Domino Reaction for the Synthesis of Nitroolefin Heterocyclic Compound Via Thiazole Formation Followed by Claisen Rearrangement

Open Access

Year : 2022 | Volume : | Issue : 2 | Page : 18-22
By

    A.R.N. Vaishnavi

  1. Research Scholar, Department of Chemistry, Government Arts College for men, Chennai-35, Nandhanam, Tamil Nadu, India

Abstract

The Baylis-Hillman adducts derived from nitroolefins have been conveniently transformed into Claisen rearrangement. These substances, which include benzothiazole moiety, are very biologically reactive substances. This novel nitro derivative of 2-((E)-2-nitro-3-phenylallyloxy)-3-ethoxybenzaldehyde was simply treated with mole percentage of 2-(2-(2-aminophenyl) disulfanyl) benzenamine in melt reactive condition. Hence this novel 2-(benzo[d]thiazol-2-yl)-6-ethoxy-4-((E)-2-nitro-3-phenylallyl)phenol core unit compounds was very intrusting and new opportunities for the preparation of closely related to the different [3,3] sigmatropic rearrangements related to the Claisen rearrangement molecule. In situ production of a monomer succeeded from an intramolecular [4 + 2] cycloaddition reaction have been shown to be a solid-state melt reaction (SSMR) for the manufacturing of tetracyclic chromenopyran pyrimidinedione frameworks employing Baylis-Hillman derivatives. High stereoselectivity and stereospecificity were used to create the tetracyclic frameworks without the need of a catalyst or solvent. The isolated yield is very good, and the pure product can be obtained without using column chromatography for purification.

Keywords: Nitroolefins, baylis-hillman adducts, claisen rearrangement, ethoxybenzaldehyde, disulfanylbenzenamine, (phenylallyl) phenol

[This article belongs to Journal of Modern Chemistry & Chemical Technology(jomcct)]

How to cite this article: A.R.N. Vaishnavi Domino Reaction for the Synthesis of Nitroolefin Heterocyclic Compound Via Thiazole Formation Followed by Claisen Rearrangement jomcct 2022; 13:18-22
How to cite this URL: A.R.N. Vaishnavi Domino Reaction for the Synthesis of Nitroolefin Heterocyclic Compound Via Thiazole Formation Followed by Claisen Rearrangement jomcct 2022 {cited 2022 Aug 30};13:18-22. Available from: https://journals.stmjournals.com/jomcct/article=2022/view=89850

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Regular Issue Open Access Article
Volume 13
Issue 2
Received August 5, 2022
Accepted August 16, 2022
Published August 30, 2022