Pharmacokinetic and Pharmacodynamic Studies of Black Seed Derived Compound

Year : 2025 | Volume : 15 | Issue : 01 | Page : 36-43
    By

    Mohd. Wasiullah,

  • Piyush Yadav,

  • Pooja Yadav,

  • Neha Kumari,

  1. Principal, Department of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India
  2. Academic Head, Department of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India
  3. Assistant Professor, Department of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India
  4. Scholar, Department of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India

Abstract

Black seed (Nigella sativa) has been celebrated for centuries for its remarkable therapeutic properties. Among its bioactive compounds, thymoquinone (TQ) has gained significant attention in pharmacological research due to its diverse health benefits. This review delves into the pharmacokinetic (PK) and pharmacodynamic (PD) properties of black seed compounds, with a particular emphasis on TQ, the most extensively studied component. The PK of TQ includes the parameters of absorption, distribution, metabolism, and excretion (ADME), which determine how the compound behaves within the body. Understanding these factors is crucial to optimizing its therapeutic potential. On the pharmacodynamic front, TQ exhibits mechanisms of action, such as antioxidant, anti-inflammatory, and anticancer effects, making it a promising candidate for drug development. Additionally, clinical studies on black seed derivatives have shown encouraging results in managing various diseases, including inflammation, diabetes, cardiovascular disorders, and cancer. These findings highlight the immense potential of black seed compounds in modern medicine. By exploring the therapeutic benefits and mechanisms of action of TQ and other bioactives, this review aims to provide a comprehensive understanding of black seed’s role in promoting health and combating disease, paving the way for its integration into clinical applications

Keywords: Nigella sativa, bioavailability, anti-inflammatory, antioxidant, black seed

[This article belongs to Research and Reviews : A Journal of Biotechnology ]

How to cite this article:
Mohd. Wasiullah, Piyush Yadav, Pooja Yadav, Neha Kumari. Pharmacokinetic and Pharmacodynamic Studies of Black Seed Derived Compound. Research and Reviews : A Journal of Biotechnology. 2025; 15(01):36-43.
How to cite this URL:
Mohd. Wasiullah, Piyush Yadav, Pooja Yadav, Neha Kumari. Pharmacokinetic and Pharmacodynamic Studies of Black Seed Derived Compound. Research and Reviews : A Journal of Biotechnology. 2025; 15(01):36-43. Available from: https://journals.stmjournals.com/rrjobt/article=2025/view=196659



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Regular Issue Subscription Review Article
Volume 15
Issue 01
Received 14/12/2024
Accepted 11/01/2025
Published 01/02/2025
Publication Time 49 Days
Total Visits: 61


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