Fungal-derived Nutraceuticals & Bioactive Compounds with Physiotherapeutic and Health- promoting Properties: A Comprehensive Review

[{“box”:0,”content”:”n[if 992 equals=”Open Access”]n

n

n

n

Open Access

nn

n

n[/if 992]n[if 2704 equals=”Yes”]n

n

Notice

nThis is an unedited manuscript accepted for publication and provided as an Article in Press for early access at the author’s request. The article will undergo copyediting, typesetting, and galley proof review before final publication. Please be aware that errors may be identified during production that could affect the content. All legal disclaimers of the journal apply.n

n[/if 2704]n

n

Year : 2025 [if 2224 equals=””]07/10/2025 at 12:04 PM[/if 2224] | [if 1553 equals=””] Volume : 02 [else] Volume : 02[/if 1553] | [if 424 equals=”Regular Issue”]Issue : [/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] 02 | Page :

n

n

nn

n

n

n

    By

    n

    [foreach 286]n

    n

    Dr. Mukesh Chander,

    n t

  • n

    n[/foreach]

    n

n[if 2099 not_equal=”Yes”]n

    [foreach 286] [if 1175 not_equal=””]n t

  1. Professor (Assistant) & Dean Research (Former), Bioprocess Laboratory, P.G. Department of BioTechnology, Khalsa College (Autonomous),, Punjab, India

    2. n[/if 1175][/foreach]

n[/if 2099][if 2099 equals=”Yes”][/if 2099]n

n

Abstract

n

n

nFungal-derived nutraceuticals represent a rapidly expanding field in biomedical research, offering a rich source of bioactive compounds with diverse therapeutic applications. This comprehensive review examines the physiotherapeutic and health-promoting properties of fungal metabolites, including polysaccharides, terpenes, proteins, peptides, alkaloids, fatty acids, vitamins, and minerals. Fungi produce over 9,000 bioactive compounds from approximately 22,500 microbial metabolites, with less than 5% of the fungal kingdom explored [1] . The major bioactive constituents demonstrate significant immunomodulatory, anticancer, antioxidant, antimicrobial, anti- inflammatory, neuroprotective, and cardioprotective activities through multiple molecular mechanisms. Clinical trials have validated the therapeutic potential of medicinal mushrooms in cancer adjuvant therapy, immune enhancement, and metabolic disorders with excellent safety profiles [2] . However, challenges remain in standardization, bioavailability optimization, and understanding drug interactions. This review provides comprehensive tables of fungal bioactive compounds, their mechanisms, clinical applications, and safety considerations, highlighting the immense potential of fungal-derived nutraceuticals in modern healthcare.nn

n

n

n

Keywords: Anticancer, Anti-inflammatory, Bioactive molecules, Immunomodulation, Neuroprotective, Physiotherapeutics

n[if 424 equals=”Regular Issue”][This article belongs to International Journal of Fungi ]

n

[/if 424][if 424 equals=”Special Issue”][This article belongs to Special Issue under section in International Journal of Fungi (ijf)][/if 424][if 424 equals=”Conference”]This article belongs to Conference [/if 424]

n

n

n

How to cite this article:
nDr. Mukesh Chander. [if 2584 equals=”][226 wpautop=0 striphtml=1][else]Fungal-derived Nutraceuticals & Bioactive Compounds with Physiotherapeutic and Health- promoting Properties: A Comprehensive Review[/if 2584]. International Journal of Fungi. 07/10/2025; 02(02):-.

