Gastro Retentive Drug Target System: Its Needs, Advantages, Limitation and Approaches

Year : 2026 | Volume : 13 | 02 | Page :
    By

    Shyam Parbata,

  • Sneha Ghodkeb,

  • Pranjal Chougule,

  • Anuja Nirwane,

  • Nilesh Chougule,

  1. Student, Department of Pharmacy, Ashokrao Mane Institute of Pharmacy, Ambap, Kolhapur, Maharashtra, India
  2. Student, Department of Pharmacy, Ashokrao Mane Institute of Pharmacy, Ambap, Kolhapur, Maharashtra, India
  3. Assistant Professor, Department of Pharmacy, Ashokrao Mane Institute of Pharmacy, Ambap, Kolhapur, Maharashtra, India
  4. Assistant Professor, Department of Pharmacy, Ashokrao Mane Institute of Pharmacy, Ambap, Kolhapur, Maharashtra, India
  5. Principal, Ashokrao Mane Institute of Pharmacy, Ambap, Kolhapur, Maharashtra, India

Abstract

Background: Gastro retentive drug delivery systems (GRDDS) address limitations of oral therapy for drugs with poor solubility, instability at intestinal pH, or narrow absorption windows by prolonging gastric residence and increasing contact with the gastric mucosa. Objectives: To review GRDDS approaches—floating systems, mucoadhesive systems, and super porous hydrogels—with emphasis on formulation strategies and polymer–excipient selection to enhance gastric retention, modulate buoyancy/swelling/adhesion, and ultimately improve oral bioavailability and therapeutic outcomes for drugs with restricted absorption sites. Methods: Literature on GRDDS design and evaluation was examined, focusing on mechanisms (flotation, mucoadhesion, expansion, density based retention), classification of floating and non floating systems, critical polymer/excipient attributes that govern gelation, swelling and mucoadhesion, and typical in vitro and in vivo assessment methods including drug release kinetics, mucoadhesive strength, and gastric residence measurements. Results: GRDDS variants successfully prolonged gastric residence relative to conventional dosage forms and provided sustained release profiles that reduced dosing frequency and improved patient compliance; floating (effervescent and non effervescent), expanding, high density and bioadhesive systems each show distinct advantages and limitations depending on drug properties and physiological factors. Conclusions: GRDDS represent a versatile platform for enhancing bioavailability of drugs with narrow absorption windows or pH dependent stability, but translation requires optimization of polymer systems, improved in vitro–in vivo correlation, and consideration of scalability and safety for clinical use.

Keywords: Drug, Delivery system, Cell, Gut Microbiodata, Medical Research

How to cite this article:
Shyam Parbata, Sneha Ghodkeb, Pranjal Chougule, Anuja Nirwane, Nilesh Chougule. Gastro Retentive Drug Target System: Its Needs, Advantages, Limitation and Approaches. Trends in Drug Delivery. 2026; 13(02):-.
How to cite this URL:
Shyam Parbata, Sneha Ghodkeb, Pranjal Chougule, Anuja Nirwane, Nilesh Chougule. Gastro Retentive Drug Target System: Its Needs, Advantages, Limitation and Approaches. Trends in Drug Delivery. 2026; 13(02):-. Available from: https://journals.stmjournals.com/tdd/article=2026/view=248542


