Botanical Blockade: Phytochemical Targeting Of Nf-Κb in Cancer Therapy

Year : 2025 | Volume : | : | Page : –
By
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Mohd. Wasiullah,

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Piyush Yadav,

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Girijesh Yadav,

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Pritam Kumar Yadav,

  1. Principal, Dept. of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India
  2. Professor &Head, Department of Pharmaceutical Chemistry, Prasad Institute of Technology, Uttar Pradesh, India
  3. Associate Professor, Dept. of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India
  4. Research Scholar, Dept. of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India

Abstract

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The control of inflammation, corpuscle survival, proliferation, and allowed response are all influenced by the acute archetypal agent NF-κB. Its abnormal activity is typically seen in a range of malignancies, where it aids in bump advancement, metastasis, and treatment waste. The function of NF-κB in scar analysis is discussed in this product, along with significant phytochemicals that seem to be interested in targeting this pathway, based on recent investigation. It also offers details on their workings, areas for improvement, and challenges with logical operation. The intricate signaling networks that play a part in the development and metastasis of cancer have long been the focus of oncology exploration. Among these pathways, nuclear factor- kappa B( NF- κB) is a crucial controller of inflammation, cell survival, and proliferation, making it a promising target for cancer remedy. In recent times, interest has concentrated on the capability of natural composites deduced from shops, known as phytochemicals, to modify NF- κB exertion. This composition explores the eventuality of phytochemicals to target NF- κB for cancer treatment, as well as their mechanisms of action, preclinical effectiveness, clinical uses, challenges, and possible unborn paths in the use of botanical substances to combat cancer.

Keywords: Cancer, NF-κB signaling pathway, Anti-cancer activity, Nrf2/NF-κB crosstalk, Botanical blockade.

How to cite this article:
Mohd. Wasiullah, Piyush Yadav, Girijesh Yadav, Pritam Kumar Yadav. Botanical Blockade: Phytochemical Targeting Of Nf-Κb in Cancer Therapy. Research & Reviews: A Journal of Pharmacognosy. 2025; ():-.
How to cite this URL:
Mohd. Wasiullah, Piyush Yadav, Girijesh Yadav, Pritam Kumar Yadav. Botanical Blockade: Phytochemical Targeting Of Nf-Κb in Cancer Therapy. Research & Reviews: A Journal of Pharmacognosy. 2025; ():-. Available from: https://journals.stmjournals.com/rrjopc/article=2025/view=0

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Ahead of Print Subscription Review Article
Volume
Received 14/12/2024
Accepted 04/01/2025
Published 15/01/2025
128