Advances in Nanoformulations for Targeted Drug Delivery Systems

Year : 2025 | Volume : 12 | Issue : 02 | Page : 01 07
    By

    S.P.Shanmuagpriya,

  • M. Esakkiammal,

  • Yogesh Somnath Shelar,

  • Pradip Somnath Shelar,

  1. Assistant Professor, Department of Chemical Engineering, Mohamed sathak Engineering College, Ramanathapuram, Tamil Nadu, India
  2. Assistant Professor, Department of Chemistry, National College, Tiruchirappalli, Tamil Nadu, India
  3. Assistant Professor, Department of Chemistry, S.I.C.S Degree College of Arts, Science and Commerce College, Ambernath-Badlapur Road, Ambernath (West), Maharashtra, India
  4. Assistant Professor, Department of Chemistry, K. J. Somaiya College of Arts, Commerce and Science, Mohinirajnagar, Kopargaon, Maharashtra, India

Abstract

The work examines modern nanoformulations used for enhancing targeted drug delivery systems that simultaneously produce better therapeutic effects with reduced adverse effects. The pharmaceutical industry achieved deliverable drug development progress through diverse nanocarrier innovation which encompasses liposomes and nanoparticles and dendrimers and micelles. Tissue and cell-based directed delivery becomes possible via this technology to enhance the management of neurological disorders and cancer diseases. The investigation analyzes different nanoformulations by reviewing their functions and clinical adaptation patterns and hurdles and potential technologies for TDDS.

Keywords: Targeted Drug Delivery, Nanoparticles, Liposomes, Cancer Treatment and Controlled Release with Therapeutic Efficacy feature in this analysis.

[This article belongs to Trends in Drug Delivery ]

How to cite this article:
S.P.Shanmuagpriya, M. Esakkiammal, Yogesh Somnath Shelar, Pradip Somnath Shelar. Advances in Nanoformulations for Targeted Drug Delivery Systems. Trends in Drug Delivery. 2025; 12(02):01-07.
How to cite this URL:
S.P.Shanmuagpriya, M. Esakkiammal, Yogesh Somnath Shelar, Pradip Somnath Shelar. Advances in Nanoformulations for Targeted Drug Delivery Systems. Trends in Drug Delivery. 2025; 12(02):01-07. Available from: https://journals.stmjournals.com/tdd/article=2025/view=215675


