Functional Biomolecules in Animal Nutrition: Biochemical Mechanisms and Their Impacts on Growth Performance and Health Outcomes

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Year : 2026 | Volume : 3 | 02 | Page :
    By

    Md. Emran Hossain,

  1. Professor, Department of Animal Science and Nutrition, Chattogram Veterinary and Animal Sciences University, Khulshi, Chattogram, Bangladesh

Abstract

Functional biomolecules have emerged as critical modulators of animal nutrition, extending beyond conventional nutrient supply to regulate biochemical and physiological processes that determine growth performance and health outcomes. This review synthesizes current knowledge on diverse classes of bioactive compounds, including amino acids, peptides, fatty acids, vitamins, minerals, phytochemicals, and microbial-derived metabolites, and their roles in livestock systems. Emphasis is placed on underlying biochemical mechanisms such as enzyme activation, nutrient signaling pathways, gene expression modulation, and antioxidant defense systems. These biomolecules influence key metabolic pathways involved in protein synthesis, energy utilization, lipid metabolism, and immune function. Recent advances highlight the interaction between functional biomolecules and the gut microbiome, where microbial fermentation products and host microbe crosstalk contribute to improved nutrient digestibility, intestinal integrity, and disease resistance. Evidence demonstrates that strategic inclusion of functional biomolecules enhances feed efficiency, promotes muscle growth, supports reproductive performance, and mitigates metabolic and oxidative stress-related disorders. In addition, these compounds serve as effective alternatives to antibiotic growth promoters, aligning with global efforts toward sustainable and responsible livestock production. The integration of omics technologies, including metabolomics and proteomics, has further advanced the understanding of biomolecule-driven nutritional regulation, enabling precision feeding strategies tailored to species, production stage, and environmental conditions. However, challenges remain regarding bioavailability, dosage optimization, variability in responses, and economic feasibility. Future research should focus on mechanistic validation, the development of cost-effective delivery systems, and field-level applications. Overall, functional biomolecules represent a promising avenue for enhancing livestock productivity, health, and sustainability through targeted nutritional biochemistry.

Keywords: Animal health, bioactive compounds, feed efficiency, growth performance, metabolomics, nutritional biochemistry

How to cite this article:
Md. Emran Hossain. Functional Biomolecules in Animal Nutrition: Biochemical Mechanisms and Their Impacts on Growth Performance and Health Outcomes. International Journal of Nutritions. 2026; 03(02):-.
How to cite this URL:
Md. Emran Hossain. Functional Biomolecules in Animal Nutrition: Biochemical Mechanisms and Their Impacts on Growth Performance and Health Outcomes. International Journal of Nutritions. 2026; 03(02):-. Available from: https://journals.stmjournals.com/ijn/article=2026/view=245048


