This is an unedited manuscript accepted for publication and provided as an Article in Press for early access at the author’s request. The article will undergo copyediting, typesetting, and galley proof review before final publication. Please be aware that errors may be identified during production that could affect the content. All legal disclaimers of the journal apply.
Adebayo Samuel,
Abstract
The emergence of biopolymer-based nanoparticles, particularly those composed of proteins and polysaccharides, has significantly transformed the landscape of biocompatible and biodegradable materials. These nanoparticles offer immense potential due to their ability to facilitate encapsulation and targeted delivery of bioactive compounds, enhancing therapeutic efficacy while minimizing side effects. This review explores the various fabrication techniques, including emulsification, desolvation, coacervation, and electrospray drying, emphasizing their advantages and limitations. The characterization of nanoparticles based on critical parameters such as size, surface charge, morphology, stability, and controlled release properties is discussed in detail, along with advanced analytical techniques for measurement. Furthermore, this article delves into the diverse biomedical applications of these nanoparticles, including drug delivery, wound healing, tissue engineering, and vaccine development. The review also highlights current challenges and future perspectives, focusing on scalability, regulatory considerations, and novel formulations that integrate multiple functionalities for enhanced performance. With ongoing advancements in nanotechnology and material science, biopolymer-based nanoparticles continue to be a promising avenue for various biomedical applications, fostering innovation in targeted therapies and regenerative medicine.
Keywords: Biopolymers, Nanoparticles, Encapsulation, Controlled release, Biomedical applications
[This article belongs to International Journal of Photochemistry and Photochemical Research (ijppr)]
Adebayo Samuel. Biopolymer-Based Nanoparticles: Advances in Fabrication, Characterization, and Biomedical Applications. International Journal of Photochemistry and Photochemical Research. 2025; 03(01):-.
Adebayo Samuel. Biopolymer-Based Nanoparticles: Advances in Fabrication, Characterization, and Biomedical Applications. International Journal of Photochemistry and Photochemical Research. 2025; 03(01):-. Available from: https://journals.stmjournals.com/ijppr/article=2025/view=0
References
- Majumdar S, Basu S K. Antimicrob. Agents Chemother. 1991; 35:135.
- Nakagawa Y, Takayama K, Ueda H, Machida Y, Nagai T. Drug Des. Deliv. 1987; 2:99.
- Segura S, Espuelas S, Renedo M J, Irache J M. Drug Dev. Ind. Pharm. 2005; 31:271.
- Irache J M, Merodio M, Arnedo A, Camapanero M A, Mirshahi M, Espuelas S. Mini-Rev. Med. Chem. 2005; 5:293.
- Santhi K, Dhanaraj S A, Joseph V, Ponnusankar S, Suresh B. Drug Dev. Ind. Pharm. 2002; 28:1171.
- Kreuter J, Hekmatara T, Dreis S, Vogel T, Gelperina S, Langer K. J. Control. Release 2007; 118:54.
- Merodio M, Irache J M, Eclancher F, Mirshahi M, Villarroya H. J. Drug Target. 2000; 8:289.
- Lynn A K, Yannas I V, Bonfield W. J. Biomed. Mater. Res. B: Appl. Biomater. 2004; 71B:343.
- Barbani N, Giusti P, Lazzeri L, Polacco G, Pizzirani G. J. Biomater. Sci. Polym. Ed. 1995; 7:461.
- Lefebvre F, Gorecki S, Bareille R, Amedee J, Bordenave L, Rabaud M. Biomaterials 1992; 13:28.
- Ruderman R J, Wade C W R, Shepard W D, Leonard F. J. Biomed. Mater. Res. 1973; 7:263.
- Bender A, von Briesen H, Kreuter J, Duncan I B, Rubsamen-Waigmann H. Antimicrob. Agents Chemother. 1996; 40:1467.
- Schwick H G, Heide K. Bibl. Haematol. 1969; 3:111.
- Ward A G, Courts A. The Science and Technology of Gelatin. New York: Academic Press; 1977.
- Bajpai A K, Choubey J. J. Mater. Sci: Mater. Med. 2006; 17:345.
- Stevens K R, Einerson N J, Burmania J A, Kao W J. J. Biomater. Sci. Polym. Ed. 2002; 13:1353.
- Marios Y, Chakfe N, Deng X, Marios M, How T, King W, Guidoin R. Biomaterials 1995; 16:1131.
- DiSilvio L, Courtney-Harris R G, Downes S. J. Mater. Sci., Mater. Med. 1994; 5:819.
- Sinohara H, Asano Y, Fukui A. Biochem. Biophys. Acta 1971; 237:273.
