Nutraceuticals as Adjunctive Treatment in Cancer Exploring Efficacy and Mechanism of Action

Year : 2025 | Volume : | : | Page : –
By
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Mohd. Wasiullah,

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Piyush Yadav,

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Mohit Vishwakarma,

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Nitesh Maurya,

  1. Principal, Dept. of Pharmacy, Prasad Institute of Technology, Uttar Pradesh, India
  2. Professor & Head, Department of Pharmaceutical Chemistry, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India
  3. Assistant Professor, Dept. of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India
  4. Scholar, Dept. of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India

Abstract

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Dietary habits are a critical factor in cancer prevention, with plant-based diets rich in vegetables and fruits associated with reduced cancer risk. Nutraceuticals—bioactive compounds derived from food and supplements—have gained attention for their potential in cancer prevention and therapy. Phytochemicals such as flavonoids, polyphenols, and alkaloids exhibit anti-cancer properties through mechanisms including antioxidant activity, anti-inflammatory effects, inhibition of tumor growth, and induction of apoptosis. Key nutraceuticals include alkaloids (e.g., caffeine, taxol), polyphenols (e.g., curcumin, quercetin), and omega-3 fatty acids (e.g., DHA, EPA), all of which influence cancer cell signaling, DNA repair, and immune response. Additionally, traditional herbal remedies, such as those in Traditional Chinese Medicine (e.g., Yangzheng Xiaoji), and marine-derived compounds (e.g., Trabectedin, Kahalalide F) show promise in inhibiting cancer cell adhesion, inducing apoptosis, and blocking angiogenesis. These natural compounds, with their diverse mechanisms, present potential alternatives or adjuncts to conventional cancer treatments, offering a pathway to less toxic, more effective therapies.

Keywords: Cancer treatment, phenols, lignans, lipids, alkaloids, flavonoids

How to cite this article:
Mohd. Wasiullah, Piyush Yadav, Mohit Vishwakarma, Nitesh Maurya. Nutraceuticals as Adjunctive Treatment in Cancer Exploring Efficacy and Mechanism of Action. Research & Reviews: A Journal of Pharmacognosy. 2025; ():-.
How to cite this URL:
Mohd. Wasiullah, Piyush Yadav, Mohit Vishwakarma, Nitesh Maurya. Nutraceuticals as Adjunctive Treatment in Cancer Exploring Efficacy and Mechanism of Action. Research & Reviews: A Journal of Pharmacognosy. 2025; ():-. Available from: https://journals.stmjournals.com/rrjopc/article=2025/view=0

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References

 

