Microneedles: A Modern Breakthrough in Drug Delivery Systems

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nThis is an unedited manuscript accepted for publication and provided as an Article in Press for early access at the author’s request. The article will undergo copyediting, typesetting, and galley proof review before final publication. Please be aware that errors may be identified during production that could affect the content. All legal disclaimers of the journal apply.n

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Year : 2025 [if 2224 equals=””]12/10/2025 at 1:56 PM[/if 2224] | [if 1553 equals=””] Volume : 12 [else] Volume : 12[/if 1553] | [if 424 equals=”Regular Issue”]Issue : [/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] 03 | Page :

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    Ujjawal Tamboli, Pankaj Chasta, Chhaya Deval, Shivam Rongpi, Kamalesh Mistry,

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  1. Research Scholar, Associate Professor, Manufacturing Chemist, Assistant Professor, Assistant Professor, Department of Pharmacy, Faculty of Pharmaceutical Science, Mewar University, Gangrar, Chittorgarh, Department of Pharmacy, Faculty of Pharmaceutical Science, Mewar University, Gangrar, Chittorgarh, Malook Pharmaceutical Pvt. Ltd., Department of Pharmacy, Faculty of Pharmaceutical Science, Mewar University, Gangrar, Chittorgarh, Department of Pharmacy, Faculty of Pharmaceutical Science, Mewar University, Gangrar, Chittorgarh, Rajasthan, Rajasthan, South Delhi, Rajasthan, Rajasthan, India, India, India, India, India

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nMicroneedles (MNs) represent a revolutionary and transformative advancement in the realm of transdermal drug delivery systems, which are designed to facilitate the administration of therapeutic agents through the skin. These exceptionally small, micron-scale needles penetrate the stratum corneum, thereby enabling the direct delivery of pharmacological agents into the underlying dermis or the upper epidermis, consequently enhancing bioavailability while simultaneously circumventing the detrimental effects of first-pass metabolism and the degradation that often occurs within the digestive system. Fabricated from a variety of materials including, but not limited to, metals, polymers, silicon, and various sugars, microneedles are produced through cutting-edge manufacturing processes such as photolithography, micromolding, and advanced 3D printing techniques, and they can be classified into several categories including solid, coated, dissolving, hollow, and hydrogel-forming. They have exhibited remarkable potential across a wide array of applications, including cosmetic enhancements, diagnostic purposes, oncological treatments, vaccination strategies, and innovative drug delivery systems. Despite the numerous advantages that microneedles offer, such as enhanced patient compliance and the convenience of self-administration, there remain significant challenges that must be addressed, including issues related to mechanical strength, inadequate drug loading capabilities, and various regulatory hurdles that could impede their widespread adoption. The ongoing research focused on the development of intelligent microneedles and personalized therapeutic approaches underscores the pivotal role that microneedles are poised to play as an essential innovation in the future landscape of healthcare solutions.nn

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Keywords: Microneedles, Transdermal Drug Delivery, Minimally Invasive Systems, Controlled Release Technology, Pharmaceutical Microfabrication.

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[/if 424][if 424 equals=”Special Issue”][This article belongs to Special Issue under section in Trends in Drug Delivery (tdd)][/if 424][if 424 equals=”Conference”]This article belongs to Conference [/if 424]

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How to cite this article:
nUjjawal Tamboli, Pankaj Chasta, Chhaya Deval, Shivam Rongpi, Kamalesh Mistry. [if 2584 equals=”][226 wpautop=0 striphtml=1][else]Microneedles: A Modern Breakthrough in Drug Delivery Systems[/if 2584]. Trends in Drug Delivery. 11/10/2025; 12(03):-.

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nUjjawal Tamboli, Pankaj Chasta, Chhaya Deval, Shivam Rongpi, Kamalesh Mistry. [if 2584 equals=”][226 striphtml=1][else]Microneedles: A Modern Breakthrough in Drug Delivery Systems[/if 2584]. Trends in Drug Delivery. 11/10/2025; 12(03):-. Available from: https://journals.stmjournals.com/tdd/article=11/10/2025/view=0

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Volume 12
[if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] 03
Received 16/06/2025
Accepted 21/06/2025
Published 11/10/2025
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Publication Time 117 Days

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