International Journal of Biochemistry and Biomolecule Research

Editors Overview

ijbbr maintains an Editorial Board of practicing researchers from around the world, to ensure manuscripts are handled by editors who are experts in the field of study.

Open Access
Special Issue
Topic

Glucose Metabolism in Cardiac Disease

Abstract Submission Deadline : November 30, 2023

Manuscript Submission Deadline : December 25, 2023

Special Issue Description

Heart failure has been identified as an emerging epidemic and is one of the leading causes of death worldwide. Heart failure is a major economic and healthcare burden, with a 5-year survival rate of 50%. Despite broad interests and pressing clinical needs, our understanding of heart failure remains limited. As a result, there is no current cure. The heart is an omnivore, constantly consuming fuel and utilizing any substrate available. High rates of ATP production and turnover are essential for maintaining cardiac contractility and delivering blood and oxygen to other organs. Normal cardiac ATP is primarily derived from fatty acid oxidation (FAO), with glucose metabolism contributing less. However, under stressful conditions, FAO may be reduced, resulting in increased glucose utilization. Glucose transporters (GLUTs) mediate glucose uptake in cardiomyocytes, with GLUT1 and GLUT4 being the most abundant isoforms. The high rates of ATP production and turnover are critical in maintaining cardiac contractility to deliver blood and oxygen to the other organs. Under normal conditions, cardiac ATP is mainly derived from fatty acid (FA) oxidation (FAO), with glucose metabolism contributing less. In CHF, sympathetic system activation not only increases insulin resistance but also decreases insulin release from pancreatic beta cells, increases hepatic glucose production by stimulating both gluconeogenesis and glycogenolysis, and increases glucagon production and lipolysis.

Keywords

Gluconeogenesis , Glycogenolysis , ATP , Glucose , Glucose transporters

Manuscript Submission information

Manuscripts should be submitted online via the manuscript Engine. Once you register on APID, click here to go to the submission form. Manuscripts can be submitted until the deadline.
All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the email address:[email protected] for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a Double-blind peer-review process. A guide for authors and other relevant information for the submission of manuscripts is available on the Instructions for Authors page.

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