Review on Sustained Released Matrix Tablet

Year : 2025 | Volume : 12 | Issue : 02 | Page : 60 69
    By

    Pranjal Girish Khedkar,

  • Rohit Suresh Marathe,

  • Himanshu Dilip Jain,

  • Yogesh B. Rokde,

  • Hitendra S. Chaudhari,

  • S.P Pawar,

  1. Student, Department of Pharmaceuties, P. S. G. V. P. Mandal’s College of Pharmacy, shahada, Maharashtra, India
  2. Student, Department of Pharmaceuties, P. S. G. V. P. Mandal’s College of Pharmacy, shahada, Maharashtra, India
  3. Student, Department of Pharmaceuties, P. S. G. V. P. Mandal’s College of Pharmacy, shahada, Maharashtra, India
  4. Associate Professor, Department of Pharmaceutical Chemistry, P. S. G. V. P. Mandal’s College of Pharmacy, shahada, Maharashtra, India
  5. Associate Professor, Department of Pharmaceutical Chemistry, P. S. G. V. P. Mandal’s College of Pharmacy, shahada, Maharashtra, India
  6. Principal, Department of Pharmacy, P. S. G. V. P. Mandal’s College of Pharmacy, shahada, Maharashtra, India

Abstract

Pharmaceuticals often use sustained release dose forms to prolong the therapeutic agent’s presence in the bloodstream and maintain a consistent plasma profile. The matrix governs the drug’s release rate. Hydroxypropyl methyl cellulose, a release retardant, is a key excipient in formulations due to its ability to promote sustained release. Techniques that include wet granulation, direct compression, or the dispersion of solid particles within a porous matrix, integrating polymers, like polymethyl methacrylate, polyglycolic acid, and hydroxypropyl methyl cellulose, are utilized to generate sustained release matrix tablets. The procedure involves compressing a blend of medicine, retardant material, and additives to create a tablet with the drug contained in the retardant matrix core. The drug reservoir in a matrix diffusion-controlled system is generated by evenly dispersing particles throughout a hydrophilic or lipophilic polymer matrix. Matrix devices offer benefits, such as enhanced patient compliance, fewer fluctuations in steady-state medication levels, optimal drug utilization, and increased safety margins for powerful drugs. The matrix tablet continuously releases the medication by controlled diffusion and dissolution. Hydrophilic polymers with strong gelling capability are much sought after for matrix tablet applications.

Keywords: Ssustained released, Matrix tablet, Drug Delivery Systems, Hypothetical plasma drug concentration.

[This article belongs to Trends in Drug Delivery ]

How to cite this article:
Pranjal Girish Khedkar, Rohit Suresh Marathe, Himanshu Dilip Jain, Yogesh B. Rokde, Hitendra S. Chaudhari, S.P Pawar. Review on Sustained Released Matrix Tablet. Trends in Drug Delivery. 2025; 12(02):60-69.
How to cite this URL:
Pranjal Girish Khedkar, Rohit Suresh Marathe, Himanshu Dilip Jain, Yogesh B. Rokde, Hitendra S. Chaudhari, S.P Pawar. Review on Sustained Released Matrix Tablet. Trends in Drug Delivery. 2025; 12(02):60-69. Available from: https://journals.stmjournals.com/tdd/article=2025/view=208902


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Regular Issue Subscription Review Article
Volume 12
Issue 02
Received 28/01/2025
Accepted 01/04/2025
Published 26/04/2025
Publication Time 88 Days
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