Mannan-Rich Fractions in Poultry Nutrition: A Sustainable and Defensive Strategy against Antimicrobial Resistance

Year : 2026 | Volume : 03 | Issue : 02 | Page : 1 16
    By

    Jai Gopal Sharma,

  • Simran Kumari,

  • Priyanka Parmar,

  1. Professor, Department of Biotechnology, Delhi Technological University Shahbad Daulatpur, Delhi, New Delhi, India
  2. Student, Department of Biotechnology, Delhi Technological University Shahbad Daulatpur, Delhi, New Delhi, India
  3. Student, Department of Biotechnology, Delhi Technological University Shahbad Daulatpur, Delhi, New Delhi, India

Abstract

Antimicrobial resistance (AMR) has evolved to be a significant global threat, menacing worldwide health and food security. Its proliferation in poultry farming has spurred the search for sustainable, non-antibiotic alternatives. One promising alternative is Mannan-Rich Fractions (MRFs), which is derived from Saccharomyces cerevisiae. These bioactive compounds not only support poultry health but also aid in suppressing pathogenic bacteria without contributing to resistance. This review brings together current studies highlighting how MRFs exert heterogenous actions, including competitive exclusion of pathogens, encouraging beneficial gut microbes, immunomodulation, and metabolic disruption in resistant bacteria. Research indicates that MRFs effectively lowers the intestinal loads of Escherichia coli, Salmonella enterica, and Campylobacter jejuni etc. While improving feed conversion ratio, villus height, and nutrient absorption. At the molecular level, MRFs influences many key enzymes involved in glycolysis, TCA cycle and induce reactive oxygen species (ROS) production in resistant E. coli thereby resensitizing them to antibiotics. When used alongside fermented feed ingredients or probiotics, MRFs further enhance immune gene expression, growth rate, and gut barrier integrity. Together, these findings positions MRFs as a powerful, natural solution for minimizing antibiotic usage in poultry farming. The integration of MRFs into poultry diets presents a promising alternative to conventional antibiotic use, aligning with global effort to contain AMR in Poultry.

Keywords: Antimicrobial Resistance, Yeast Mannan Fraction, Poultry, Reactive Oxygen Species, Gut health.

[This article belongs to Recent Trends in Infectious Diseases ]

How to cite this article:
Jai Gopal Sharma, Simran Kumari, Priyanka Parmar. Mannan-Rich Fractions in Poultry Nutrition: A Sustainable and Defensive Strategy against Antimicrobial Resistance. Recent Trends in Infectious Diseases. 2026; 03(02):1-16.
How to cite this URL:
Jai Gopal Sharma, Simran Kumari, Priyanka Parmar. Mannan-Rich Fractions in Poultry Nutrition: A Sustainable and Defensive Strategy against Antimicrobial Resistance. Recent Trends in Infectious Diseases. 2026; 03(02):1-16. Available from: https://journals.stmjournals.com/rtid/article=2026/view=246537


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Regular Issue Subscription Review Article
Volume 03
Issue 02
Received 31/03/2026
Accepted 11/04/2026
Published 11/06/2026
Publication Time 72 Days
11

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