International Journal of Cheminformatics

Non-alcoholic fatty liver disease (NAFLD) affects about one-third of the population in the United States and Western countries, reaching up to 90% among obese individuals and those undergoing bariatric surgery.

The transformational potential of merging spintronics and Micro-Electromechanical Systems (MEMS) technologies in cheminformatics is investigated in this work.

The endocannabinoid system plays a crucial role in numerous physiological functions, making cannabinoid receptor 1 (CB1) an attractive target for therapeutic development. This review provides a systematic analysis of patent filings from 2019 to 2023 that focus on small-molecule CB1 reverse agonists. It begins with an overview of the endocannabinoid system, highlighting CB1’s involvement in energy balance, pain regulation, and neuroinflammatory processes The main section of the review examines fifteen patents covering diverse structural classes—such as pyrazoles, triazoles, and piperidines—designed to achieve high CB1 affinity and efficacy.

Biopolymers are valuable complex materials. They attract attentions of many scientists, engineers, and medical professionals’ due to their distinguished properties for various applications.

Hetercyclic compounds play a vital role in both chemical and life sciences. Among them ,thiazolidinone represent a significant class, characterized by a five- membered saturated ring containing both sulfur and nitrogen atoms.

Crop diseases contribute to major losses in agricultural production worldwide generating enormous economic costs.