Morphine: A Pharmacological Perspective on Its Cancer Pain Management

Year : 2025 | Volume : 12 | Issue : 01 | Page : 1 8
    By

    Mohd. Wasiullah,

  • Piyush Yadav,

  • Anjali Maurya,

  • Shikha Yadav,

  1. Principal, Department of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India
  2. Professor & Head, Department of Pharmaceutical Chemistry, Prasad Institute of Technology, Uttar Pradesh, India
  3. Assistant Professor, Department of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India
  4. Scholar, Department of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India

Abstract

Morphine continues to be a key treatment in managing cancer pain because of its strong pain-relieving effects and established clinical history. Despite the emergence of alternative opioids and pain management therapies, morphine continues to be widely prescribed, particularly in palliative care settings. However, its use has been accompanied by concerns regarding tolerance, dependence, and adverse effects, which complicate long-term administration. This review explores the pharmacological aspects of morphine in cancer pain management, including its pharmacokinetics, mechanism of action, and the challenges it poses for patients. Special attention is given to pediatrics, geriatrics, and patients with renal or liver impairment. The article also discusses emerging therapeutic strategies, such as transdermal delivery systems, multimodal analgesia, and personalized medicine approaches, to improve pain control while minimizing side effects. Future research avenues and potential innovations in opioid therapies, including kappa and delta receptor agonists, provide promising directions to address the global challenge of cancer pain relief.

Keywords: Cancer pain management, morphine, opioid analgesics, opioid delivery, papaver somniferum

[This article belongs to Trends in Drug Delivery ]

How to cite this article:
Mohd. Wasiullah, Piyush Yadav, Anjali Maurya, Shikha Yadav. Morphine: A Pharmacological Perspective on Its Cancer Pain Management. Trends in Drug Delivery. 2025; 12(01):1-8.
How to cite this URL:
Mohd. Wasiullah, Piyush Yadav, Anjali Maurya, Shikha Yadav. Morphine: A Pharmacological Perspective on Its Cancer Pain Management. Trends in Drug Delivery. 2025; 12(01):1-8. Available from: https://journals.stmjournals.com/tdd/article=2025/view=195322


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Regular Issue Subscription Review Article
Volume 12
Issue 01
Received 14/12/2024
Accepted 01/01/2025
Published 24/01/2025
Publication Time 41 Days
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