Flaxseed and Diabetes Management: A Comprehensive Review of Recent Studies and Potential Mechanisms

Year : 2025 | Volume : 02 | Issue : 01 | Page : 24 32
    By

    Poonam Bakhetia,

  1. Assistant Professor, Department of Food and Nutrition, College of Community Science, PAU, Ludhiana, Punjab, India

Abstract

Diabetes mellitus, a condition characterized by chronic hyperglycemia, has become a significant global health challenge, leading to substantial morbidity and mortality rates. Dietary techniques are crucial for the effective control of diabetes, including both pharmaceutical and non-pharmacological therapies. Flaxseed (Linum usitatissimum) is one of the functional foods that has attracted a lot of interest because of its abundance of bioactive components, including lignans, dietary fiber, and alpha-linolenic acid (ALA). The potential of flaxseed in managing diabetes stems from its capacity to enhance insulin sensitivity and glycemic control. It has high soluble fiber which slows down the digestive system’s absorption of glucose, thus helps in controlling blood sugar levels. Furthermore, the omega-3 fatty acid ALA has anti-inflammatory and cardioprotective properties that are especially helpful for diabetics who are more susceptible to cardiovascular disorders. Another essential flaxseed ingredient, lignans, has been related to better lipid profiles by lowering LDL cholesterol and enhancing general heart health, both of which are critical for people with diabetes. Numerous preclinical and clinical studies have demonstrated that flaxseed can help lower blood glucose, enhance insulin sensitivity, and reduce oxidative stress. Proposed mechanisms include enhanced beta-cell function, anti-inflammatory effects, and regulation of insulin secretion. Incorporating flaxseed to the diet in any form – whole, ground, or oil – can be a helpful tactic for managing diabetes. Still, more research is required to determine the best dosages and long-term effects. Clinical criteria must be improved before flaxseed can be considered a standard ingredient in diabetic dietary recommendations.

Keywords: Flaxseed, diabetes mellitus, omega-3 fatty acid, glycemic control, insulin sensitivity

[This article belongs to International Journal of Nutritions ]

How to cite this article:
Poonam Bakhetia. Flaxseed and Diabetes Management: A Comprehensive Review of Recent Studies and Potential Mechanisms. International Journal of Nutritions. 2024; 02(01):24-32.
How to cite this URL:
Poonam Bakhetia. Flaxseed and Diabetes Management: A Comprehensive Review of Recent Studies and Potential Mechanisms. International Journal of Nutritions. 2024; 02(01):24-32. Available from: https://journals.stmjournals.com/ijn/article=2024/view=179103