n

How to cite this URL:
nDr. Mukesh Chander. [if 2584 equals=”][226 striphtml=1][else]Fungal-derived Nutraceuticals & Bioactive Compounds with Physiotherapeutic and Health- promoting Properties: A Comprehensive Review[/if 2584]. International Journal of Fungi. 07/10/2025; 02(02):-. Available from: https://journals.stmjournals.com/ijf/article=07/10/2025/view=0

nn

n

n[if 992 equals=”Open Access”]Full Text PDF[/if 992]n

n

n[if 992 not_equal=”Open Access”]n

n

n[/if 992]n

nn

nnn

n[if 379 not_equal=””]nn

Browse Figures

n

n

n[foreach 379]

figures

[/foreach]n

n

n

n[/if 379]

n

n

n

n

n

References n

n[if 1104 equals=””]n

1. Ahn, W. S., Kim, D. J., Chae, G. T., Lee, J. M., Bae, S. M., Sin, J. I., Kim, Y. W., Namkoong, S. E., & Lee, I. P. (2004). Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. International Journal of Gynecologic Cancer, 14(4), 589-594.
2. Biancuzzo, R. M., Young, A., Bibuld, D., Cai, M. H., Winter, M. R., Klein, E. K., Ameri, A., Reitz, R., Salameh, W., Chen, T. C., & Holick, M. F. (2010). Fortification of orange juice with 25-hydroxyvitamin D3 or vitamin D2 is as effective as an oral supplement in 13 maintaining vitamin D status in adults. American Journal of Clinical Nutrition, 91(6), 1621- 1626.
3. Bonetto, V., Ferraresi, A., Sampò, S., & Isidoro, C. (2025). Fungal bioactive compounds as emerging therapeutic options for age-related neurodegenerative disorders. International Journal of Molecular Sciences, 26(10), 4800.
4. Chay, W. Y., Tham, C. K., Toh, H. C., Lim, H. Y., Tan, C. K., Lim, C., Wang, W. W., & Choo, S. P. (2017). Coriolus versicolor (Yunzhi) use as therapy in advanced hepatocellular carcinoma patients with poor liver function or who are unfit for standard therapy. Journal of Alternative and Complementary Medicine, 23(8), 648-657.
5. Dasgupta, A., & Acharya, K. (2019). Mushrooms: an emerging resource for therapeutic terpenoids. 3 Biotech, 9(10), 369.
6. Demain, A. L., & Sanchez, S. (2009). Microbial drug discovery: 80 years of progress. Journal of Antibiotics, 62(1), 5-16.
7. Elmastasa, M., Isildaka, O., Turkekulb, I., & Temura, N. (2007). Determination of antioxidant activity and antioxidant compounds in wild edible mushrooms. Journal of Food Composition and Analysis, 20(3-4), 337-345.
8. Fortes, R. C., Novaes, M. R., Recôva, V. L., & Melo, A. L. (2009). Immunological, hematological, and glycemia effects of dietary supplementation with Agaricus sylvaticus on patients colorectal cancer. Experimental Biology and Medicine, 234(1), 53-62.
9. Gao, Y., Zhou, S., Jiang, W., Huang, M., & Dai, X. (2003). Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients. Immunological Investigations, 32(3), 201-215.
10. Graham, C. E., Cruz, M. R., Garsin, D. A., & Lorenz, M. C. (2017). Enterococcal bacteriocin EntV inhibits hyphal morphogenesis, biofilm formation, and virulence of Candida albicans. Proceedings of the National Academy of Sciences, 114(17), 4507-4512.
11. Han, J. J., Chen, Y. F., Bao, L., Yang, X. L., Liu, D. L., Li, S. J., Zhao, F., & Liu, H. W. (2013). Anti-inflammatory and cytotoxic cyathane diterpenoids from the bird’s nest fungus Cyathus africanus. Fitoterapia, 90, 22-31.
12. Hein, M., Hensel, A., Lehmann, L., Neumann, C., Dahl, E., Schmid, K. W., Sorg, R. V., & Knabbe, C. (2015). Clinical relevance of psoriasin (S100A7) expression in ductal carcinoma in situ of the breast. British Journal of Cancer, 113(12), 1719-1728.
13. Jain, S., Dixit, V. K., Malviya, N., & Ambawatia, V. (2003). Antioxidant and immunomodulator activity of Tephrosia purpurea extract. Indian Journal of Pharmacology, 35, 384-386.
14. Jedinak, A., & Sliva, D. (2008). Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway. International Journal of Oncology, 33(6), 1307-1313. 14
15. Kaplan, J. E., Benson, C., Holmes, K. K., Brooks, J. T., Pau, A., & Masur, H. (2009). Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents. MMWR Recommendations and Reports, 58(RR-4), 1-207.
16. Kim, M. Y., Seguin, P., Ahn, J. K., Kim, J. J., Chun, S. C., Kim, E. H., Seo, S. H., Kang, E. Y., Kim, S. L., Park, Y. J., Ro, H. M., & Chung, I. M. (2008). Phenolic compound concentration and antioxidant activities of edible and medicinal mushrooms from Korea. Journal of Agricultural and Food Chemistry, 56(16), 7265-7270.
17. Laszlo, M. (2024). Five health benefits of mushrooms. Cedars-Sinai Blog. Retrieved from https://www.cedars-sinai.org/blog/five-health-benefits-of-mushrooms.html 18. Lee, I. K., Kim, Y. S., Jang, Y. W., Jung, J. Y., & Yun, B. S. (2007). New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus. Bioorganic & Medicinal Chemistry Letters, 17(24), 6678-6681.
