Neuroprotective Effects of Curcuma longa: A Review of Its Role in Neurodegenerative Diseases

Year : 2025 | Volume : 12 | Issue : 03 | Page : 24 32
    By

    Archana Kumari,

  • Priya Sharma,

  1. Assistant Professor, Department of Pharmacy, School of Pharmacy and Emerging Sciences, Baddi University of Emerging Sciences & Technology, Baddi, Solan, Himachal Pradesh, India
  2. Assistant Professor, Department of Pharmacy, School of Pharmacy and Emerging Sciences, Baddi University of Emerging Sciences & Technology, Baddi, Solan, Himachal Pradesh, India

Abstract

Curcuma longa (turmeric), a perennial herb notably utilized in traditional medication, has garnered big clinical attention due to its major bioactive compound, curcumin. Curcumin, well-known shows a couple of organic activities, together with antioxidant, anti-amyloidogenic, and neurodegenerative effects, making it a promising candidate for the management of neurodegenerative diseases (NDDs), which include Alzheimer’s illness, Parkinson’s disorder (PD), Huntington’s sickness (HD), and amyotrophic lateral sclerosis (ALS). This evaluate consolidates current findings at the neuroprotective mechanisms of curcumin, its pharmacokinetics, bioavailability demanding situations, and its utility in medical settings. Emphasis is laid on in vitro and in vivo studies, as well as scientific trials assisting the efficacy of curcumin in mitigating neurodegenerative pathologies. Advances in nano formulation techniques aimed at enhancing its mind-targeted shipping are also mentioned. Universal, curcumin emerges as a multifaceted neuroprotective agent with translational relevance within the prevention and treatment of NDDs.

Keywords: Curcuma longa, curcumin, neuroprotection, neurodegenerative diseases, Alzheimer’s disease, Parkinson’s disease.

[This article belongs to Research & Reviews: A Journal of Pharmacognosy ]

How to cite this article:
Archana Kumari, Priya Sharma. Neuroprotective Effects of Curcuma longa: A Review of Its Role in Neurodegenerative Diseases. Research & Reviews: A Journal of Pharmacognosy. 2025; 12(03):24-32.
How to cite this URL:
Archana Kumari, Priya Sharma. Neuroprotective Effects of Curcuma longa: A Review of Its Role in Neurodegenerative Diseases. Research & Reviews: A Journal of Pharmacognosy. 2025; 12(03):24-32. Available from: https://journals.stmjournals.com/rrjopc/article=2025/view=228676


