Formulation and Evaluation of Transdermal Patch to Enhance Treatment of Alopecia

Year : 2025 | Volume : 12 | Issue : 02 | Page : 20 33
    By

    Jagtap Umakant Sanjay,

  • More Krutika Arvind,

  • Jain Aachal Vinod,

  • Sulbha Gopal Patil,

  1. Student, B. Pharm, Department of Pharmaceutics, P. S. G. V. P, Mandal’s College of Pharmacy, Shahada, Maharashtra, India
  2. Student, B. Pharm, Department of Pharmaceutics, P. S. G. V. P, Mandal’s College of Pharmacy, Shahada, Maharashtra, India
  3. Student, B. Pharm, Department of Pharmaceutics, P. S. G. V. P, Mandal’s College of Pharmacy, Shahada, Maharashtra, India
  4. Associate Professor, Department of Pharmaceutical Chemistry, P. S. G. V. P, Mandal’s College of Pharmacy, Shahada, Maharashtra, India

Abstract

The improvement of novel topical sedate conveyance frameworks has picked up noteworthy consideration due to their potential in upgrading the helpful viability and persistent compliance whereas minimizing systemic side impacts. This thinks about centers on the definition and assessment of transdermal patches planned to discharge allicin, the essential naturally dynamic compound determined from garlic (Allium sativum) extricate. Allicin is eminent for its wide range of pharmacological properties, counting antimicrobial, anti-inflammatory, antioxidant, and wound mending exercises, making it a promising candidate for dermal applications. In any case, allicin is known for its chemical flimsiness and instability, which posture critical challenges for its joining into steady details. The physicochemical characteristics of the patches were assessed, counting thickness, pliable quality, collapsing continuance, dampness substance, sedate substance consistency, and pH compatibility. In vitro medicate discharge ponders were conducted utilizing Franz dissemination cells with manufactured and porcine skin layers to recreate human skin conditions. The optimized definitions illustrated supported discharge of allicin over 24 hours with negligible corruption, keeping up organic action all through the testing period. Microbiological tests affirmed the antimicrobial adequacy of the allicin-loaded patches against both Gram-positive and Gram-negative microscopic organisms, counting Staphylococcus aureus and Escherichia coli. Furthermore, preparatory in vivo considers on creature models demonstrated eminent enhancements in wound recuperating highlights the potential of garlic-derived allicin topical patches as a characteristic, successful, and non-invasive elective for treating skin contaminations, wounds, and fiery conditions. The effective stabilization and controlled discharge of allicin in a transdermal fix arrange gives a promising establishment for assist improvement into clinically practical home-grown therapeutics. Future considerations will center on long-term solidness, large-scale generation, and clinical trials to survey security, adequacy, and persistent acknowledgment.

Keywords: Allicin, garlic extract, transdermal patches, topical drug delivery, herbal therapeutics, and irritation diminishment compared to control bunches

[This article belongs to Trends in Drug Delivery ]

How to cite this article:
Jagtap Umakant Sanjay, More Krutika Arvind, Jain Aachal Vinod, Sulbha Gopal Patil. Formulation and Evaluation of Transdermal Patch to Enhance Treatment of Alopecia. Trends in Drug Delivery. 2025; 12(02):20-33.
How to cite this URL:
Jagtap Umakant Sanjay, More Krutika Arvind, Jain Aachal Vinod, Sulbha Gopal Patil. Formulation and Evaluation of Transdermal Patch to Enhance Treatment of Alopecia. Trends in Drug Delivery. 2025; 12(02):20-33. Available from: https://journals.stmjournals.com/tdd/article=2025/view=216472


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Regular Issue Subscription Review Article
Volume 12
Issue 02
Received 14/05/2025
Accepted 03/06/2025
Published 09/07/2025
Publication Time 56 Days
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