References

  1. I. A. Podolsky, S. Seppälä, T. S. Lankiewicz, J. L. Brown, C. L. Swift, and M. A.O’Malley, “Harnessing nature’s anaerobes for biotechnology and bioprocessing,”
    Annu. Rev. Chem. Biomol. Eng., vol. 10, pp. 105–128, 2019, doi: 10.1146/annurev-chembioeng-060718-030340.
  2. G. Sandner, M. Heckmann, and J. Weghuber, “Immunomodulatory activities of selected essential oils,” Biomolecules, vol. 10, no. 8, pp. 1–16, 2020, doi:
    10.3390/biom10081139.
  3. B. T. Nguyen et al., “Berberine Reveals Anticoccidial Activity by Influencing Immune Responses in Eimeria acervulina-Infected Chickens,” Biomolecules, vol. 15, no. 7, p. 985, Feb. 2025, doi: 10.3390/biom15070985.
  4. Z. Jiang et al., “Enzymatic regulation of the gut microbiota: mechanisms and implications for host health,” 2024, mdpi.com. [Online]. Available: https://www.mdpi.com/2218-273X/14/12/1638
  5. S. Girija, G. Kolluri, J. S. Tyagi, S. K. Kurva, and …, “Postbiotics: The Dynamic Biomolecules in Poultry Nutrition, Health, and Production,” Probiotics …, 2025, doi: 10.1007/s12602-025-10548-9.
  6. I. BenSouf et al., “Use of Natural Biomolecules in Animal Feed to Enhance Livestock Reproduction,” Int. J. Mol. Sci., vol. 26, no. 5, p. 2328, 2025, doi: 10.3390/ijms26052328.
  7. O. Kammona and C. Kiparissides, “Recent advances in nanocarrier-based mucosal delivery of biomolecules,” J. Control. Release, vol. 161, no. 3, pp. 781–794, 2012, doi: 10.1016/j.jconrel.2012.05.040.
  8. K. Pombo-García, O. Adame-Arana, C. Martin-Lemaitre, F. Jülicher, and A. Honigmann, “Membrane prewetting by condensates promotes tight-junction belt formation,” 2024, nature.com. doi: 10.1038/s41586-024-07726-0.
  9. N. Weiland-Bräuer, “Friends or foes—microbial interactions in nature,” 2021, mdpi.com. doi: 10.3390/biology10060496.
  10. P. Schröder and C. Collins, “Conjugating enzymes involved in xenobiotic metabolism of organic xenobiotics in plants,” Int. J. Phytoremediation, vol. 4, no. 4, pp. 247–265, 2002, doi: 10.1080/15226510208500086.
  11. M. Mujtaba et al., “Nanocarrier-Mediated Delivery of miRNA, RNAi, and CRISPR- Cas for Plant Protection: Current Trends and Future Directions,” ACS Agric. Sci. Technol., vol. 1, no. 5, pp. 417–435, 2021, doi: 10.1021/acsagscitech.1c00146.
  12. Y. Tian, J. Jennings, Y. Gong, and Y. Sang, “Viral infections and interferons in the development of obesity,” 2019, mdpi.com. [Online]. Available: https://www.mdpi.com/2218-273X/9/11/726
  13. M. Krawczyk, I. Burzynska-Pedziwiatr, L. A. Wozniak, and …, “Impact of polyphenols on inflammatory and oxidative stress factors in diabetes mellitus: nutritional antioxidants and their application in improving antidiabetic …,” 2023, mdpi.com. [Online]. Available: https://www.mdpi.com/2218-273X/13/9/1402
  14. C.-W. Wu and K. Storey, “mTOR Signaling in Metabolic Stress Adaptation,” Biomolecules, vol. 11, 2021, doi: 10.3390/biom11050681.
  15. W. Yang et al., “Correlation of the tight junction-like distribution of claudin-1 to the cellular tropism of hepatitis C virus,” 2008, jbc.org. doi: 10.1074/jbc.M709824200.
  16. Z. Yu et al., “Reactive Oxygen Species-Related Nanoparticle Toxicity in the Biomedical Field,” Nanoscale Res. Lett., vol. 15, no. 1, p. 115, 2020, doi: 10.1186/s11671-020-03344-7.
  17. A. A. Aljabali et al., “Nanomaterials and Their Impact on the Immune System,” Int. J. Mol. Sci., vol. 24, no. 3, p. 2008, 2023, doi: 10.3390/ijms24032008.
  18. K. Ghamkhar, S. Rochfort, B. K. Banik, and C. Revell, “Candidate metabolites for methane mitigation in the forage legume biserrula,” Agron. Sustain. Dev., vol. 38, no. 3, 2018, doi: 10.1007/s13593-018-0510-x.
  19. R. W. Li, “Rumen metagenomics,” Rumen Microbiol. From Evol. to Revolut., pp. 223–245, 2015, doi: 10.1007/978-81-322-2401-3_16.
  20. B. Binsila et al., “Review on transgenic technology in livestock: Current status and future horizons,” paas-pk.org, vol. 38, no. 12, pp. 3155–3173, Dec. 2021, doi: 10.1007/s10815-021-02334-7.
  21. S. S. Archana, S. Selvaraju, B. K. Binsila, A. Arangasamy, and S. A. Krawetz “Immune regulatory molecules as modifiers of semen and fertility: A review,” Mol. Reprod. Dev., vol. 86, no. 11, pp. 1485–1504, 2019, doi: 10.1002/mrd.23263.
  22. M. Kervella, F. Bertile, F. Bouillaud, and F. Criscuolo, “The cell origin of reactive oxygen species and its implication for evolutionary trade-offs,” Open Biol., vol. 15, no. 4, 2025, doi: 10.1098/rsob.240312.
  23. S. Debbarma, S. Deb, N. K. Yadav, S. Kashyap, and …, “Waste not, want not: unlocking the innovative potential of organic and eco-friendly insect and algal resources for future aquaculture,” Aquac. …, 2025, doi: 10.1007/s10499-024-01814-8.
  24. V. Batra, A. Kumaresan, R. Kumar, and T. K. Datta, “β-Defensins: Antimicrobial Peptides at the Intersection of Immunity and Male Fertility,” Curr. Concepts Bov. Reprod., pp. 293–317, 2022, doi: 10.1007/978-981-19-0116-4_15.
  25. A. Kumaresan, K. S. Praveen, A. Manimaran, and A. K. Srivastava, “Uterine Infection in Bovines: An Update,” Curr. Concepts Bov. Reprod., pp. 169–195, 2022, doi: 10.1007/978-981-19-0116-4_10.
  26. B. Poljšak and R. Fink, “The protective role of antioxidants in the defence against ROS/RNS-mediated environmental pollution,” Oxid. Med. Cell. Longev., vol. 2014, no. 1, p. 671539, 2014, doi: 10.1155/2014/671539.
  27. X. Cao, H. Lin, L. Muskhelishvili, J. Latendresse, P. Richter, and R. H. Heflich, “Tight junction disruption by cadmium in an in vitro human airway tissue model,” 2015, Springer. doi: 10.1186/s12931-015-0191-9.
  28. A. O. Oladejo et al., “Modulation of bovine endometrial cell receptors and signaling pathways as a nanotherapeutic exploration against dairy cow postpartum endometritis,” Animals, vol. 11, no. 6, p. 1516, 2021, doi: 10.3390/ani11061516.

Ahead of Print Subscription Original Research
Volume 03
02
Received 30/04/2026
Accepted 21/05/2026
Published 21/05/2026
Publication Time 21 Days


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