Pharmacology in Clinical and Therapeutic Settings

Year : 2025 | Volume : 15 | Issue : 03 | Page : 51 58
    By

    V. Basil Hans,

  1. Research Professor, Srinivas University, Karnataka, India

Abstract

Polypharmacy, which refers to the practice of taking many medications at the same time, is becoming more common among elderly populations as a result of the steadily increasing prevalence of chronic conditions. The clinical and therapeutic consequences of polypharmacy are investigated in this paper, with a particular emphasis placed on drug-drug interactions, altered pharmacokinetics, and patient safety. The physiological changes that occur with advancing age have a substantial impact on the absorption, distribution, metabolism, and excretion of drugs, which in turn increases the likelihood of adverse drug reactions (ADRs) and therapeutic failure respectively. We examine the various methods that are now being utilized for the purpose of optimizing medicine, such as deprescribing protocols, clinical decision support technologies, and personalized pharmacotherapy techniques. In addition, the article covers the role that pharmacovigilance plays in the monitoring of drug safety and provides an overview of upcoming technologies, such as pharmacogenomic testing and artificial intelligence, that are aimed at enhancing the management of medicine for elderly patients. The purpose of this review is to highlight the urgent need for focused treatments to prevent medication-related harm and enhance therapeutic outcomes in aging populations. The review places an emphasis on a patient-centered, interdisciplinary approach.

Keywords: Clinical pathways, hepatic function, polypharmacy, technology-based interventions, Therapeutic Settings.

[This article belongs to Research and Reviews: A Journal of Pharmacology ]

How to cite this article:
V. Basil Hans. Pharmacology in Clinical and Therapeutic Settings. Research and Reviews: A Journal of Pharmacology. 2025; 15(03):51-58.
How to cite this URL:
V. Basil Hans. Pharmacology in Clinical and Therapeutic Settings. Research and Reviews: A Journal of Pharmacology. 2025; 15(03):51-58. Available from: https://journals.stmjournals.com/rrjop/article=2025/view=227041


References

  1. Robertson-Preidler J, Biller-Andorno N, Johnson TJ. What is appropriate care? An integrative review of emerging themes in the literature. BMC Health Serv Res. 2017 Jun 30;17(1):452. doi: 10.1186/s12913-017-2357-2. 
  2. MacKinnon K, Marcellus L, Rivers J, Gordon C, Ryan M, Butcher D. Student and educator experiences of maternal-child simulation-based learning: a systematic review of qualitative evidence protocol. JBI Database System Rev Implement Rep. 2015 Jan;13(1):14-26. doi: 10.11124/jbisrir-2015-1694. 
  3. Robertson-Preidler J, Anstey M, Biller-Andorno N, Norrish A. Approaches to appropriate care delivery from a policy perspective: A case study of Australia, England and Switzerland. Health Policy. 2017 Jul;121(7):770-777. doi: 10.1016/j.healthpol.2017.04.009.
  4. van den Bosch G, Versteeg K, Metselaar S, Koot L, Burchell G, Geerse O, Stoffels JMJ. Instruments for Value Elucidation in Older Adults in Clinical Practice-A Scoping Review. J Am Geriatr Soc. 2025 Apr;73(4):1267-1287. doi: 10.1111/jgs.19356.
  5. Englar RE. Recasting the gold standard – part I of II: delineating healthcare options across a continuum of care. J Feline Med Surg. 2023 Dec;25(12):1098612X231209855. doi: 10.1177/1098612X231209855.
  6. Sizear MMI, Nababan HY, Siddique MKB, Islam S, Paul S, Paul AK, Ahmed SM. Perceptions of appropriate treatment among the informal allopathic providers: insights from a qualitative study in two peri-urban areas in Bangladesh. BMC Health Serv Res. 2019 Jun 26;19(1):424. doi: 10.1186/s12913-019-4254-3.
  7. Ali D, Piffoux M. Methodological guide for assessing the carbon footprint of external beam radiotherapy: A single-center study with quantified mitigation strategies. Clin Transl Radiat Oncol. 2024 Mar 28;46:100768. doi: 10.1016/j.ctro.2024.100768. 
  8.  Keyworth C, Hart J, Armitage CJ, Tully MP. What maximizes the effectiveness and implementation of technology-based interventions to support healthcare professional practice? A systematic literature review. BMC Med Inform Decis Mak. 2018 Nov 7;18(1):93. doi: 10.1186/s12911-018-0661-3. PMID: 30404638; PMCID: PMC6223001.
  9. Trimarchi L, Caruso R, Magon G, Odone A, Arrigoni C. Clinical pathways and patient-related outcomes in hospital-based settings: a systematic review and meta-analysis of randomized controlled trials. Acta Biomed. 2021 Feb 9;92(1):e2021093. doi: 10.23750/abm.v92i1.10639. 
  10. Bertagnolli MM, Singh H. Treatment of Older Adults with Cancer – Addressing Gaps in Evidence. N Engl J Med. 2021 Sep 16;385(12):1062-1065. doi: 10.1056/NEJMp2106089. 
Regular Issue Subscription Review Article
Volume 15
Issue 03
Received 11/05/2025
Accepted 25/07/2025
Published 14/09/2025
Publication Time 126 Days
197

Login


My IP

PlumX Metrics