Rahul Sharma,
Sunil Shastri,
Sanjeev Acharya,
- Assistant Professor, Department of Pharmaceutics, Ganpat University – Institute of Pharmacy, Ganpat Vidyanagar, Mehsana, Gujarat, India
- Assistant Professor, Department of Pharmaceutics, Ganpat University – Institute of Pharmacy, Ganpat Vidyanagar, Mehsana, Gujarat, India
- Assistant Professor, Department of Pharmaceutics, Ganpat University – Institute of Pharmacy, Ganpat Vidyanagar, Mehsana, Gujarat, India
Abstract
iomedical applications, drug delivery, hydrogels, smart hydrogels, tissue engineering
Keywords: iomedical applications, drug delivery, hydrogels, smart hydrogels, tissue engineering
[This article belongs to Trends in Drug Delivery ]
Rahul Sharma, Sunil Shastri, Sanjeev Acharya. Hydrogels: Innovations, Applications, and Future Directions in Biomedical Research. Trends in Drug Delivery. 2025; 12(03):17-27.
Rahul Sharma, Sunil Shastri, Sanjeev Acharya. Hydrogels: Innovations, Applications, and Future Directions in Biomedical Research. Trends in Drug Delivery. 2025; 12(03):17-27. Available from: https://journals.stmjournals.com/tdd/article=2025/view=236143
References
1. Bahram M, Mohseni N, Moghtader M. An introduction to hydrogels and some recent applications. In: Emerging Concepts in Analysis and Applications of Hydrogels. In: TechOpen; 2016. p. 9–38.
2. Bordbar-Khiabani A, Gasik M. Smart hydrogels for advanced drug delivery systems. Int J Mol Sci. 2022;23(7):3665.
3. Talebian S, Mehrali M, Taebnia N, Pennisi CP, Kadumudi FB, Foroughi J, et al. Self-healing hydrogels: The next paradigm shift in tissue engineering? Adv Sci. 2019;6(16):1801664.
4. Sirousazar M, Forough M, Farhadi K, Shaabani Y, Molaei R. Hydrogels: Properties, preparation, characterization and biomedical applications in tissue engineering, drug delivery and wound care. In: Tiwari A, editor. Advanced Healthcare Materials. Scrivener Publishing; 2014. p. 295–358.
5. Zhao Y, Wang X, Qi R, Yuan H. Recent advances of natural-polymer-based hydrogels for wound antibacterial therapeutics. Polymers. 2023;15(15):3305.
6. Garg S, Garg A. Hydrogel: classification, properties, preparation and technical features. Asian J Biomater Res. 2016;2(6):163–70.
7. Gulrez SKH, Al-Assaf S, Phillips GO. Hydrogels: Methods of preparation, characterisation and applications. In: Carpi A, editor. Progress in Molecular and Environmental Bioengineering – From Analysis and Modeling to Technology Applications. Rijeka (Croatia): InTech; 2011. p. 117–62.
8. Choi JR, Yong KW, Choi JY, Cowie AC. Recent advances in photo-crosslinkable hydrogels for biomedical applications. BioTechniques. 2019;66(1):40–53.
9. Nikolić LB, Zdravković AS, Nikolić VD, Ilić-Stojanović SS. Synthetic hydrogels and their impact on health and environment. In: Mondal MIH, editor. Cellulose-Based Superabsorbent Hydrogels. Cham (Switzerland): Springer; 2018. p. 1–22.
10. Summonte S, Racaniello GF, Lopedota A, Denora N, Bernkop-Schnürch A. Thiolated polymeric hydrogels for biomedical application: cross-linking mechanisms. J Control Release. 2021;330:470–82.
11. Jeong B, Kim SW, Bae YH. Thermosensitive sol–gel reversible hydrogels. Adv Drug Deliv Rev. 2002;54(1):37–51.
12. Kharkar PM, Kiick KL, Kloxin AM. Designing degradable hydrogels for orthogonal control of cell microenvironments. Chem Soc Rev. 2013;42(3):733–55.