  1. Smith-Warner, S. A., Elmer, P. J., Tharp, T. M., Fosdick, L., Randall, B., Gross, M. Potter, D. (2000).Increasing vegetable and fruit intake: randomized intervention and monitoring in an at-risk population. Cancer Epidemiol Biomarkers Prev, 9,(3) 307-317.
  2. Andersen, , Holst, R., & Vogel, U. (2013). Systematic review: diet-gene interactions and the risk ofcolorectal cancer. Aliment Pharmacol Ther, 37, 383-391. http://dx.doi.org/10.1111/apt.12180
  3. Pericleous, M., Mandair, D., & Caplin, M.E. (2013). Diet and supplements and their impact on colorectal cancer. J Gastrointest Oncol, 4, 409-423, doi: 3978/j.issn.2078-6891.2013.003
  4. Jemal, A., Bray, F., Center, M. M., Ferlay, J., Ward, E., & Forman, D. (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. http://dx.doi.org/10.3322/caac.20107
  5. Fernandes, G. (1989). The influence of diet and environment. Curr Opin Immunol, 2, 275-281.http://dx.doi.org/10.1016/0952-7915(89)90200-8
  6. Bazzan, A. J., Newberg, A. B., Cho, W. C., & Monti, D. (2013). Diet and Nutrition in Cancer Survivorship and Palliative Care. Evid Based Complement Alternat Med, 2013, 917647.http://dx.doi.org/10.1155/2013/917647
  7. Priyadarsini, R. V., & Nagini, S. (2012). Cancer chemoprevention by dietary phytochemicals: promises and pitfalls. Curr Pharm Biotechnol, 13,(1) 125-136. http://dx.doi.org/10.2174/138920112798868610
  8. Kalra, K. (2003). Nutraceutical – Definition and introduction. Aaps Pharmsci, 5(25). http://dx.doi.org/10.1208/ps050325
  9. Roudebush, , Davenport, D. J., & Novotny, B. J. (2004). The use of nutraceuticals in cancer therapy. Vet                Clin       N             Am-Small,                    34(1),         249-269. http://dx.doi.org/10.1016/j.cvsm.2003.09.001    
  1. Orzechowski, A., Ostaszewski, P., Jank, M., & Berwid, S. J. (2002). Bioactive substances of plant origin in food–impact on genomics. Reprod Nutr Dev, 42(5) , 461- http://dx.doi.org/10.1051/rnd:2002037
  2. Buckingham J, Baggaley KH, Roberts AD, Szabó LF (2010) Dictionary of alkaloids, 2nx edition. CRC Press, Taylor & Francis Group, Boca Raton,FL, USA. https://doi.org/10.1201/EBK1420077698
  3. Rais J, Jafri A, Siddiqui S, Tripathi M, Arshad M (2017) Phytochemicalsin the treatment of ovarian cancer. Front Biosci (Elite Ed) 9(1): 67-75. DOI: 10.2741/e786
  4. Cline JM, Hughes CL (1998) Phytochemicals for the prevention of breastand endometrial cancer. In Foon KA, Muss HB (eds), Biological andHormonal Therapies of Cancer, Kluwer Academic Publishers Boston,USA.
  5. Acharya A, Das I, Singh S, Saha T (2010) Chemopreventive properties ofindole-3- carbinol, diindolylmethane and other constituents of cardamomagainst carcinogensis. Recent Pat Food Nutr Agric Volume 2, Number 2, 2010, pp. 166-177(12)
  6. Arshad MS, Sohaib M, Nadeem M, Saeed F, Imran A, et (2017) Statusand trends of nutraceuticals from onion and onion by-products: A criticalreview. Cogent Food Agric 3: 1280254
  7. Zeng Y, Li Y, Yang J, Pu X, Du J, et al. (2017) Therapeutic role offunctional components in alliums for preventive chronic disease in human being. Evid Based Complement Alternat Med 2017(1): https://doi.org/10.1155/2017/9402849
  8. Varker KA, Ansel A, Aukerman G, Carson WE (2012) Review of complementary and alternative medicine and selected nutraceuticals: Background for a pilot study on nutrigenomic intervention in patientswith advanced Alternate Therapies Health Med, 18(2): 26-34.
  9. Sun, Y., Jia, X., Hou, L. et al.Involvement of apoptotic pathways in docosahexaenoic acid-induced benefit in prostate cancer: Pathway-focused gene expression analysis using RT2 Profile PCR Array System. Lipids Health Dis 16, 59 (2017). https://doi.org/10.1186/s12944-017-0442-5
  10. Yarnell E, Abascal K (2009) Plant coumarins: Myths and realities. Alternative and Complementary Therapies 15(1): 24-30 https://doi.org/10.1089/act.2009.15104
  11. Wang YH, Avula B, Nanayakkara NP, Zhao J, Khan IA (2013) Cassia cinnamon as a source of coumarin in cinnamon-flavored food and foodsupplements in the United States. J Agric Food Chem 61(18): 4470-4476.
  12. Morsy SA, Farahat AA, Nasr MNA, Tantawy AS (2017) Synthesis,molecular modeling and anticancer activity of new coumarin Saudi Pharm J In press. 2017 Sep 1;25 (6):873-83. https://doi.org/10.1016/j.jsps.2017.02.003    
  1. Dandriyal J, Singla R, Kumar M, Jaitak V (2016) Recent developments ofC-4 substituted coumarin derivatives as anticancer agents. Eur J MedChem 119: 141-168 https://doi.org/10.1016/j.ejmech.2016.03.087
  2. Kuete, V., Omosa, L.K., Tala, V.R.S. et al.Cytotoxicity of Plumbagin, Rapanone and 12 other naturally occurring Quinones from Kenyan Flora towards human carcinoma cells. BMC Pharmacol Toxicol 17, 60 (2016). https://doi.org/10.1186/s40360-016-0104-7