- Asakura T, Kaplan D L. Encyclopedia of Agricultural Science. Vol. 4. New York: Academic Press; 1994. p. 1.
- Lotz B, Colonna-Cesari F. Biochemie 1979; 61:205.
- Altman G H, Diaz F, Jakuba C, Calabro T, Horan R L, Chen J, Lu H, Richmond J, Kaplan D L. Biomaterials 2003; 24:401.
- Kundu J, Chung Y I, Kim Y H, Tae G, Kundu S C. Int. J. Pharm. 2010; DOI: 10.1016/j.ijpharm.2009.12.052.
- Vepari C, Kaplan D L. Prog. Polym. Sci. 2007; 32:991.
- Kundu J, Patra C, Kundu S C. Mater. Sci. Eng. C 2008; 28:1376.
- Kundu J, Dewan M, Ghoshal S, Kundu S C. J. Mater. Sci., Mater. Med. 2008; 19:2679.
- Kaplan D L, Mello C M, Arcidiacono S, Fossey S, Senecal K, Muller W. Protein-Based Materials. Boston: Birkhauser; 1997. p. 103.
- Sofia S, McCarthy M B, Gronowicz G, Kaplan D L. J. Biomed. Mater. Res. 2001; 54:139.
- Shao Z, Vollrath F. Nature 2002; 418:741.
- Sinohara H. Comput. Biochem. Physiol. 1979; 63B:87.
- Kundu S C, Dash B C, Dash R, Kaplan D L. Prog. Polym. Sci. 2008; 33:998.
- Gamo T, Inokuchi T, Laufer H. Insect Biochem. Mol. Biol. 1977; 7:285.
- Tokutake S. Biochem. J. 1980; 187:413.
- Takasu Y, Yamada H, Tsubouchi K. Biosci. Biotechnol. Biochem. 2002; 66:2715.
- Michaille J J, Couble P, Prudhomme J C, Garel A. Biochemie 1986; 68:1165.
- Tsukada M, Bertholon G. Bull. Sci. Inst. Text. Fr. 1981; 10:141.
- Mandal B B, Priya A S, Kundu S C. Acta Biomater. 2009; 5:3007.
- Dash B C, Mandal B B, Kundu S C. J. Biotechnol. 2009; 144:321.
- Bunning T J, Jiang H, Adams W W, Crane R L, Farmer B, Kaplan D L. Silk Polymers—Material Science and Biotechnology: ACS Symposium Series 544. Washington, DC: American Chemical Society; 1993. p. 353.
- Mandal B B, Kundu S C. Nanotechnology 2009; 20:355101.
- Suzuki N, et al. Biofactors 2004; 21:329.
- Dash R, Acharya C, Bindu P C, Kundu S C. Biochem. Mol. Biol. Rep. 2008; 41:236.
- Dash R, Mandal M, Ghosh S K, Kundu S C. Mol. Cell. Biochem. 2008; 311:111.
- Zhaorigetu S, Masahiro S, Watanabe H, Kato N. Biosci. Biotechnol. Biochem. 2001; 65:2181.
- Sasaki M, Yamada H, Kato N. Nutr. Res. 2000; 20:1505.
- Tamada Y, Sano M, Niwa K, Imai T, Yoshino G. J. Biomater. Sci. Polym. Ed. 2004; 15:971.
- Aramwit P, Kanokpanont S, De-Eknamkul W, Kamei K, Srichana T. J. Biomater. Sci. Polym. Ed. 2009; 20:1295.
- Zhang Y Q. Biotechnol. Adv. 2002; 20:91.
- Zhang Y Q, Ma Y, Xia Y Y, Shen W D, Mao J P, Xue R Y. J. Control. Release 2006; 115:307.
- Aramwit P, Kanokpanont S, De-Eknamkul W, Srichana T. J. Biosci. Bioengg. 2009; 107:556.
| Volume | 03 |
| Issue | 01 |
| Received | 10/02/2025 |
| Accepted | 12/02/2025 |
| Published | 15/02/2025 |
async function fetchCitationCount(doi) {
let apiUrl = `https://api.crossref.org/works/${doi}`;
try {
let response = await fetch(apiUrl);
let data = await response.json();
let citationCount = data.message[“is-referenced-by-count”];
document.getElementById(“citation-count”).innerText = `Citations: ${citationCount}`;
} catch (error) {
console.error(“Error fetching citation count:”, error);
document.getElementById(“citation-count”).innerText = “Citations: Data unavailable”;
}
}
fetchCitationCount(“10.37591/IJPPR.v03i01.0”);