References

  1. Gupta A, Sharma B. Neurodegenerative diseases (ND): An introduction. In: Synaptic Plasticity in Neurodegenerative Disorders. CRC Press; 2025. pp. 3–20.
  2. Kaliyadasa E, Samarasinghe BA. A review on golden species of Zingiberaceae family around the world: Genus Curcuma. Afr J Agric Res. 2019;14(9):519–531. doi: 10.5897/AJAR2018.13755.
  3. Vo TS, Vo TT, Vo TT, Lai TN. Turmeric (Curcuma longa): Chemical components and their effective clinical applications. J Turk Chem Soc A Chem. 2021;8(3):883–898. doi: 10.18596/jotcsa.913136.
  4. Chanda S, Ramachandra TV. Phytochemical and pharmacological importance of turmeric (Curcuma longa): A review. Res Rev J Pharmacol. 2019;9(1):16–23.
  5. Fuloria S, Mehta J, Chandel A, Sekar M, Rani NN, Begum MY, et al. A comprehensive review on the therapeutic potential of Curcuma longa Linn. in relation to its major active constituent curcumin. Front Pharmacol. 2022;13:820806. doi: 10.3389/fphar.2022.820806.
  6. Helson L. Curcumin (diferuloylmethane) delivery methods: A review. Biofactors. 2013;39(1):21–26. doi: 10.1002/biof.1080.
  7. Jayaprakasha GK, Rao LJ, Sakariah KK. Antioxidant activities of curcumin, demethoxycurcumin and bisdemethoxycurcumin. J Agric Food Chem. 2002;50(13):3668–3672. doi: 10.1021/jf025506a.
  8. Orellana-Paucar AM. Turmeric essential oil constituents as potential drug candidates: A comprehensive overview of their individual bioactivities. Molecules. 2024;29(17):4210. doi: 10.3390/molecules29174210.
  9. Hooda P, Malik R, Bhatia S, Al-Harrasi A, Najmi A, Zoghebi K, et al. Phytoimmunomodulators: A review of natural modulators for complex immune system. Heliyon. 2024;10(1):e23790. doi: 10.1016/j.heliyon.2023.e23790.
  10. Nebrisi EE. Neuroprotective activities of curcumin in Parkinson’s disease: A review of the literature. Int J Mol Sci. 2021;22(20):11248. doi: 10.3390/ijms222011248.
  11. Islam MT. Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders. Neurol Res. 2017;39(1):73–82. doi: 10.1080/01616412.2016.1251711.
  12. Rauf A, Badoni H, Abu-Izneid T, Olatunde A, Rahman MM, Painuli S, et al. Neuroinflammatory markers: Key indicators in the pathology of neurodegenerative diseases. Molecules. 2022;27(10):3194. doi: 10.3390/molecules27103194.
  13. Candelise N, Scaricamazza S, Salvatori I, Ferri A, Valle C, Manganelli V, et al. Protein aggregation landscape in neurodegenerative diseases: Clinical relevance and future applications. Int J Mol Sci. 2021;22(11):6016. doi: 10.3390/ijms22116016.
  14. Bhat AH, Dar KB, Anees S, Zargar MA, Masood A, Sofi MA, et al. Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight. Biomed Pharmacother. 2015;74:101–110. doi: 10.1016/j.biopha.2015.07.025.
  15. Namgyal D, Ali S, Mehta R, Sarwat M. The neuroprotective effect of curcumin against Cd-induced neurotoxicity and hippocampal neurogenesis promotion through CREB-BDNF signaling pathway. Toxicology. 2020;442:152542. doi: 10.1016/j.tox.2020.152542.
  16. Bagheri H, Ghasemi F, Barreto GE, Rafiee R, Sathyapalan T, Sahebkar A. Effects of curcumin on mitochondria in neurodegenerative diseases. Biofactors. 2020;46(1):5–20.  doi: 10.1002/biof.1566.
  17. Sajjad R, Arif R, Shah AA, Manzoor I, Mustafa G. Pathogenesis of Alzheimer’s disease: Role of amyloid-beta and hyperphosphorylated tau protein. Indian J Pharm Sci. 2018;80(4):581–591. doi: 10.4172/pharmaceutical-sciences.1000397.
  18. Chaudhuri KR, Schapira AH. Non-motor symptoms of Parkinson’s disease: Dopaminergic pathophysiology and treatment. Lancet Neurol. 2009;8(5):464–474. doi: 10.1016/S1474-4422(09)70068-7.
  19. Podvin S, Reardon HT, Yin K, Mosier C, Hook V. Multiple clinical features of Huntington’s disease correlate with mutant HTT gene CAG repeat lengths and neurodegeneration. J Neurol. 2019;266:551–564. doi: 10.1007/s00415-018-8940-6.
  20. Chico L, Ienco EC, Bisordi C, Lo Gerfo A, Petrozzi L, Petrucci A, et al. Amyotrophic lateral sclerosis and oxidative stress: A double-blind therapeutic trial after curcumin supplementation. CNS Neurol Disord Drug Targets. 2018;17(10):767–779. doi: 10.2174/1871527317666180720162029.
  21. Liu W, Zhai Y, Heng X, Che FY, Chen W, Sun D, et al. Oral bioavailability of curcumin: Problems and advancements. J Drug Target. 2016;24(8):694–702. doi: 10.3109/1061186X.2016.1157883.
  22. Lee SH, Kim HY, Back SY, Han HK. Piperine-mediated drug interactions and formulation strategy for piperine: Recent advances and future perspectives. Expert Opin Drug Metab Toxicol. 2018;14(1):43–57. doi: 10.1080/17425255.2018.1418854.
  23. Sharma P, Mishra R, Sharma B, Kumari A, Modgil S. Health sciences: Advancing healthcare through interdisciplinary approaches and innovation. Int J Multidiscip Appl Bus Educ Res. 2025;6(5):2309–2316. doi: 10.11594/ijmaber.06.05.17.
  24. Mishra R, Verma A, Sharma B, Sharma P. An overview of transdermal patches: Opportunities and obstacles in modern drug delivery. Asian J Res Med Pharm Sci. 2025;14(3):18–29. doi: 10.9734/ajrimps/2025/v14i3314.
  25. Sharma P, Dhiman S, Sharma B, Mishra R. Liver cirrhosis: Current insights and emerging therapies.
  26. Mishra R, Sharma MP. Drug discovery to personalized care: The role of AI in revolutionizing healthcare. In: The Impact of Artificial Intelligence in Healthcare Management. p. 27.
  27. Yadav A, Sharma S, Wani SN, Kaushal K, Sharma P. Development of oral herbal male contraceptive. Curr Asp Pharm Res Dev. 2022;8:77–88. doi: 10.9734/bpi/caprd/v8/3416E.
Regular Issue Subscription Review Article
Volume 12
Issue 03
Received 08/07/2025
Accepted 30/07/2025
Published 04/10/2025
Publication Time 88 Days
177

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