Research & Reviews: A Journal of Drug Design & Discovery

Research & Reviews: A Journal of Drug Design & Discovery

Research & Reviews: A Journal of Drug Design & Discovery [2349-9036(e)] is a peer-reviewed hybrid open access journal launched in 2014 covers the latest research on how drugs work, rational approaches such as Structure-based drug design, Molecular approaches to optimization of Drug Delivery, and encompasses a wide range of recent Drug advancements involving.

The journal welcomes contributions across the following topic areas:

• Structure-Based Drug Discovery: receptor and protein target identification, ligand-based drug design and database searching, receptor-based drug design approaches, molecular docking and pose prediction, virtual screening and hit identification, surface representation and matching, scoring functions and binding prediction, Monte Carlo and molecular dynamics simulations, simulated annealing and genetic algorithms, lead identification and optimization, de novo drug design, sequential build-up methods, and computational methods validation.
• In Silico Drug Discovery & Computational Chemistry: computer-aided drug design and molecular modeling, quantitative structure-activity relationship and QSAR analysis, 3D-QSAR and comparative molecular field analysis, toxicity prediction and bioactivity assessment, ADME/Tox prediction and drug-likeness assessment, deep learning and machine learning applications, neural networks and artificial intelligence in drug discovery, random forest and decision tree methods, virtual affinity profiling and data visualization, toxicity prediction from structure, and implementation in pre-clinical lead optimization.
• Fragment-Based Drug Discovery: fragment screening and optimization, quantitative binding assessment and Kd determination, covalent linkage and fragment linking, dynamic combinatorial chemistry, 3D analysis of fragment ligands, fragment library quality and design, cocktail screening and MixDesign approaches, lead optimization from fragments, NMR-based screening and chemical shift analysis, J coupling analysis, and outcomes in hit-to-lead progression.
• Analog-Based Drug Design: direct analogs and me-too drug development, structural and functional analogs, bioisosteric modifications and ring substitution, rigid analog design, homologation and alkyl chain extension, aromatic ring position isomers, ring size alteration and saturation, stereochemistry modification, geometric and stereoisomers, and rational analog design approaches.
• Medicinal Chemistry & Synthesis: design, synthesis, and biological evaluation of novel compounds, structural modification and optimization, organic synthesis and bioorganic chemistry, synthetic medicinal chemistry approaches, anticancer and antiviral agents, computational chemistry methods and validation, analytical chemistry and structural characterization, biosynthesis and catalysis, metabolic transformation assessment, and bioactivity and potency evaluation.
• Pharmaceutical Analysis & Characterization: liquid chromatography and HPLC techniques, high-performance thin layer chromatography, gas chromatography and mass spectrometry, adsorption and partition chromatography, ion-exchange and size-exclusion chromatography, affinity chromatography and immunoassay, spectroscopic techniques and structure elucidation, Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and method validation and quality assessment.
• Pharmaceutical Screening & Assays: differential scanning fluorimetry and isothermal titration calorimetry, surface plasmon resonance and X-ray crystallography, high-throughput screening and high-content screening, flow cytometry and cell-based assays, antibiofilm and anti-quorum sensing assays, agar disk diffusion and microbial susceptibility testing, poisoned food and dilution methods, adenosine triphosphate bioluminescence assay, anti-parasitic and antifungal assays, and assay development and validation.
• Drug Extraction & Isolation: extraction methods from natural products and plants, cold extraction and enzyme-assisted extraction, plant tissue homogenization and processing, ionic liquid extraction and green chemistry approaches, high-temperature extraction and supercritical fluid extraction, microwave-assisted and pressurized liquid extraction, soxhlet extraction and serial exhaustive extraction, infusion and decoction methods, sonication and laboratory automation, and bioactive compound isolation and purification.
• Drug Safety Assessment & Pharmacovigilance: patient suitability and clinical trial safety, regulatory aspects and compliance, causality assessment and adverse event attribution, post-marketing surveillance and pharmacoeconomics, abuse liability and substance use evaluation, in vitro and in vivo cardiovascular safety assessment, ICH core battery testing and preclinical safety, benefit-risk assessment and PRISMA statements, molecular pharmacoepidemiology, adverse effect prevention and management, and risk management plans and post-market surveillance.
• Pharmaceutical Drug Classes & Therapeutic Agents: next-generation targeted therapies and personalized medicines, gene therapies and biotherapeutics, non-steroidal anti-inflammatory drugs and analgesics, opioid and anesthetic agents, antiparkinson and antipsychotic agents, antidepressants and anxiolytics, anticonvulsants and antiemetics, antivirals and antimycobacterials, antibacterials and antifungals, cardiovascular and metabolic agents, immunological and infertility agents, gastrointestinal and respiratory agents, dermatological and ophthalmic agents, and oncology and anti-cancer agents.