The Clinical Landscape of Wogonin: Advancing Targeted Treatments for Chronic Diseases

Year : 2025 | Volume : 12 | Issue : 01 | Page : 46-52
    By

    Varsha Ratan Gaikwad,

  • Anjali Singh,

  • Hritika Sawant,

  • Urvashi Pethe,

  • Sanjivani Rajput,

  • Ambika Nand Jha,

  1. Assistant Professor, Dept. of Pharmacognosy, Shri Pandit Baburao Chaughule College of Pharmacy, Maharashtra, India
  2. Student B.Pharm, Shri Pandit Baburao Chaughule College of Pharmacy, Maharashtra, India
  3. Student B.Pharm, Shri Pandit Baburao Chaughule College of Pharmacy, Maharashtra,
  4. Student B.Pharm, Shri Pandit Baburao Chaughule College of Pharmacy, Maharashtra, India
  5. Students, B.Pharm, Shri Pandit Baburao Chaughule College of Pharmacy, Bhiwandi, Maharashtra, India
  6. Assistant Professor, Department of Pharmacy Practice, School of Pharmacy, Maharashtra, India

Abstract

The traditional Chinese medicinal herb Scutellaria baicalensis Georgi, commonly known as Chinese skullcap or Huang-Qin, has long been used to treat a variety of conditions, including cancer, viral infections, and seizures. Its pharmacological effects are largely attributed to the high concentration of flavones, particularly wogonoside, and its aglycone derivative, wogonin. Among the bioactive compounds found in S. baicalensis, wogonin has garnered the most scientific attention due to its potent therapeutic properties. Extensive preclinical studies have demonstrated that wogonin exerts anti-tumor effects by inducing cell cycle arrest, promoting apoptosis, and inhibiting metastasis. This review provides a comprehensive analysis of published studies highlighting wogonin’s chemo-preventive potential and the underlying molecular mechanisms of its anti-cancer activity. It also examines how wogonin can work synergistically to improve the effectiveness of standard chemotherapy treatments. Further research into the chemistry and toxicological profile of wogonin is encouraged to ensure its safety and optimize its therapeutic application, positioning it as a promising candidate for cancer treatment. Scutellaria baicalensis Georgi, a member of the Labiaceae family, is a widely utilized medicinal herb in traditional Chinese medicine (TCM). This herb is rich in various components, primarily flavonoids like baicalin, baicalein, and wogonin. Recent studies have demonstrated that Scutellaria, either on its own or in combination with other herbs, exhibits cytostatic effects on multiple cancer cell lines, both in vitro and in vivo using mouse tumor models.

Keywords: Scutellaria baicalensis, wogonin, flavonoids, chemopreventive, anti-tumor.

[This article belongs to Research & Reviews: A Journal of Pharmacognosy ]

How to cite this article:
Varsha Ratan Gaikwad, Anjali Singh, Hritika Sawant, Urvashi Pethe, Sanjivani Rajput, Ambika Nand Jha. The Clinical Landscape of Wogonin: Advancing Targeted Treatments for Chronic Diseases. Research & Reviews: A Journal of Pharmacognosy. 2024; 12(01):46-52.
How to cite this URL:
Varsha Ratan Gaikwad, Anjali Singh, Hritika Sawant, Urvashi Pethe, Sanjivani Rajput, Ambika Nand Jha. The Clinical Landscape of Wogonin: Advancing Targeted Treatments for Chronic Diseases. Research & Reviews: A Journal of Pharmacognosy. 2024; 12(01):46-52. Available from: https://journals.stmjournals.com/rrjopc/article=2024/view=180501