References

  1. Aliani M, Ryland D, Pierce GN. Effect of flax addition on the flavor profile of muffins and snack bars. Food Res Int. 2011;44:2489–2496. doi: 10.1016/j.foodres.2011.01.044.
  2. Austria JA, Aliani M, Malcolmson LJ, Dibrov E, Blackwood DP, Maddaford TG, et al. Daily food choices over one year when patient diets are supplemented with milled flaxseed. J Funct Foods. 2016;26:772–780. doi: 1016/j.jff.2016.08.045.
  3. Austria JA, Richard MN, Chahine MN, Edel AL, Malcolmson LJ, Dupasquier CMC, et al. Bioavailability of alpha-linolenic acid in subjects after ingestion of three different forms of flaxseed. J Am Coll Nutr. 2008;27(2):214–221. doi: 10.1080/07315724.2008.10719693.
  4. Bloedon LT, Balikai S, Chittams J, Cunnane SC, Berlin JA, Rader DJ, et al. Flaxseed and cardiovascular risk factors: Results from a double-blind, randomized, controlled clinical trial. J Am Coll Nutr. 2008;27(1):65–74. doi: 10.1080/07315724.2008.10719676.
  5. Coulman KD, Liu Z, Michaelides J, Quan Hum W, Thompson LU. Fatty acids and lignans in unground whole flaxseed and sesame seed are bioavailable but have minimal antioxidant and lipid-lowering effects in postmenopausal women. Mol Nutr Food Res. 2009;53(11):1366–1375. doi: 10.1002/mnfr.200900032.
  6. Czech A, Klimiuk K, Sembratowicz I. Effect of the inclusion of extruded flaxseed in the diet of fattening pigs on lipid metabolism and tissue redox status. Sci Rep. 2023;13:13312. doi: 10.1038/s41598-023-40378-0.
  7. Goyal A, Sharma V, Upadhyay N, Gill S, & Sihag M. Flax and flaxseed oil: An ancient medicine & modern functional food. J Fd Sci Tech. 2014;51(9):1633–1653. doi: 10.1007/s13197-013-1247-9.
  8. Hallund J, Tetens I, Bügel S, Tholstrup T, Bruun JM. The effect of a lignan complex isolated from flaxseed on inflammation markers in healthy postmenopausal women. Nutr Metab Cardiovasc Dis. 2008;18(7):497–502. doi: 10.1016/j.numecd.2007.05.007.
  9. Hutchins AM, Brown BD, Cunnane SC, Domitrovich SG, Adams ER, Bobowiec CE. Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: A randomized study. Nutr Res. 2013;33(5):367–375. doi: 10.1016/j.nutres.2013.02.012.
  10. Javidi A, Mozaffari-Khosravi H, Nadjarzadeh A, Dehghani A, Eftekhari MH. The effect of flaxseed powder on insulin resistance indices and blood pressure in prediabetic individuals: A randomized controlled clinical trial. J Res Med Sci. 2016;21:70. doi: 10.4103/1735-1995.189660.
  11. Joshi K, Lad S, Kale M, Patwardhan B, Mahadik SP, Patni B, et al. Supplementation with flax oil and vitamin C improves the outcome of attention deficit hyperactivity disorder (ADHD). Prostaglandins Leukot Essent Fatty Acids. 2006;74(1):17–21. doi: 10.1016/j.plefa.2005.10.001.
  12. Kajla P, Sharma A, & Sood DR. Flaxseed—a potential functional food source. J Fd Sci Tech. 2015;52(4):1857–1871. doi: 10.1007/s13197-014-1293-y.
  13. Khalesi S, Irwin C, Schubert M. Flaxseed consumption may reduce blood pressure: A systematic review and meta-analysis of controlled trials. J Nutr. 2015; 145(4):758–765. doi: 10.3945/jn.114.205302.
  14. Kristensen M, Jensen MG. Dietary fibres in the regulation of appetite and food intake: Importance of viscosity. Appetite. 2011;56(1): 65–70. doi: 10.1016/j.appet.2010.11.147.
  15. Kuijsten A, Arts IC, Vree TB, Hollman PC. Pharmacokinetics of enterolignans in healthy men and women consuming a single dose of secoisolariciresinol diglucoside. J Nutr. 2005;135(4):795–801. doi: 10.1093/jn/135.4.795.
  16. Mani UV, Mani I, Biswas M, Kumar SN. An open-label study on the effect of flax seed powder (Linum usitatissimum) supplementation in the management of diabetes mellitus. J Diet Suppl. 2011;8(3):257–265. doi: 10.3109/19390211.2011.593615.
  17. Musazadeh V, Jafarzadeh J, Keramati M, Zarezadeh M, Ahmadi M, Farrokhian Z, et al. Flaxseed oil supplementation augments antioxidant capacity and alleviates oxidative stress: A systematic review and meta-analysis of randomized controlled trials. Evid Based Complement Alternat Med. 2021;2021:4438613. doi: 10.1155/2021/4438613.
  18. Nitzke D, Czermainski J, Rosa C, Coghetto C, Fernandes SA, Carteri RB. Increasing dietary fiber intake for type 2 diabetes mellitus management: A systematic review. World J Diabetes. 2024;15(5):1001–1010. doi: 10.4239/wjd.v15.i5.1001.
  19. Özpak Akkuş Ö, Özdemir Y, Özbek Ç, Öncel B, Yapıcı Nane B. Does flaxseed and chia use affect postprandial glucose, insulin, and subjective saturation response in healthy individuals? Effect of chia and flaxseed on glycemic control and satiety. J Surg Med. 2023;7(8):434–440.
  20. Pan A, Sun J, Chen Y, Ye X, Li H, Yu Z, et al. Effects of a flaxseed-derived lignan supplement in type-2 diabetic patients: A randomized double-blind, cross-over trial. PLoS One. 2007;2(11): doi: 10.1371/journal.pone.0001148.