13. Karchoubi F, Ghotli RA, Pahlevani H, Salehi MB. New insights into nanocomposite hydrogels; a review on recent advances in characteristics and applications. Adv Ind Eng Polym Res. 2024;7:54–78.
14. Hoare TR, Kohane DS. Hydrogels in drug delivery: progress and challenges. Polymer (Guildf). 2008;49(8):1993–2007.
15. Athanassiadis AG, Ma MZ, Moreno-Gomez N, Melde K, Choi E, Goyal R, et al. Ultrasound-responsive systems as components for smart materials. Chem Rev. 2022;122(5):5165–208.
16. Kharkar PM, Kiick KL, Kloxin AM. Designing degradable hydrogels for orthogonal control of cell microenvironments. Chem Soc Rev. 2013;42(3):733–55.
17. Luo Z, Wang M, Wang H, Han Y, Shen Y, Yuan W, et al. Injectable porous microchips with oxygen reservoirs and an immune-niche enhance the efficacy of CAR T cell therapy in solid tumors. ACS Appl Mater Interfaces. 2021;13(3):4781–96.
18. Annabi N, Zhang YN, Assmann A, Sani ES, Cheng G, Lassaletta AD, et al. Engineering a highly elastic human protein–based sealant for surgical applications. Sci Transl Med. 2017;9(410):eaai7466.
19. Smith TT, Stephan SB, Moffett HF, McKnight LE, Ji W, Reiman D, et al. Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors. J Clin Invest. 2017;127(6):2176–91.
20. Grosskopf AK, Roth GA, Smith AA, Gale EC, Hernandez HL, Hubka KM, et al. Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors. Sci Adv. 2022;8(14):eabn8264.
21. Gounden V, Singh M. Hydrogels and wound healing: current and future prospects. Gels. 2024;10(1):43.
22. Drury JL, Mooney DJ. Hydrogels for tissue engineering: scaffold design variables and applications. Biomaterials. 2003;24(24):4337–51.
23. Sulley A, Dumbleton K. Silicone hydrogel daily disposable benefits: the evidence. Cont Lens Anterior Eye. 2020;43(4):298–307.
24. Patra SK, Majumdar R, Acharya A, Paul PK, Basu S. Prospects of hydrogels in agriculture for enhancing crop and water productivity under water deficit condition. Int J Polym Sci. 2022;2022:4914836.
25. Tavakoli J, Tang Y. Hydrogel based sensors for biomedical applications: an updated review. Polymers. 2017;9(8):364.
26. Soto-Bustamante F, Bassu G, Fratini E, Laurati M. Effect of composition and freeze-thaw on the network structure, porosity and mechanical properties of polyvinyl-alcohol/chitosan hydrogels. Gels. 2023;9(5):396.
27. Rahmanian-Devin P, Rahimi VB, Askari VR. Thermosensitive chitosan-β-glycerophosphate hydrogels as targeted drug delivery systems: an overview on preparation and their applications. Adv Pharmacol Pharm Sci. 2021;2021:6640893.
28. Di J, Price J, Gu Z, Zhao X. Stretch-triggered drug delivery from wearable elastomer films containing therapeutic depots. ACS Nano. 2015;9(9):9407–15.
29. Crompton KE, Goud JD, Bellamkonda RV, Gengenbach TR, Finkelstein DI, Horne MK, et al. Polylysine-functionalised thermoresponsive chitosan hydrogel for neural tissue engineering. Biomaterials. 2007;28(3):441–9.
30. Shukla SK, Mishra AK, Arotiba OA, Mamba BB. Chitosan-based nanomaterials: a state-of-the-art review. Int J Biol Macromol. 2013;59:46–58.
31. Mamidi N, De Silva FF, Vacas AB, Gómez JAG, Goo NYM, Mendoza DR, et al. Multifaceted hydrogel scaffolds: Bridging the gap between biomedical needs and environmental sustainability. Adv Healthc Mater. 2024;13(14):2401195.

Trends in Drug Delivery
| Volume | 12 |
| Issue | 03 |
| Received | 24/05/2025 |
| Accepted | 25/06/2025 |
| Published | 23/08/2025 |
| Publication Time | 91 Days |
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