Formulation and Evaluation of Betel Leaf and Clove Based Herbal Gel

Year : 2026 | Volume : 13 | 02 | Page :
    By

    Parmar Harshul,

  • Varma Vishnu,

  • Yadav Laxmi,

  • Shubham Singh,

  • Sanjesh Rathi,

  1. Student of B Pharmacy, Department of School of Pharmacy, Rai University, Ahmedabad, Guajarat, India
  2. Student of B Pharmacy, Department of School of Pharmacy, Rai University, Ahmedabad, Guajarat, India
  3. Student of B Pharmacy, Department of School of Pharmacy, Rai University, Ahmedabad, Guajarat, India
  4. Assistant Professor, Department of Pharmaceutics, School of Pharmacy, Rai University, Ahmedabad, Guajarat, India
  5. Professor and Principal, Department of Pharmaceutics, School of Pharmacy, Rai University, Ahmedabad, Guajarat, India

Abstract

This study developed and assessed a herbal gel comprising extracts of betel leaf (Piper betle) and clove (Syzygium aromaticum) for topical use. Herbal extracts were prepared by Soxhlet extraction and analyzed for yield, phytochemical profile and total phenolic content (TPC). The phytochemicals present were alkaloids, flavonoids, tannins and phenols, and glycosides, with a greater phenolic content for clove extract. Herbal gels were prepared using Carbopol 934 and assessed for properties, drug content, drug release, and biological activity. The formulations had an acceptable range of pH (6.2-6.7), uniformity, and satisfactory values of viscosity and spreadability. The drug content uniformity was between 96.2% to 98.3%, and showed the homogeneity of active constituents. The in vitro release of the drug from the formulations was found to be 81.6% (F3) after 6 hours. The antimicrobial test results showed a dose-dependent increase. Formulation F3 performed best with regard to drug release and physicochemical characteristics. The research suggests the formulated betel leaf and clove herbal gel is an effective, cost-effective and stable natural product for topical use.

Keywords: Herbal gel; Piper betle; Syzygium aromaticum; Phytochemical screening; Carbopol 934; In vitro drug release; Drug content uniformity

How to cite this article:
Parmar Harshul, Varma Vishnu, Yadav Laxmi, Shubham Singh, Sanjesh Rathi. Formulation and Evaluation of Betel Leaf and Clove Based Herbal Gel. Research & Reviews: A Journal of Pharmacognosy. 2026; 13(02):-.
How to cite this URL:
Parmar Harshul, Varma Vishnu, Yadav Laxmi, Shubham Singh, Sanjesh Rathi. Formulation and Evaluation of Betel Leaf and Clove Based Herbal Gel. Research & Reviews: A Journal of Pharmacognosy. 2026; 13(02):-. Available from: https://journals.stmjournals.com/rrjopc/article=2026/view=242722


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Ahead of Print Subscription Original Research
Volume 13
02
Received 25/04/2026
Accepted 01/04/2026
Published 03/05/2026
Publication Time 8 Days
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