19. Lima, E. B., Sousa, C. N., Meneses, L. N., Ximenes, N. C., Santos Júnior, M. A., Vasconcelos, G. S., Lima, N. B., Patrocínio, M. C., Macedo, D., & Vasconcelos, S. M. (2012). Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review. Brazilian Journal of Medical and Biological Research, 45(6), 492-498.
20. Maity, P., Nandi, A. K., Manna, D. K., Pattanayak, M., Sen, I. K., Bhanja, S. K., Samanta, S., Paloi, S., Acharya, K., Pahan, K., & Islam, S. S. (2014). A heteroglycan from the mycelia of Lentinus sajor-caju: structure and antioxidant properties. Carbohydrate Research, 389, 18- 25.
21. Mandal, S., Maity, K. K., Bhunia, S. K., Dey, B., Patra, S., Sikdar, S. R., & Islam, S. S. (2010). Chemical analysis of new water-soluble (1→6)-,(1→4)-α,β-glucan and water- insoluble (1→3), (1→4)-β-glucan (calocyban) from alkaline extract of an edible mushroom, Calocybe indica. Carbohydrate Research, 345(18), 2657-2663.
22. Oka, S., Tanaka, S., Yoshida, S., Hiyama, T., Ueno, Y., Ito, M., Kitadai, Y., Yoshihara, M., & Chayama, K. (2010). A water-soluble extract from culture medium of Ganoderma lucidum mycelia suppresses the development of colorectal adenomas. Oncology Reports, 24(5), 1181-1188.
23. Pu, X., Qu, X., Chen, F., Bao, J., Zhang, G., & Luo, Y. (2013). Camptothecin-producing endophytic fungus Trichoderma atroviride LY357: isolation, identification, and fermentation conditions optimization for camptothecin production. Applied Microbiology and Biotechnology, 97(21), 9365-9375.
24. Sarangi, I., Ghosh, D., Bhutia, S. K., Mallick, S. K., & Maiti, T. K. (2006). Anti-tumor and immunomodulating effects of Pleurotus ostreatus mycelia-derived proteoglycans. International Immunopharmacology, 6(8), 1287-1297.
25. Seo, G. S., & Kirk, P. M. (2000). Grifolan NMF-5N, an antitumor polysaccharide from Grifola frondosa: structural analysis and mechanisms of its antitumor activity. Food Science and Biotechnology, 9(5), 322-326. 15
26. Stephenson, K., Pineda-Lucena, A., Favell, K., Kaur, B., Reid, J. C., Wijekoon, C., Cox, G., Ryan, J., Alekel, D. L., & Aluko, R. E. (2013). Vitamin D2 content and erythrocyte membrane fatty acid composition in children consuming mushrooms or a vitamin D2 supplement. British Journal of Nutrition, 109(4), 698-705.
27. Takeyama, S., Yamazaki, E., Shingu, K., Kaneko, Y., Sawada, T., Hayashi, M., Yamamoto, T., Suga, T., & Matsunaga, K. (1987). Immunomodulating effects of the water-soluble polysaccharides of Grifola frondosa. Shoyakugaku Zasshi, 41(4), 340-346.
28. Tangen, J. M., Tierens, A., Caers, J., Binsfeld, M., Olstad, O. K., Tryland, M., Schots, R., Tjønnfjord, G. E., & Van Camp, B. (2015). Immunomodulatory effects of the Agaricus blazei Murrill-based mushroom extract AndoSan in patients with multiple myeloma undergoing high dose chemotherapy and autologous stem cell transplantation: a randomized, double blind clinical study. BioMed Research International, 2015, 718539.
29. Tsai, P. W., Cheng, Y. L., Lee, I. C., Chung, C. H., Yen, F. L., Tsai, T. H., & Lin, S. Y. (2016). A single-blinded, randomised, placebo-controlled study on the hepatoprotective and immunomodulatory effects of a standardised Antrodia cinnamomea mycelium extract (Armillariella tabescens) in patients with chronic hepatitis. Food & Function, 7(3), 1015- 1023.
30. Urbain, P., Singler, F., Ihorst, G., Biesalski, H. K., & Bertz, H. (2011). Bioavailability of vitamin D₂ from UV-B-irradiated button mushrooms in healthy adults deficient in serum 25-hydroxyvitamin D: a randomized controlled trial. European Journal of Clinical Nutrition, 65(8), 965-971.
31. Valadares, F., Novaes, M. R., Cañete, R., & González-Molero, I. (2013). Effect of Agaricus sylvaticus supplementation on nutritional status and adverse effects of chemotherapy of breast cancer: a randomized, placebo-controlled, double-blind clinical trial. Indian Journal of Pharmacology, 45(3), 217-222.
32. Wambaugh, M. A., Shah, P., Lam, K. N., Alves, R., Manson McGuire, A., Proctor, L., & Turnbaugh, P. J. (2017). High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance. PLoS Biology, 15(6), e2001644.
33. Wang, S. C., Lee, D. Y., Harvala, T., Sheu, S. C., Ng, L. T., Chen, C. C., Liu, Y. C., & Wu, M. T. (2012). Anti-inflammatory activity of Pleurotus citrinopileatus. Food Chemistry, 131(4), 1176-1184.
34. Xu, K., Feng, L., Liu, S., Zhao, F., Bi, K., Zhang, Q., Zhang, X., Luan, C., Liu, J., & Zhang, H. (2013). Cyathane diterpenes from cultures of Cyathus hookeri and their neurotrophic and anti-neuroinflammatory activities. Journal of Natural Products, 76(11), 2038-2045.
35. Zhao, H., Zhang, Q., Zhao, L., Huang, X., Wang, J., & Kang, X. (2012). Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evidence-Based Complementary and Alternative Medicine, 2012, 809614.