References

1. Kuldeep Vinchurkar, Jitendra Sainy, Masheer Ahmed Khan, Sheetal Mane, Dinesh K Mishra, Pankaj Dixit, “Features and Facts of a Gastro retentive Drug Delivery System-A Review” Turk J Pharm Sci, Jun 2021:19;4.
2. Meenakshi Jassal, Ujjwal Nautiyal, Jyotsana Kundlas, Devendra singh, “A review: Gastro retentive drug delivery system (grdds)” Indian Journal of Pharmaceutical and Biological Research (IJPBR), March 2015:3;1.
3. Sai Dividevara, K. Naveen Kumar, K. Preethi, “Gastro retentive drug delivery system: a review” International journal of research in pharmacy and chemistry April 2020:10;1.
4. Krishna, Abhishek Kumar, Rajat Srivastava, “In vitro in vivo studies on floating microspheres for gastro retentive drug delivery system: a review” Asian Journal of Pharmaceutical and Clinical Research, Nov 2020:14;1.
5. Nazia Khanam, Md Irshad Alam, S Shariq Mian, N Srinivas, “A Review on Novel Approaches Incorporated in The Formulation of Gastro Retentive Drug Delivery System” International Journal of Pharmacy and Biological Sciences, Jan 2017:7;1.
6. Guyton AC. Movement of food through the alimentary tract. In: Human Physiology and Mechanisms of Disease. Vol. 3. London: W.B. Saunders Co.; 1982. p. 487-97.
7. Shailaja Pant, Ashutosh Badola, Preeti Kothiyal, “A Review on Gastro retentive Drug Delivery System” International Journal of Research and Development in Pharmacy and Life Sciences, July 2016:5;4.
8. Garg AK, Kapoor G, Sachdeva RK. “Formulation and evaluation of nizatidine floating tablets” American Journal of pharmatech Research, Oct2012:2;5.
9. Kesarla RS, Vora PA, Sridhar BK, et al, “Formulation and evaluation of floating tablet of H2-receptor antagonist” Drug Dev Ind Pharm, April 2015:41;4
10. Kagan L, Hoffman, “Systems for region drug delivery in the gastrointestinal tract: biopharmaceutical considerations” Expert Opin Drug Deliv, Jun 2008:5;6.
11. Strubing S, Metz H, Mader K, “Characterization of poly (vinyl acetate) based floating matrix tablets” J Control Release, Sep 2008:126;2.
12. Khan F, Dehghan M, “Enhanced bioavailability of atorvastatin calcium from stabilized gastric resident formulation” AAPS Pharm Sci Tech, Dec 2011:12;4.
13. Oth, M., et al., “The bilayer floating capsule: a stomach-directed drug delivery system for misoprostol” Pharmaceutical research, Oct 1992:9;3.
14. Streubel A, Siepmann J, Bodmeier R, “Floating microparticles based on low density foam powder” International journal of pharmaceutics, Sep 2002:241;2.
15. Singh BN, Kim KH, “Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention” J. Control Release, Nov 2000:63;7
16. Deshpande AA, Shah NH, Rhodes CT, et al, “Controlled Release Drug Delivery Systems for prolonged gastric residence; An overview” Pharm. Res, Jun 1996:22;6.
17. Klausner EA, Lavy E, Friedman M, et al, “Novel levodopa gastro retentive dosage form: in-vivo evaluation in dogs” Journal of Controlled Release, Mar 2003:88;1.
18. Hoffman A, Stepensky D, “Pharmacodynamic aspects of modes of drug administration for optimization of drug therapy” Critical Reviews™ in Therapeutic Drug Carrier Systems, Aug 1999:16;6.
19. Smolensky MH, Peppas NA, “Chronobiology, drug delivery, and chronotherapeutics” Adv Drug Deliv Rev, Dec 2007:59;2.
20. Roy P, Shahiwala A, “Statistical optimization of ranitidine HCl floating pulsatile delivery system for chronotherapy of nocturnal acid breakthrough” Eur J Pharm Sci, April 2009:37;6.
21. Pawar VK, Kansal S, Asthana S, et al, “Industrial Perspective of Gastro retentive Drug Delivery System: Physiochemical, Biopharmaceutical, Technological and regulatory considerations” Expert opinion on drug delivery, Jun 2012:9;1.
22. Badoni A, Ojha A, Gnanarajani G, et al, “Review on Gastro Retentive Drug Delivery System” The Pharma Innovation, Feb 2012:1;8.
23. Novel drug delivery system- Y.W. Chien. Pg no. 1-42.
24. Wilson CG, Washington N, The Stomach: its role in the oral drug delivery. In: Rubinstein MH, ed, Physiological Pharmaceutical: biological barriers to drug absorption, chic ester, UK: EllisHorwood; 1989; 47Y70.
25. https://images.app.goo.gl/9vzecpbJkFRjcWj98.
26. Roop K khar, controlled drug delivery, gastro retentive system 4th edition, 202-203.
27. Khan F.N, Dehghan H.G, Int J Health Res, Mar 2009:2;1.
28. Kamalakkannan V, puratchikody A, Prasanth VV, masilamani K, “Enhancement of drugs bioavailabity by floating drug delivery system – A Review” international journal of drug delivery, Dec 2011:1;1.
29. Suryawanshi A, Hiremath SP, “floating drug delivery system- a review” American journal of pharmatech research, Aug 2011:2;1.
30. www.google.com.
31. Jain N.K, “Advances in Controlled & Novel Drug Delivery” CBS Publishers & Distributers, New Delhi, Pg-76-95.
32. Brahmankar D.M., “Biopharmaceutics and pharmacokinetics’’ vallabh prakashan, New Delhi, pg.335-370.
33. Narang N: an updated review on, “floating drug delivery system (FDDS)” International Journal of Applied pharmaceutics, Feb 2011:3;1.
34. Chandiran S, kumar BP, Nayaran V, “formulation an in vitro evaluation of floating drug delivery system for salbutamol sulphate” international journal of pharma biomed sciences, Apr 2010:1;1.
35. Jain A: new concept “floating drug delivery system” Indian journal of novel drug delivery, Jun 2011:3;3.
36. Geetha A, Rajendra K, Mohan CHK, Sateesh V, Raju PN, “A review on floating drug delivery systems” international journal of pharmaceutical research and biomedical analysis, Jan 2012:1;1.
37. https://images.app.goo.gl/4sAeZo6SPt8qSF9KA.
38. Devkant Sharma, Anjali Sharma, “Gastro retentive Drug Delivery System: A mini review” Asian pacific Journal of Health Sciences, Mar 2014:1;2.
39. Robinson J, Lee R, “Controlled Drug Delivery” 2nd edition ,1987: pg 418.
40. Bardonnet PL, Faivre V, Pugh WJ, Piffaretti JC, Falson F, “Gastro retentive Dosage Forms” Journal of Controlled Release, Aug 2006:1;18.
41. Arora S, Javed A, Ahuja A, Khar RK, Baboota S, “Floating Drug Delivery System: A Review” AAPS Pharm Sci Tech, Jun 2000:6;3.
42. Patel GM, Patel HR, Patel M, “Floating drug delivery system an innovative approach to prolong gastric retention” Pharmainfo.net, Oct 2007:4;1.

 

Ahead of Print Subscription Original Research
Volume 13
02
Received 29/05/2026
Accepted 29/06/2026
Published 01/07/2026
Publication Time 33 Days
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