activities. Additionally, we explore the advantages and drawbacks associated with employing single-cell-based technologies to investigate the mechanisms underlying immune-related lncRNAs in cellular contexts. Through this comprehensive analysis, we aim to shed light on the complex interplay between lncRNAs and the immune system in the context of cancer, providing valuable insights for advancing therapeutic strategies and precision medicine approaches.

Keywords: Long non-coded RNA, cancer, immune cells, tumor micro-environment, immuno-oncology, immune escape, cancer-immune cycle, lncRNA signature

[This article belongs to Research & Reviews : A Journal of Immunology(rrjoi)]

How to cite this article: Tshetiz Dahal, Prabhat Moktan. Long non-coded RNA, cancer, immune cells, tumor micro-environment, immuno-oncology, immune escape, cancer-immune cycle, lncRNA signature. Research & Reviews : A Journal of Immunology. 2024; 14(01):7-26.
How to cite this URL: Tshetiz Dahal, Prabhat Moktan. Long non-coded RNA, cancer, immune cells, tumor micro-environment, immuno-oncology, immune escape, cancer-immune cycle, lncRNA signature. Research & Reviews : A Journal of Immunology. 2024; 14(01):7-26. Available from: https://journals.stmjournals.com/rrjoi/article=2024/view=144248


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Regular Issue Subscription Review Article
Volume 14
Issue 01
Received March 11, 2024
Accepted March 14, 2024
Published April 24, 2024