References

  1. Park HG, Yoon SY, Choi JY, Lee GS, Choi JH, Shin CY, et al. Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis. Eur J Pharmacol 2007;574(2–3):112–119. doi:10.1016/j.ejphar.2007.07.011.
  2. Cao Z. Wogonin a review of its pharmacological and pharmacokinetic properties. Phytother Res. 2020;34(3):617–629.
  3. Sharma N, Singh AK, Sodhi SS, Zhang JJ, Mongre RK, Ghosh M, et al. Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways. Chin J Nat Med. 207;15(1):15–40. doi:10.1016/S1875-5364(17)30005-5.
  4. Liu W. Wogonin inhibits tumor growth by targeting multiple signaling pathways. Cancer Lett. 2016;380(0032):297–306.
  5. Uemura S, Matsushita H, Li W, Glassford AJ, Asagami T, Lee KH, et al. Diabetes mellitus enhances vascular matrix metalloproteinase activity: role of oxidative stress. Circulation Research. 2001;88(12):1291–1298. doi:10.1161/hh1201.092042.
  6. Rouhani M, Dalfard AH. Wogonin from scutellaria baicalensis-induced radioresistance in MCF-7 breast cancer cell line. Eurasian J Med Oncol. 2022;6(4):345–350. doi:10.14744/ejmo.2022.17217.
  7. Tronina T, Mrozowska M, Bartmańska A, Popłoński J, Sordon S, Huszcza E. Simple and rapid method for wogonin preparation and its biotransformation. Int J Mol Sci. 2021;22(16):8973. doi:10.3390/ijms22168973.
  8. Banik K, Khatoon E, Harsha C, Rana V, Parama D, Thakur KK, et al. Wogonin and its analogs for the prevention and treatment of cancer: A systematic review. Phytother Res. 2022;36(5):1854–1883. doi:10.1002/ptr.7386.
  9. Wang Q, Shi R, Dai Y, Li Y, Wang T, Ma Y, et al. Mechanism in the existent difference in form of wogonin/wogonoside between plasma and intestine/liver in rats. RSC Adv. 2018;8(7):3364–3373. doi:10.1039/C7RA08270C.
  10. Zhao T, Tang H, Xie L, Zheng Y, Ma Z, Sun Q, et al. Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology. J Pharm Pharmacol. 2019;71(9):1353–1369. doi:10.1111/jphp.13129.
  11. Liu Y, Wang H, Cai X. Optimization of the extraction of total flavonoids from Scutellaria baicalensis Georgi using the response surface methodology. J Food Sci Technol. 2015;52:2336–2343. doi:10.1007/s13197-014-1275-0.
  12. Dzięcioł M, Wala K, Wróblewska A, Janda-Milczarek K. The effect of the extraction conditions on the antioxidant activity and bioactive compounds content in ethanolic extracts of Scutellaria baicalensis root. Mol. 2024;29(17):4153. doi:10.3390/molecules29174153.
  13. Tzanova M, Atanasov V, Yaneva Z, Ivanova D, Dinev T. Selectivity of current extraction techniques for flavonoids from plant materials. Processes. 2020;8(10):1222. doi:10.3390/pr8101222.
  14. Do HT, Nguyen TH, Nghiem TD, Nguyen HT, Choi GJ, Ho CT, et al. Phytochemical constituents and extracts of the roots of Scutellaria baicalensis exhibit in vitro and in vivo control efficacy against various phytopathogenic microorganisms. South Afr J Bot. 2021;142:1–1. doi:10.1016/j.sajb.2021.05.034.
  15. Patra A, Abdullah S, Pradhan RC. Review on the extraction of bioactive compounds and characterization of fruit industry by-products. Bioresour Bioprocess. 2022;9(14). doi:10.1186/s40643-022-00498-3.
  16. Liu Y, Nie Y, Lu X, Zhang X, He H, Pan F, Zhou L, Liu X, Ji X, Zhang S. Cascade utilization of lignocellulosic biomass to high-value products. Green Chem. 2019;21(13):3499–3535. doi:10.1039/C9GC00473D.
  17. Yang MX, Liang YG, Chen HR, Huang YF, Gong HG, Zhang TY, et al. Isolation of flavonoids from wild Aquilaria sinensis leaves by an improved preparative high-speed counter-current chromatography apparatus. J Chromatogr Sci. 2018;56(1):18–24. doi:10.1093/chromsci/bmx076.
  18. Yin M, Wang J, Huang H, Huang Q, Fu Z, Lu Y. Analysis of flavonoid compounds by terahertz spectroscopy combined with chemometrics. ACS Omega. 2020;5(29):18134–1841. doi:10.1021/acsomega.0c01706.
  19. Tan CX, Schrader KK, Khan IA, Rimando AM. Activities of wogonin analogs and other flavones against Flavobacterium columnare. Chem Biodivers. 2015;12(2):259–272. doi:10.1002/cbdv.201400181.
  20. Shi LK, Zheng L, Liu RJ, Chang M, Jin QZ, Wang XG. Chemical characterization, oxidative stability, and in vitro antioxidant capacity of sesame oils extracted by supercritical and subcritical techniques and conventional methods: a comparative study using chemometrics. Eur J Lipid Sci Technol. 2018;120(2):1700326. doi:10.1002/ejlt.201700326.
  21. Li, HB, Jiang, Y, Chen, F. Li HB, Jiang Y, Chen F. Separation methods used for Scutellaria baicalensis active components. J Chromatogr B Analyt Technol Biomed Life Sci. 2004;812(1–2):277–290. doi:10.1016/j.jchromb.2004.06.045.
  22. Rawat S, Gupta G, Pathak S, Singh SK, Singh H, Mishra A, et al. Current biological and pharmacological updates on wogonin. EXCLI. 2020;19:635–40.
Regular Issue Subscription Review Article
Volume 12
Issue 01
Received 04/10/2024
Accepted 21/10/2024
Published 29/10/2024
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