  3. Alam M, Khan A, Wadoo A, Khan A, Bashir S, et al. (2016) Bioassayguidedisolation of sesquiterpene coumarins from ferula narthex bioss: Anew anticancer agent. Front Pharmacol 7: 26. https://doi.org/10.3389/fphar.2016.00026
  4. Wang Z, Dabrosin C, Yin X, Fuster MM, Arreola A, et al. (2015) Broad targeting of angiogenesis for cancer prevention and therapy. Semin Cancer Biol: S224-S243. https://doi.org/10.1016/j.semcancer.2015.01.001
  5. Freyer G, You B, Villet S, Tartas S, Fournel-Federico C, et al. (2014) Openlabeluncontrolled pilot study to evaluate complementary therapy withRuta graveolens 9c in patients with advanced cancer. Homeopathy, 103:232-238.
  6. Henderson AJ, Ollila CA, Kumar A, Borresen EC, Raina K, et al. (2012)Chemopreventive properties of dietary rice bran: Current status andfuture prospects. Advanced Nutrition 3: 643-653.
  7. Aiyer HS, Warri AM, Woode DR, Hilakivi-Clarke L, Clarke R (2012)Influence of berry-polyphenols on receptor signaling and cell-deathpathways: Implications for breast cancer prevention. J Agric Food Chem60: 5693-5708.
  8. Goulas V, Stylos E, Chatziathanasiadou MV, Mavromoustakos T, TzakosA (2016) Functional components of carob fruit: Linking the chemical andbiological space. Int J Mol Sci 17: 1875.
  9. Sorrenti V, Vanella L, Acquaviva R, Cardile V, Giofrè S, et (2015)Cyanidin induces apoptosis and differentiation in prostate cancer cells.Int J Oncol 47: 1303- 1310.
  10. Raúl SC, Beatriz HC, Joseoziel LG, Francenia SSN (2017) Phenoliccompounds in genus Smilax (Sarsaparilla). In M Soto-Hernandez, MPalma-Tenango, M del Roasario Garcia-Mateos, Eds., Phenoliccompounds – Natural sources, importance and applications. Intech,Rijeka.
  11. Alzaharna M, Alqouqa I, Cheung HY (2017) Taxifolin synergizesAndrographolide- induced cell death by attenuation of autophagy andaugmentation of caspase dependent and independent cell death in HeLacells. PLoS One 12: e0171325.
  1. Yi L, Ma S, Ren D Phytochemistry and bioactivity of Citrusflavonoids: a focus on antioxidant, anti-inflammatory, anticancer andcardiovascular protection activities. Phytochem 16, 479–511 (2017). https://doi.org/10.1007/s11101-017-9497-1
  2. Li YR, Li S, Ho CT, Chang YH, Tan KT, et al. (2016) Tangeretin derivative, 5- acetyloxy-40-tetramethoxyflavone induces G2/M arrest,apoptosis and autophagy in human non-small cell lung cancer cells invitro and in vivo. Cancer Biol Ther 17: 48- 64 https://doi.org/10.1080/15384047.2015.1108491 .
  3. Hirano T, Abe K, Gotoh M, Oka K (1995) Citrus flavone tangeretininhibits leukaemic HL-60 cell growth partially through induction ofapoptosis with less cytotoxicity on normal lymphocytes. Br J Cancer 72:1380-1388.
  4. Morley KL, Ferguson PJ, Koropatnick J (2007) Tangeretin and nobiletininduce G1 cell cycle arrest but not apoptosis in human breast and coloncancer cells. Cancer Lett 251: 168-178.
  5. Amin ARM, Karpowicz PA, Carey TE, Arbiser J, Nahta R, et (2017)Evasion of anti- growth signaling: A key step in tumorigenesis andpotential target for treatment and prophylaxis by natural compounds.Semin Cancer Biol 35: S55-S77.
  6. Edwards V, Benkendorff K, Young F (2012) Marine compoundsselectively induce apoptosis in female reproductive cancer cells but not inprimary-derived human reproductive granulosa cells. Marine Drugs, 10:64-83.
  7. Boulton, S. (2012). “The role of DNA damage response in cancer treatment.” Cancer Therapy Review, 38(4): 360-368.
  8. Finn, R.S., et al. (2016). “Palbociclib and letrozole in advanced breast cancer.” The New England Journal of Medicine, 375(19): 1925-1936
  9. Ferrara, N., et al. (2004). “Bevacizumab (Avastin) in cancer treatment.” Nature Reviews Drug Discovery, 3(7): 467-481.
  10. Druker, J., et al. (2001). “Imatinib as a selective inhibitor of BCR-ABL.” Proceedings of the National Academy of Sciences, 98(11): 6947-6952.
  11. Topalian, S.L., et al. (2012). “Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.” The New England Journal of Medicine, 366(26): 2443-2454 DOI: 10.1056/NEJMoa1200690
  12. Tutt, A., et al. (2010). “Olaparib and single-agent chemotherapy in advanced breast cancer with a BRCA mutation.” New England Journal of Medicine, 363(7): 699-709.
  13. Jordan, M.A., and Wilson, L. (2004). “Microtubules as a target for anticancer drugs.” Nature Reviews Cancer, 4(4): 253-265.
  1. O’Shaughnessy, J., et al. (2015). “Trabectedin for the treatment of platinum-sensitive ovarian cancer.” Cancer Chemotherapy and Pharmacology, 75(5): 1075-1083.
Ahead of Print Subscription Review Article
Volume
Received 14/12/2024
Accepted 06/01/2025
Published 14/01/2025
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