nn[/if 1104][if 1104 not_equal=””]n

    [foreach 1102]n t

  1. [if 1106 equals=””], [/if 1106][if 1106 not_equal=””],[/if 1106]

    2. n[/foreach]

n[/if 1104]

n

nn[if 1114 equals=”Yes”]n

n[/if 1114]

n

n

[if 424 not_equal=””]Regular Issue[else]Published[/if 424] Subscription Review Article

n

n

n

n

n

International Journal of Fungi

n

[if 344 not_equal=””]ISSN: 3049-1509[/if 344]

n

n

n

nn

n

[if 2146 equals=”Yes”][/if 2146][if 2146 not_equal=”Yes”][/if 2146]n

n

n

n

n

n

n

n

n

n

n

n

n

n

n

n

n

n

n

n

n[if 1748 not_equal=””]

[else]

[/if 1748]n

n[if 1746 equals=”Retracted”]n

n

n

n

[/if 1746]n[if 4734 not_equal=””]

n

n

n

[/if 4734]n

n

Volume 02
[if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] 02
Received 28/08/2025
Accepted 09/09/2025
Published 07/10/2025
Retracted
Publication Time 40 Days

n

n

44

nn

n

n
My IP
n

PlumX Metrics

nn

n

n

n[if 1746 equals=”Retracted”]n

[/if 1746]nnn

nnn”}]