Iron Oxide/Chitosan Nanocomposite: Properties and Design for AI Enhanced Immunotherapy and Regenerative Medicine

Year : 2025 | Volume : 03 | Issue : 02 | Page : 22 32
    By

    Gizachew Diga,

  1. Professor, Department of Physics, Jimma University, Jimma, Ethopia

Abstract

Biopolymers are valuable complex materials. They attract attentions of many scientists, engineers, and medical professionals’ due to their distinguished properties for various applications. In this research, emphasis is given to Fe3O4/Chitosan nanocomposite which has desirable biophysical properties compared to pure Chitosan nanoparticles. Following the green synthesis procedures and characterization methods including thermo gravimetric analysis, AI assisted biomedical application of; Fe3O4/Chitosan nanocomposite is presented. The effect of alkali typically, KOH, in purifying Chitosan during the green synthesis process is presented. Moreover, the effect of Photon energy on biodegradation of Fe3O4/Chitosan nanocomposite in conjunction with varying Fe concentration is discussed in the synthesis procedure. In this regard, AI based approach such as deep learning and machine learning in data generating, analysis, and stimulating biomedical function of Fe3O4/Chitosan composite is seen. It is expected that doping Fe3O4/Chitosan with Fe and GQDs has influence on the properties such biodegradations, biocompatibility, sensitivity, and fluorescence is noticed. AI is also investigated for optimizing the functionality of Fe3O4/Chitosan and predicting the outcome of medical procedures. Moreover, the impact of increasing Fe concentration application of Fe3O4/Chitosan composite in immunotherapy and regenerative medicine is observed. Finally, the possibility of optimizing the biophysical properties of Fe3O4/Chitosan nanocomposite for AI assisted immunotherapy, drug delivery, and regenerative medicine is observed.

Keywords: Biopolymers, Fe3O4/Chitosan nanocomposite, green synthesis, drug delivery, immunotherapy, regenerative medicine

[This article belongs to International Journal of Cheminformatics ]

How to cite this article:
Gizachew Diga. Iron Oxide/Chitosan Nanocomposite: Properties and Design for AI Enhanced Immunotherapy and Regenerative Medicine. International Journal of Cheminformatics. 2025; 03(02):22-32.
How to cite this URL:
Gizachew Diga. Iron Oxide/Chitosan Nanocomposite: Properties and Design for AI Enhanced Immunotherapy and Regenerative Medicine. International Journal of Cheminformatics. 2025; 03(02):22-32. Available from: https://journals.stmjournals.com/ijci/article=2025/view=229536


