5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-4-one: Synthesis and Reactions

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Year : 2025 | Volume : 16 | 03 | Page :
    By

    Khalid M. Darwish,

  • Ahmed M. Ahmed,

  1. Professor, Department of Chemistry, University of Benghazi, Benghazi, Libya, North Africa
  2. B.Sc Graduate Student, Department of Chemistry, University of Benghazi, Benghazi, Libya, North Africa

Abstract

The presence of the five-member pyrazole nucleus in different structures leads to a large diversity in its applications. In almost every research study, the pyrazole derivatives biological importance faces a competitive challenge in areas of technology, medicine and agriculture. This reflects the description of these derivatives as antibacterial, antifungal, anticancer, antidepressant, anti-inflammatory, anti-tuberculosis, antioxidant as well as antiviral agents. In our review, we will discuss and show the highlights of chemical structure and tautomerism, the general methods of preparation of methyl-2-phenyl-2,4-dihydro-3H-pyrazol-4-one as the core compound, including its synthesis from the β-Ketoesters and hydrazine derivatives and cyclization through hydrazone intermediates and the microwave-assisted and solvent-free synthesis. In addition, we will provide a close idea of derivatives of 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-4-one and present them as N-substituted and C-substituted derivatives, metal complexes as well as azo-dyes and chromophores. In the second part of this review, we will discuss the reactions of methyl-2-phenyl-2,4-dihydro-3H-pyrazol-4-one such as the azo-coupling reactions, condensation reactions, alkylation, acylation and halogenation reactions, complex formation with metals in addition to the oxidation and reduction reactions. At the end of our review we will mention the applications and importance of this compound and its derivatives and their use across numerous scientific and industrial fields such as medicinal chemistry, dye and pigment synthesis, analytical chemistry assays, metal complexing agents, catalysts and sensors, synthetic intermediates, fluorescent materials, organic semiconductors and reactive monomers.

Keywords: Pyrazolones, Hydrazines, N-Substituted, C-Substituted, Alkylation, Azo dyes

How to cite this article:
Khalid M. Darwish, Ahmed M. Ahmed. 5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-4-one: Synthesis and Reactions. Journal of Modern Chemistry & Chemical Technology. 2025; 16(03):-.
How to cite this URL:
Khalid M. Darwish, Ahmed M. Ahmed. 5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-4-one: Synthesis and Reactions. Journal of Modern Chemistry & Chemical Technology. 2025; 16(03):-. Available from: https://journals.stmjournals.com/jomcct/article=2025/view=235073


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Ahead of Print Subscription Review Article
Volume 16
03
Received 28/11/2025
Accepted 22/12/2025
Published 26/12/2025
Publication Time 28 Days
134

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