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Research & Reviews: A Journal of Drug Design & Discovery Cover

Research & Reviews: A Journal of Drug Design & Discovery

ISSN: 2349-9036


Focus and Scope

About the Journal

Research & Reviews: A Journal of Drug Design & Discovery [2349-9036(e)] is a peer-reviewed hybrid open access journal launched in 2014 covers the latest research on how drugs work, rational approaches such as Structure-based drug design, Molecular approaches to optimization of Drug Delivery, and encompasses a wide range of recent Drug advancements involving.

Focus and Scope

  • Analog-based drug design: Directanaloges, me-too drugs, structural analogs, functional analogs, bioisosteric modifications, design of rigid analogs, homologation of alkyl chains, alteration of chain branching, design of aromatic ring position isomers, alteration of the ring size, the substitution of the aromatic ring for a saturated one, alteration of stereochemistry, design of geometric isomers and stereoisomers, bond disconnection.
  • Clinical and medicinal chemistry: design, synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, structural biological studies, novel computational chemistry methods, quantitative structure-function relationship, combinatorial chemistry, analytical chemistry, biochemistry, biosynthesis, catalysis, organic synthesis, medicinal organic chemistry, synthetic medicinal chemistry, anticancer agents in medicinal chemistry, medicinal chemical research, chemical pharmacology, pharmacy analysis, pharmaceutical manufacturing, pharmaceutical chemistry, drug monitoring and analysis, evaluation of diagnostic biomarkers, synthetic chemistry, bioorganic chemistry, structural characterization, metabolic transformation.
  • Drug extraction: Cold extraction methods, enzyme-assisted extraction, plant tissue homogenization, ionic liquid extraction, high-temperature extraction methods, decoction, soxhlet extraction, microwave-assisted extraction, automated solvent digester extraction, pressurized liquid extraction, serial exhaustive extraction, infusion and digestion, supercritical fluid extraction, sonication, drug-drug interaction extraction, relation extraction, long and short term memory attention mechanism, laboratory-based green extraction techniques of medicinal plants.
  • Drug safety assessment: Patient suitability for safety in clinical trials, regulatory aspects of drug safety, causality, risk assessment, post-marketing safety of drug products, abuse liability and substance, in vitro and in vivo CV assessments, Infusion studies, ICH Core battery test, contentious and emerging issues, epidemiology, clinical features, prevention and management of adverse effect of drugs, in-depth benefit-risk assessment of adverse effect and efficacy data for a drug, PRISMA statement, post-market surveillance, pharmacoeconomics, molecular pharmacoepidemiology, assessment of benefit-risk in drug therapy, patterns of drug utilization, risk management plans.
  • Fragment-based drug discovery: Covalent linkage, dynamic combinatorial chemistry, optimized fragments, screening of specialized fragments, quantitative assessment of binding (Kd), 3d analysis of ligands, a quality check of fragment libraries, Mnova Gears, Cocktail design, MixDesign, SampleJet, CryoProbes (QCIF), Mnova Screen, Lead Optimization, Mnova StereoFitter, qNOE, chemical shift, J coupling. 
  • Pharmaceutical analysis: Liquid chromatography techniques, adsorption chromatography, partition chromatography, affinity chromatography, ion chromatography, size exclusion chromatography, planer chromatography techniques, paper chromatography, thin layer chromatography, column and pressurized techniques, high-performance liquid chromatography, high-performance thin layer chromatography, optimum performance lamina chromatography, gas chromatography, immunoassay, structure elucidation using spectroscopic techniques, Fourier transformation infrared spectroscopy, nuclear magnetic resonance, mass spectrometry. 
  • Pharmaceutical screening process: Differential scanning fluorimetry (DSF), Isothermal titration calorimetry (ITC), Nuclear magnetic resonance (NMR), surface plasmon resonance (SPR), X-ray crystallography, standard and customizable H1, and F19 NMR screening experiments, agar disk diffusion methods, poisoned food method, dilution method, Adenosine triphosphate bioluminescence assay, flow cytometry, antibiofilm formation, anti quorum sensing bioassay, anti-parasitic assay, high throughput screen, high content screening, virtual screening methods.
  • Structure-based drug discovery: Ligand-based drug design, database searching, receptor-based drug design, lead compound, molecular docking, virtual screening, surface representation, surface matching, pose prediction, monte Carlo method, molecular dynamics, simulated annealing, genetic algorithms, hit identification, lead optimization, bioremediation, de novo drug design, linking, lattice-based method, site point connection method, sequential build-up methods, target protein, and binding site identification, lead identification approach, scoring functions, machine learning, artificial intelligence in drug discovery.
  • In silico drug discovery: Homology model, ADME/Tox, Bioactivity, toxicity, deep learning, variational autoencoder, random forest, artificial neural network, deep neural network, GlaxoSmithKline, recurrent neural network, Qualitative structure-activity relationship (QSAR), Quantitative estimate of drug likeliness (QED), Simplified molecular-input line-entry-system (SMILES), descriptor-based methods, 3d-QSAR, comparative molecular field analysis, comparative molecular similarities, rule-based methods, knowledge-based approaches, virtual affinity profiling, data visualization, Computer-aided drug design (CADD), toxicity prediction, in silico modeling, high throughput screening, pre-clinical lead optimization, clinical leadership development. 
  • Types of pharmaceutical drugs: next-generation targeted therapies, gene therapies, personalized medicines, non-steroidal anti-inflammatory drugs (NSAIDs), Over the counter NSAIDs, prescription NSAIDs, Schedule II opioid drugs, analgesics, anesthetics, anti-addiction agents, antiparkinson agents, antipsychotics, antispasticity agents, hormonal agents, antibacterials, anticonvulsants, antidementia agents, antivirals, anxiolytics, bipolar agents, antidepressants, antiemetics, antifungals, blood glucose regulators, blood products, cardiovascular agents, immunological agents, infertility agents, antigout agents, anti-inflammatories, central nervous system agents, contraceptives, inflammatory bowel disease agents, metabolic bone disease agents, antimigraine agents, antimyasthenic agents, dental and oral agents, dermatological agents, ophthalmic agents, otic agents, antimycobacterial, electrolytes, minerals, vitamins, metals, respiratory tract agents, antineoplastics, gastrointestinal agents, sexual disorder agents, anti-obesity agents, genitourinary agents, skeletal muscle relaxants, antiparasitics, sleep disorder agents.