[{“box”:0,”content”:”[if 992 equals=”Open Access”]
Open Access
n
[/if 992]n
n
n
n
n
- n t
n
Sudipta Roy
[/foreach]
n
n
n[if 2099 not_equal=”Yes”]n
- [foreach 286] [if 1175 not_equal=””]n t
- Assistant Professor, Bengal College of Pharmaceutical Technology, West Bengal, India
n[/if 1175][/foreach]
[/if 2099][if 2099 equals=”Yes”][/if 2099]nn
Abstract
nA phytosome is a complex created through the union of a natural compound, typically a plant extract, with a phospholipid. Phospholipids play a crucial role in cell membranes, possessing a structure comprising a hydrophilic (water-attracting) head and hydrophobic (water-repelling) tails. This distinctive structure enables phospholipids to construct lipid bilayers, fundamental elements of cell membranes. Phytosome increases the bioavailability, absorption of active chemical constituents in the extract with the help of hydrophobic tails of the phospholipid interacting with lipids in digestive system enhancing the absorption. Applications of Phytosome are in making the formulation of dietary supplements and herbal extracts, to improve the delivery of bioactive compounds, increasing the absorption of phytochemicals for easy accessibility to the body, in the realms of herbal medicine and nutritional supplements, focusing the significance of optimizing the absorption of bioactive compounds for therapeutic effects. Nevertheless, it is crucial to acknowledge that ongoing research explores the effectiveness and advantages of phytosomes, and individual responses to products containing phytosomes may vary. The primary objective is to enhance the absorption of phytochemicals, making them more easily accessible for utilization by the body. As this field progresses, phytosomes emerge as leaders in innovative strategies to enhance the effectiveness of natural compounds across diverse applications.
n
Keywords: Azadirachta indica, Aqueous Extract, Phytosome, Novel Drug Delivery System, Formulation, Evaluation, Azadirachta indica phytosome.
n[if 424 equals=”Regular Issue”][This article belongs to Research & Reviews: A Journal of Pharmacognosy(rrjopc)]
n
n
n
n
n
nn
nn[if 992 equals=”Open Access”] Full Text PDF Download[else] nvar fieldValue = “[user_role]”;nif (fieldValue == ‘indexingbodies’) {n document.write(‘Full Text PDF‘);n }nelse if (fieldValue == ‘administrator’) { document.write(‘Full Text PDF‘); }nelse if (fieldValue == ‘rrjopc’) { document.write(‘Full Text PDF‘); }n else { document.write(‘ ‘); }n [/if 992] [if 379 not_equal=””]n
Browse Figures
n
n[/if 379]n
References
n[if 1104 equals=””]n
i. Mukherjee PK, Kumar V, Mal M, et al. (2006). Comprehensive considerations on the traditional and modern phytocosmetic concepts of Indian herbs. Journal of Ethnopharmacology, 103(2), 113-122.
ii. Patel R, Mahobia NK. (2011). Phytosome: A novel drug delivery system for herbal medicine. International Journal of Research in Pharmaceutical and Biomedical Sciences, 2(3), 1142-1149.
iii. Gupta A, Singh V, Pal K, Singh V. (2016). Nanotechnology: A new approach for herbal cosmetics. Journal of Advanced Pharmaceutical Technology & Research, 7(1), 1-2.
iv. Kumar P, Shankar S, Srivastava RK. (2013). Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway. Cancer Letters, 343(2), 179-189.
v. Kohli K, Ali J, Ansari MJ, Raheman Z. (2010). Curcumin: A natural antiinflammatory agent. Indian Journal of Pharmacology, 42(4), 233-234.
vi. Kidd PM. (2009). Bioavailability and activity of phytosome complexes from botanical polyphenols: The silymarin, curcumin, green tea, and grape seed extracts. Alternative Medicine Review, 14(3), 226-246.
vii. Marzocchella L, Fantini M, Benvenuto M, et al. (2014). Dietary flavonoids: Molecular mechanisms of action as anti-inflammatory agents. Recent Patents on Inflammation & Allergy Drug Discovery, 8(1), 56-74.
viii. Kidd PM. (2009). Phospholipids – versatile excipients for boosting the bioavailability of poorly soluble drugs. Critical Reviews in Food Science and Nutrition, 49(10), 861-871.
ix. De Leo V, Lanzetta D, Cazzavacca R, Morgante G. (2019). Phytosome complex for oral administration of insulin. United States Patent US10213817B2.
x. Bombardelli E, Cristoni A, Morelli R. (1991). Phytosome complexation in the development of a new vaginal dosage form for the treatment of Candida infections. European Journal of Drug Metabolism and Pharmacokinetics, 16(2), 133-138.
xi. Kidd PM. (2009). Phytosomes: The new horizon in phytomedicine. Journal of the Science of Food and Agriculture, 89(8), 1126-1134.
xii. Belcaro G, Cesarone MR, Dugall M, et al. (2010). Efficacy and safety of Meriva, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Alternative Medicine Review, 15(4), 337-344.
xiii. Bombardelli E, Curri SB, Della Loggia R, Tubaro A, Gariboldi P. (1989). Complexes between phospholipids and standardised extracts of Vitis vinifera leaves or Vitis vinifera seeds: Phospholipid complexes of natural polyphenols for oral use. Fitoterapia, 60(1), 49-57.
xiv. Riva A, Togni S, Franceschi F, et al. (2019). Bioavailability and pharmacokinetic profile of grape pomace phenolic compounds in humans. Archives of Biochemistry and Biophysics, 661, 42-49.
xv. Gupta A, Kumar R, Pal K, Singh V. (2018). Nanostructured lipid carriers of silymarin: Systematic development, characterization and in vivo assessment. Materials Science and Engineering: C, 82, 16-25.
nn[/if 1104][if 1104 not_equal=””]n
- [foreach 1102]n t
- [if 1106 equals=””], [/if 1106][if 1106 not_equal=””],[/if 1106]
n[/foreach]
n[/if 1104]
nn
nn[if 1114 equals=”Yes”]n
n[/if 1114]
n
n
n
n
n
n
n
| Volume | |
| [if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] | |
| Received | February 27, 2024 |
| Accepted | March 26, 2024 |
| Published |
n
n
n
n
n
nn function myFunction2() {n var x = document.getElementById(“browsefigure”);n if (x.style.display === “block”) {n x.style.display = “none”;n }n else { x.style.display = “Block”; }n }n document.querySelector(“.prevBtn”).addEventListener(“click”, () => {n changeSlides(-1);n });n document.querySelector(“.nextBtn”).addEventListener(“click”, () => {n changeSlides(1);n });n var slideIndex = 1;n showSlides(slideIndex);n function changeSlides(n) {n showSlides((slideIndex += n));n }n function currentSlide(n) {n showSlides((slideIndex = n));n }n function showSlides(n) {n var i;n var slides = document.getElementsByClassName(“Slide”);n var dots = document.getElementsByClassName(“Navdot”);n if (n > slides.length) { slideIndex = 1; }n if (n (item.style.display = “none”));n Array.from(dots).forEach(n item => (item.className = item.className.replace(” selected”, “”))n );n slides[slideIndex – 1].style.display = “block”;n dots[slideIndex – 1].className += ” selected”;n }n”}]