Synthesis, Identification and Bio Evaluation of New Thiophene Derivatives

Year : 2026 | Volume : 17 | Issue : 01 | Page : 31 43
    By

    Rabab Mahdi Ubaid Mahmood,

  • Wisam Hassan Ali Alfartosi,

  • Noor Sabah Muttaleb,

  • Dr. Nagham Mahmood Aljamali,

  1. Assistant Lecturer, Education Ministry, Al Mustafa School, Baghdad, Iraq
  2. Assistant Lecturer, Department of Organic Chemistry, Faculty of Agriculture, University of Kufa, Kufa, Iraq
  3. Assistant Lecturer, Department of Chemistry, College of Education for Girls, University of Kufa, Kufa, Iraq
  4. Professor, Department of Chemistry, College of Education for Girls, University of Kufa, Kufa, Iraq

Abstract

Thiophene is considered one of the most effective cyclic sulfur compounds in organic and pharmaceutical chemistry due to its high stability in various chemical reactions. It plays a key role as an antifungal agent in treating skin allergies, as well as in the preparation of polymers, rubber, and other materials. Recent research has focused on incorporating sulfur compounds into the synthesis of organic compounds because of their high stability in manufactured materials. The combination of thiophene and chalcone within a single pharmaceutical derivative or compound provides highly effective therapeutic properties against various types of bacteria, particularly those causing skin, oral, and dental infections. Sulfur derivatives, including benzothiazole and thiophene, are known for their bactericidal effects. Furthermore, the electron pair on the sulfur atom adds another biological property, giving these derivatives medicinal properties that target many infectious viruses. The current research involved the preparation of thiophene compounds linked with anile, chalcone, and di molecules of chalcone, as well as thiophene linked to cyclic derivatives such as imidazole and others, the methods for preparing these materials vary depending on the type of raw materials, the solvents used, and the reaction conditions, such as the temperature and pressure required to complete the preparation process. As is well known, to characterize and validate the synthesis of any chemical compound, researchers resorted to spectroscopic methods, including proton resonance spectroscopy, carbon resonance spectroscopy, and infrared spectroscopy, in addition to biological studies. Furthermore, theoretical studies were conducted to compare with experimental results obtained to demonstrate the efficacy of the synthesized compounds.

Keywords: thiophene, chalcone, anile, thiazole, infrared spectroscopy.

[This article belongs to Journal of Modern Chemistry & Chemical Technology ]

How to cite this article:
Rabab Mahdi Ubaid Mahmood, Wisam Hassan Ali Alfartosi, Noor Sabah Muttaleb, Dr. Nagham Mahmood Aljamali. Synthesis, Identification and Bio Evaluation of New Thiophene Derivatives. Journal of Modern Chemistry & Chemical Technology. 2026; 17(01):31-43.
How to cite this URL:
Rabab Mahdi Ubaid Mahmood, Wisam Hassan Ali Alfartosi, Noor Sabah Muttaleb, Dr. Nagham Mahmood Aljamali. Synthesis, Identification and Bio Evaluation of New Thiophene Derivatives. Journal of Modern Chemistry & Chemical Technology. 2026; 17(01):31-43. Available from: https://journals.stmjournals.com/jomcct/article=2026/view=236718


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Regular Issue Subscription Original Research
Volume 17
Issue 01
Received 17/01/2026
Accepted 20/01/2026
Published 14/02/2026
Publication Time 28 Days
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