References

  1. Rona Cuana et al. Green synthesis of Fe3o4/Chitosan Nanoparticles utilizing Morninga Oleifera Extract and their surface Plasmon Resonance properties. ECS. J. Solid State Sci. Technol. 2022, V.11,083015.doi:10.1149/2162-8777/ac8b36.
  2. Huong N T., et al. Fe3O4/CuO/Chitosan nanocomposites; An Ultrasound –assisted Green approach for antibacterial and phtocatalytic activity. ACS. 2023, V-8, Issn-45, pages
  3. Antony Arockiaraj et al. Effect of Chitosan incorporated Fe3O4 nanocomposite on the Photocatalytic removal of organic molecules. J Mater Sci. Mater Electron. 2022, V. 33, 9570-9579. https://doi.org/10.1007/s10854-07579-7.
  4. Rona Cuana et al. Green synthesis of Fe3O4/Chitosan nanoparticles utilizing Moringa oleifera Extract and their surface Plasmon resonance properties. ECS J, Solid State Sci.Technol. 2022, 11 0830 15.
  5. M. Freire et al. Fast ultrasound assisted synthesis of Chitosan based magnetite nanocomposite as a modified electrode sensors. Carbohydrates and polymers. 2016, V. 151, 760-769.
  6. Louis S T et al. Polymeric drug delivery techniques. Material Science. 2015, (314) 771-5765
  7. Soares, P. I., Machado, D., Laia, C., Pereira, L. C., Coutinho, J. T., Ferreira, I. M., Novo, C. M., & Borges, J. P. Thermal and magnetic properties of Chitosan-iron oxide nanoparticles. Carbohydrate Polymers. 2016, 149, 382 390.https://doi.org/10.1016/j.carbpol. 2016. 04. 123
  8. Islam et al. Chitin and Chitosan: Structure, Properties and Applications in Biomedical Engineering. J Polymer Environ. 2017, 25:854 – 866
  9. Vo LQ, Vu AT LeTD, Huynh CD, Tran HV. Fe3O4Graphene oxide/Chitosan nanocomposites: Asmart nanoabsorbet for lead(II) iron removal from contaminated water. ACS Omega. 2024,Apr. 3; 9(15):17506-17517. Doi:10.1021/acsomega. 4c00c486.
  10. G Sarojini et al. Biofabrication of porous magnetic Chitosan/Fe3O4 nanocomposite using Azolla pinnata for removal of Chromium parametric effects, surface characterization and kinetics.Environmental research. 2023, V. 218, 114822.
  11. Nathan R. Zaccai, Joseph Zaccai, and Igor N. Serdyuk. Methods in Molecular biophysics. 2017, 2, ISBN 978-1-107-05637-4
  12. Alain Dufresne, Sabu Thomas, Laly A. Pothen (2013). Biopolymer Nanocomposite: Processing, Properties, and Applications. John Wiley & Sons, Inc. ISBN: DOI:10.1002/9781118609958
  13. Tiama T M. et al. Structural and spectroscopic studies of Chitosan/Fe3O4 nanocomposite as Glycine Biosensor. Biointerface Research in Applied Chemistry. 2023. Vol. 13, Issue 6, 2023, 547. https://doi:10.33263/briac13.547.
  14. Meyer B. Jackson. Molecular and cellular biophysics. 2006, ISBN-13 978-0-511-34472-5
  15. Ulf W. Geddes. Polymer physics. Springer, Science and business media. 1999, ISBN 978-0-412-62640-1
  16. Qu, J., Liu, G., Wang, Y., & Hong, R. (2010). Preparation of Fe3O4/Chitosan nanoparticles used for hyperthermia. Advanced Powder Technology, 21(4), 461-467. https://doi.org/10.1016/j.apt.2010.01.008
  17. Gustavo Adolfo Munoz Ruiz et al. Chitosan, Chitosan Derivatives and their Biomedical Applications. 2016, 3. 249.
  18. Siti Hajar Othman et al., Bio-nanocomposite Materials for Food Packaging Applications: Types of Biopolymer and Nano-sized Filler. 2014 V. 2, Pp. 296-303
  19. Pourmadadi, M., Ahmadi, M., & Yazdian, F. (2023). Synthesis of a novel pH-responsive Fe3O4/chitosan/agarose double nanoemulsion as a promising Nanocarrier with sustained release of curcumin to treat MCF-7 cell line. International Journal of Biological Macromolecules, 235, 123786. https://doi.org/10.1016/j.ijbiomac.2023.123786
  20. Noura El ‑ Ahmady El ‑ Naggar et al. Green synthesis of Chitosan nanoparticles, optimization, characterization and antibacterial efficacy against multi drug resistant biofilm-forming Acinetobacterbaumannii, Scientific Reports. 2022, 12:19869.
  21. Gomes L. P. et al. Chitosan Nanoparticles: production, physicochemical characteristics and Nutraceutical applications. Rev. Virtual Quim. 2017, 9 (1), 387-409.
  22. Belen Begines et al. Polymeric Nanoparticles for Drug Delivery. 2020, 10, 1403
  23. Korhegyi Z., Rozsa D, Hajdu I, Bodnar M, Kertesz I, Kerekes K, KunS, Kollar J, Varga J, Garai J, Trencsenyi G, Borbely J. Synthesis of 68ga-labeled biopolymer-based nanoparticles imaging agents for positron-emission tomography. Anticancer Res. 2019, 39: 2415-2427. Doi:10.21873/anticanceres.13359.PMID:31092434.
  24. Tia Y et al. applications of Chitosan and its derivatives in skin and soft tissue disease. Front. Bioengineering, Biotechnology. 2022, V. 10, 894 667.
  25. Kim et al. Dispersion of Chitosan nanoparticles stable over a wide pH range by adsorption of polyglycerolmonostearate. Nanomaterials and Nanotechnology. 2020, V. 10: 1-9
  26. Zahra Fakhroueian et al. ZnO Q-dots as a potent therapeutic nanomedicine for in vitro cytotoxicity evaluation of mouth KB44, breast MCF7, colon HT29 and HeLa cancer cell lines, mouse ear swelling tests in vivo and its side effects using the animal model, Artificial cells, Nanomedicine, and Biotechnology. 2018, vol. 46, №. S2, S 96 -S111.
  27. Ding J & Guo Y, Recent Advances in Chitosan and its Derivatives in Cancer Treatment Front. Pharamacol. 2022; 13: 888740.
  28. Carmen P. Jimenez Gomez and Juan Antonio Cecilia, Chitosan: A Natural Biopolymer with a Wide and Varied Range of Applications 2020, 25, 3981.
  29. L Kakani and Amit Kakani, Material science. 2004, ISBN (13) Pages 657.
  30. Krepsztul J W., et al. Biopolymers for Biomedical and Pharmaceutical Applications: Recent advances and overview of alginate electro spinning. 2019, 9, 404, https:/doi.org/10.3390/nano9030404.
  31. Zhang, Yin-Juan Gao Bo, Liu, Xi-Wen. Topical and effective homeostatic medicine in the battlefield. J. Clin Exp Med. 2015, 8 (1): 1019.
  32. Dwivedi et al. Application of polymer nanocomposite in the nanomedicine landscape: envisaging strategies to combat implant-associated infections Appl. Biomater Funct Mater 2013, 11 (3): 129-142.
  33. Gökçen Yaşayan. Chitosan films and Chitosan/pectin polyelectrolyte complexes encapsulating silver sulfadiazine for wound healing. J Pharm. 2020, 50 (3): 238-244.
Regular Issue Subscription Review Article
Volume 03
Issue 02
Received 23/06/2025
Accepted 08/10/2025
Published 20/10/2025
Publication Time 119 Days
162

Login


My IP

PlumX Metrics