  21. Pan A, Yu D, Demark-Wahnefried W, Franco OH, Lin X. Meta-analysis of the effects of flaxseed interventions on blood lipids. Am J Clin Nutr. 2009;90(2):288–297. doi: 10.3945/ajcn.2009.27469.
  22. Parikh M, Netticadan T, Pierce GN. Flaxseed: its bioactive components and their cardiovascular benefits. Am J Physiol Heart Circ Physiol. 2018;314(2):H146–H159.. doi: 10.1152/ajpheart.00400.2017.
  23. Patade A, Devareddy L, Lucas EA, Korlagunta K, Daggy BP, Arjmandi BH. Flaxseed reduces total and LDL cholesterol concentrations in Native American postmenopausal women. J Womens Health (Larchmt). 2008;17(03):355–366. doi: 10.1089/jwh.2007.0359.
  24. Patenaude A, Rodriguez-Leyva D, Edel AL, Dibrov E, Dupasquier CMC, Austria JA, et al. Bioavailability of alpha-linolenic acid from flaxseed diets as a function of the age of the subject. Eur J Clin Nutr. 2009;63(9):1123–1129. doi: 10.1038/ejcn.2009.41.
  25. Pohjanheimo TA, Hakala MA, Tahvonen RL, Salminen SJ, Kallio HP. Flaxseed in breadmaking: Effects on sensory quality, aging, and composition of bakery products. J Food Sci. 2006;71(4):S34–S348. doi: 10.1111/j.1750-3841.2006.00005.x.
  26. Prasad K, Mantha SV, Muir AD, Westcott ND. Protective effect of secoisolariciresinol diglucoside against streptozotocin-induced diabetes and its mechanism. Mol Cell Biochem. 2000; 206(1-2):141–149. doi: 10.1023/a:1007018030524.
  27. Prasad K. Flaxseed and cardiovascular health. J Cardiovasc Pharmacol. 2009;54(5):369–377. doi: 10.1097/FJC.0b013e3181af04e5.
  28. Ramicharitrar A, Badrie N, Mattfeldt-Beman M, Matsuo H, Ridley C. Consumer acceptability of muffins with flaxseed (Linum usitatissimum). J Food Sci. 2005;70:s504–s507. doi: 10.1111/j.1365-2621.2005.tb11499.x.
  29. Rodriguez-Leyva D, Weighell W, Edel AL, La Vallee R, Dibrov E, Pinneker R, et al. Potent anti-hypertensive action of dietary flaxseed in hypertensive patients. 2013;62(6):1081–1089. doi: 10.1161/HYPERTENSIONAHA.113.02094.
  30. Sadat Masjedi M, Mohammadi Pour P, Shokoohinia Y, Asgary S. Effects of flaxseed on blood lipids in healthy and dyslipidemic subjects: A systematic review and meta-analysis of randomized controlled trials. Curr Probl Cardiol. 2021;47(7):100931. doi: 10.1016/j.cpcardiol.2021.100931.
  31. Schwab US, Callaway JC, Erkkilä AT, Gynther J, Uusitupa MI, Järvinen T. Effects of hempseed and flaxseed oils on the profile of serum lipids, serum total and lipoprotein lipid concentrations and haemostatic factors. Eur J Nutr. 2006;45(08):470–477. doi: 10.1007/s00394-006-0621-z.
  32. Slavin JL. Dietary fiber and body weight. 2005; 21(3):411–418.
  33. Soltanian N, Janghorbani M. Effect of flaxseed or psyllium vs. placebo on management of constipation, weight, glycemia, and lipids: A randomized trial in constipated patients with type 2 diabetes. Clin Nutr ESPEN. 2019;29:41–48. doi: 10.1016/j.clnesp.2018.11.002.
  34. Thompson LU, Chen JM, Li T, Strasser-Weippl K, Goss PE. Dietary flaxseed alters tumor biological markers in postmenopausal breast cancer. Clin Cancer Res. 2005;11(10):3828–3835. doi: 10.1158/1078-0432.CCR-04-2326.
  35. Thompson LU, Cunnane SC, eds. Flaxseed in Human Nutrition. 2nd ed. Champaign, IL: AOCS Press; 2003. pp. 2525–2531.
  36. World Health Organization (WHO). Global report on diabetes. World Health Organization. 2016. Retrieved from https://www.who.int/diabetes/global-report/en/
  37. Yang C, Xia H, Wan M, Lu Y, Xu D, Yang X, et al. Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines, and anthropometric indices in patients with dyslipidemia-related diseases: Systematic review and a dose-response meta-analysis of randomized controlled trials. Nutr Metab (Lond). 2021;18(1):91. doi: 10.1186/s12986-021-00619-3.
  38. Yao B, Fang H, Xu W, Yan Y, Xu H, Liu Y, et al. Dietary fiber intake and risk of type 2 diabetes: A dose-response analysis of prospective studies. Eur J Epidemiol. 2014;29(2):79–88. doi: 10.1007/s10654-013-9876-x.
  39. Yin S, Xu H, Xia J, Lu Y, Xu D, Sun J, et al. Effect of alpha-linolenic acid supplementation on cardiovascular disease risk profile in individuals with obesity or overweight: A systematic review and meta-analysis of randomized controlled trials. Adv Nutr. 2023;14(6):1644–1655. doi: 10.1016/j.advnut.2023.09.010.
  40. Zhang W, Wang X, Liu Y, Tian H, Flickinger B, Empie MW, et al. Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolaemic subjects. Br J Nutr. 2008;99(6):1301–1309. doi: 10.1017/S0007114507871649.
Regular Issue Subscription Review Article
Volume 02
Issue 01
Received 20/09/2024
Accepted 08/10/2024
Published 10/10/2024
Publication Time 20 Days
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