Assessing the impact of lifestyle factors on autoimmune risk and survival outcomes: A Population-based Study

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Year : 2025 | Volume : 15 | Issue : 02 | Page :
    By

    Jyoti Kapila,

  • Deepinder Pal Singh,

Abstract

This study investigated the interplay between lifestyle factors and genetic regulation in autoimmune diseases, focusing on the role of human T-cell metabolic and proliferative control through C-REL gene transcription. This study combined CRISPR-Cas9 manipulation of C-REL in human T-cells with a longitudinal cohort of 100 adults (autoimmune patients and controls), investigating metabolic and proliferation dynamics via flow cytometry and assays. It assessed lifestyle impacts through surveys and medical records, ensuring ethical compliance and informed consent. Analysis integrated genetic markers, lifestyle data, and disease outcomes using SPSS.In a comparative study involving 50 individuals with autoimmune disorders and 50 healthy controls, those with autoimmune conditions displayed higher BMIs, smoking prevalence (30% vs. 22%), and alcohol consumption (6.1 units vs. 4.9 units). Initial inflammatory markers including TNF-alpha, IL-6, IL-8, IFN-alpha, IFN-beta, and CRP were markedly elevated in autoimmune cases but showed a reduction over a three-year period. Elevated inflammatory markers correlated with increased disease susceptibility (HR 1.32-1.50), whereas regular physical exercise demonstrated a protective effect (HR 0.82) according to regression analysis.This study highlights lifestyle factors’ substantial influence on autoimmune disease risk and progression, correlating with diet, physical activity, smoking, alcohol intake, and stress levels. While advocating for comprehensive lifestyle adjustments to manage autoimmune risks, caution is warranted in attributing causation given study constraints. Future research should prioritize longitudinal, interventional studies with diverse demographics and objective measures to better grasp molecular pathways and refine targeted prevention and treatment strategies.

Keywords: Autoimmune diseases, C-REL gene transcription, CRISPR-Cas9 manipulation, Genetic regulation, Lifestyle factors, T-cell metabolism

[This article belongs to Research and Reviews : A Journal of Biotechnology ]

How to cite this article:
Jyoti Kapila, Deepinder Pal Singh. Assessing the impact of lifestyle factors on autoimmune risk and survival outcomes: A Population-based Study. Research and Reviews : A Journal of Biotechnology. 2025; 15(02):-.
How to cite this URL:
Jyoti Kapila, Deepinder Pal Singh. Assessing the impact of lifestyle factors on autoimmune risk and survival outcomes: A Population-based Study. Research and Reviews : A Journal of Biotechnology. 2025; 15(02):-. Available from: https://journals.stmjournals.com/rrjobt/article=2025/view=210043


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Regular Issue Subscription Original Research
Volume 15
Issue 02
Received 01/03/2025
Accepted 24/03/2025
Published 13/05/2025
Publication Time 73 Days
219

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