Antibiotics in the Modern Era: Challenges, Misuse, and the Fight Against Resistance

Year : 2025 | Volume : 02 | Issue : 01 | Page : 57 70
    By

    Satish Kumar Sarankar,

  • Sushma Somkuwar,

  1. Professor, Faculty of Pharmacy, Mansarovar Global University, Sehore, M.P. -466111, India
  2. Associate Professor, School of Pharmacy, LNCT University, Bhopal, M.P. – 462042, India

Abstract

Overuse and inappropriate use of antibiotics in human medicine, agriculture, and environmental pollution. It is one of the biggest public health risks of the 21st century. The discovery of new antibiotics slowdown and the emergence of multidrug-resistant (MDR) microorganisms has highlighted the urgent need to Creative approaches to fighting opposition. This review explores the current challenges in antibiotic use, the factors driving resistance, and the strategies being implemented to address these issues. We examine the role of antibiotics in modern medicine, highlighting their indispensable role in treating infections but also acknowledging the increasing risks associated with their misuse. unusual trade international travel and the misuse of antibiotics in agriculture. It greatly facilitates the spread of drug-resistant bacteria.The economic and scientific challenges hindering the development of new antibiotics are also discussed, along with emerging approaches to incentivize research and development. Key strategies for combating AMR include improving stewardship practices, implementing regulatory measures, and developing alternative treatments such as vaccines, antimicrobial peptides (AMPs), and AI-driven drug discovery. We also review innovative interventions like the use of phage therapy and immune modulators. The article highlights the importance of a multifaceted approach, combining regulatory frameworks, scientific innovation, and global collaboration to mitigate the threat of AMR. Case studies such as Denmark’s successful ban on growth promoters and MIT’s AI-driven discovery of halicin provide valuable insights into potential solutions. Despite the challenges, promising advancements offer hope for overcoming the AMR crisis, but global cooperation and sustained investment in research are essential for long-term success in combating resistant infections.

Keywords: Antimicrobial resistance (AMR), Antibiotic misuse, Multidrug-resistant bacteria, Antibiotic stewardship, Alternative therapies, Antibiotic discovery, Global health

[This article belongs to International Journal of Antibiotics ]

How to cite this article:
Satish Kumar Sarankar, Sushma Somkuwar. Antibiotics in the Modern Era: Challenges, Misuse, and the Fight Against Resistance. International Journal of Antibiotics. 2024; 02(01):57-70.
How to cite this URL:
Satish Kumar Sarankar, Sushma Somkuwar. Antibiotics in the Modern Era: Challenges, Misuse, and the Fight Against Resistance. International Journal of Antibiotics. 2024; 02(01):57-70. Available from: https://journals.stmjournals.com/ijab/article=2024/view=190175


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Regular Issue Subscription Review Article
Volume 02
Issue 01
Received 30/11/2024
Accepted 14/12/2024
Published 18/12/2024
Publication Time 18 Days
325

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