References

  1. Wang, L., Zhang, Y., & Li, S. (2020). Micellar nanocarriers for drug delivery and targeting. International Journal of Pharmaceutics, 590, 119942. https://doi.org/10.1016/j.ijpharm.2020.119942
  2. Nguyen, M., & Patel, R. (2018). Liposomes and their application in drug delivery. Drug Delivery and Translational Research, 8(1), 26-35. https://doi.org/10.1007/s13346-017-0532-3
  3. Davis, M. E., Chen, Z. G., & Shin, D. M. (2020). Nanoparticle therapeutics: An emerging treatment modality for cancer. Nature Reviews Drug Discovery, 9(11), 1033-1047. https://doi.org/10.1038/nrd3241
  4. Zhang, L., Li, W., & Zhao, P. (2021). Nanoformulations in drug delivery: Mechanisms and applications in cancer. Cancer Nanotechnology, 16(4), 397-413. https://doi.org/10.1080/17518253.2021.1867385 
  1. Tan, L., Zhang, X., & Wu, Y. (2020). Surface-modified nanocarriers for targeted drug delivery. Journal of Controlled Release, 318, 61-73. https://doi.org/10.1016/j.jconrel.2020.03.014
  1. Muller, R. H., Rainer, S., & Will, M. (2019). Liposomal formulations: An advanced approach to cancer chemotherapy. International Journal of Pharmaceutics, 564, 1-10. https://doi.org/10.1016/j.ijpharm.2019.04.032
  1. Brown, J., & Zhao, Q. (2020). Dendrimers in drug delivery systems: Mechanisms and clinical applications. Journal of Nanobiotechnology, 18(1), 102-110. https://doi.org/10.1186/s12951-020-00689-0
  2. Chen, X., & Patel, K. (2020). Nanomedicine and regulatory challenges in drug delivery: A review. Frontiers in Pharmacology, 11, 984-997. https://doi.org/10.3389/fphar.2020.00984
  3. Smith, J., Liu, W., & Zhao, Z. (2019). Nanoformulations and their therapeutic potentials in drug delivery systems. Journal of Nanoscience and Nanotechnology, 19(7), 3827-3835. https://doi.org/10.1166/jnn.2019.1681
  1. Zhao, Y., & Guo, X. (2021). Targeted drug delivery systems and their advancements in cancer therapy. Journal of Controlled Release, 329, 253-267. https://doi.org/10.1016/j.jconrel.2020.10.030
  1. Johnson LR, Lee DY, Eacret JS, Ye D, June CH, Minn AJ. The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function. Cell. 2021 Sep 16;184(19):4981-95.
  1. Patel, K., & Gupta, S. (2021). Dendrimers as a versatile tool for cancer drug delivery: Mechanisms and advancements. Materials Science and Engineering: C, 112, 110908. https://doi.org/10.1016/j.msec.2020.110908
  1. Beikang Tang, Xiaoyan Xie, Juan Lu, Wuxinrui Huang, Jietun Yang, Jing Tian, Lanjie Lei. (2024). Designing biomaterials for the treatment of autoimmune diseases. Applied Materials Today, 39, 102278. https://doi.org/10.1016/j.apmt.2024.102278
  2. Chen, Z., Li, Y., & Yang, G. (2019). The role of nanotechnology in cancer drug delivery systems. Journal of Cancer Research and Clinical Oncology, 145(2), 439-450. https://doi.org/10.1007/s00432-019-02947-5
  3. Balasubramanian, R., Khadse, S., Kaleeswaran, D., Thangavelu, A. U., & Kumari, M. (2024). Advances in CRISPR and Genetic Engineering Ethical Considerations. Biochemical & Cellular Archives.
  1. Gao, J., Wang, L., & Zhang, X. (2020). Stimuli-responsive drug delivery systems for targeted cancer therapy. Journal of Controlled Release, 320, 13-27. https://doi.org/10.1016/j.jconrel.2020.01.024
  2. Liu, Y., & Li, X. (2020). Micelles and their applications in drug delivery systems: An overview. Nanomedicine, 15(3), 269-286. https://doi.org/10.2217/nnm-2020-0292
  3. Liu, Z., & Patel, S. (2020). Scalable production of nanocarriers for drug delivery: Challenges and advancements. Journal of Pharmaceutical Sciences, 109(1), 63-74. https://doi.org/10.1016/j.xphs.2019.10.016
  4. Liu, Z., Li, X., & Zhang, H. (2019). Nanocarriers for drug delivery in cancer treatment: A review. Journal of Drug Targeting, 27(9), 1133-1145. https://doi.org/10.1080/1061186X.2019.1657899
  5. Mao, S., Zhang, Y., & Xu, J. (2020). Toxicological profiles of nanomaterials in drug delivery applications. Nanotoxicology, 14(3), 153-165. https://doi.org/10.1080/17435390.2020.1724191
  6. Ramanathan, R., & Zhang, L. (2018). Micellar formulations and their applications in cancer treatment. Nanomedicine, 13(4), 515-531. https://doi.org/10.2217/nnm-2018-0010
  7. Wang, Y., Li, Q., & Zhang, Z. (2021). Solid lipid nanoparticles for oral drug delivery systems: Challenges and opportunities. Drug Development and Industrial Pharmacy, 47(2), 168-175. https://doi.org/10.1080/03639045.2020.1869251
  8. Zhao, L., & Zhang, Q. (2019). Blood-brain barrier penetration and drug delivery using nanocarriers: New advancements. Journal of Drug Delivery Science and Technology, 55, 101484. https://doi.org/10.1016/j.jddst.2019.101484
  9. Arshan, M. M. K., Jurla, A., & Khadse, S. (2020). Isolation and Identification of Bacteria from Wound Infection and Their Antibiogram, vol. 5, issue 4. https://doi.org/10.30780/IJTRS.V05.I04.004 
Regular Issue Subscription Review Article
Volume 12
Issue 02
Received 16/04/2025
Accepted 27/05/2025
Published 02/07/2025
Publication Time 77 Days
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