Rapid-On-Tongue Delivery: A Review of ODT Technologies, Taste Masking and Compliance

Year : 2026 | Volume : 13 | 01 | Page :
    By

    Himanshu Bisalpura,

  • Ankita Dubey,

  • Neha Sisodiya,

  • G.N. Darwhekar,

  1. Student, Department of Pharmaceutics, Acropolis Institute of Pharmaceutical Education and Research, Indore, Madhya Pradesh, India
  2. Associate Professor, Department of Pharmaceutics, Acropolis Institute of Pharmaceutical Education and Research, Indore, Madhya Pradesh, India
  3. Associate Professor, Department of Pharmaceutics, Acropolis Institute of Pharmaceutical Education and Research, Indore, Madhya Pradesh, India
  4. Principal, Department of Pharmacy, Acropolis Institute of Pharmaceutical Education and Research, Indore, Madhya Pradesh, India

Abstract

Orodispersible Tablets (ODTs), another name for Fast Dissolving Drug Delivery Systems (FDDS), are innovative drugs that dissolve in the mouth rapidly without requiring water. These will be especially helpful for kids, the elderly, and others who have difficulty swallowing ordinary tablets or capsules. Superdisintegrants are used in these pills to break down quickly in the mouth, while flavorings or sweeteners are used to cover up any harsh or unpleasant taste. Because they dissolve on the tongue, which accelerates the medication’s action, they offer comfort more rapidly. ODTs are commonly used to treat mental illnesses like depression or schizophrenia, cardiovascular conditions like high blood pressure, and acute symptoms like motion sickness or allergies. Most of these tablets are made by direct compression, which is a simple and affordable method, while additional methods like mold, freeze, or spray drying are also used. Since they are simple to take, act quickly, and don’t require water, they improve patient compliance, comfort, and safety. Due to ongoing research and development, MDDS are becoming increasingly important in modern, patient-focused healthcare systems.

Keywords: Rapid-on-Tongue Delivery, Drug Delivery, Fast-Dissolving Medication Delivery System, Fast Dissolving Tablets, Over-The-Counter (OTC) Medications.

How to cite this article:
Himanshu Bisalpura, Ankita Dubey, Neha Sisodiya, G.N. Darwhekar. Rapid-On-Tongue Delivery: A Review of ODT Technologies, Taste Masking and Compliance. Trends in Drug Delivery. 2025; 13(01):-.
How to cite this URL:
Himanshu Bisalpura, Ankita Dubey, Neha Sisodiya, G.N. Darwhekar. Rapid-On-Tongue Delivery: A Review of ODT Technologies, Taste Masking and Compliance. Trends in Drug Delivery. 2025; 13(01):-. Available from: https://journals.stmjournals.com/tdd/article=2025/view=232356


References

1. Bandari S, Mittapalli RK, Gannu R. Orodispersible tablets: An overview. Asian Journal of Pharmaceutics (AJP). 2008;2(1).
2. Jain P, Jain S, Mishra A. A Review on Orodispersible Tablet. Current Research in Pharmaceutical Sciences. 2014 Dec 26:99-109.
3. Garg A, Gupta MM. Mouth dissolving tablets: a review. Journal of Drug Delivery and Therapeutics. 2013;3(2):207-14.
4. Roshan K, Keerthy HS. Orodispersible tablets: a compendious review. Asian Journal of Pharmaceutical Research and Development. 2021 Jun 15;9(3):66-75.
5. Patil HK, Patil GM, Jain VH, Tadvi SA, Pawar SP. A review on mouth dissolving tablet. Journal of Applied Pharmaceutical Research. 2017 Apr 29;5(2):09-15.
6. Rahane RD, Rachh PR. A review on fast dissolving tablet. Journal of Drug Delivery and Therapeutics. 2018 Sep 6;8(5):50-5.
7. Iswariya, V. T. & Annamma Devi, G. S. A Review on Oral Disintegrating Tablets: A Boon in the World of Pharmaceuticals. International Journal of Research in Pharmacology & Pharmacotherapeutics. 2021 June 10(1): 97–106.
8. A., Sharma, A., & Vaghela, B. J. Formulation and Evaluation of Mouth Dissolving Tablets of Montelukast Sodium. Journal of Drug Discovery and Therapeutics. 2021 Feb 9(10).
9. Singh G, Dwivedi J, Govindasamy J, Kalra N, Sharma R. Formulation of Mouth dissolving tablets using solid dispersion technique: A Review. Indian Journal of Pharmaceutical and Biological Research. 2018 Sep 30;6(03):66-72.
10. Patel, M., & Patel, N. Electrospun Nanofibers in the Development of Mouth Dissolving Tablets. International Journal of Pharmaceutical Sciences and Research.2021 Aug 12(3): 1234-1242.
11. Reddy, M. S., & Reddy, P. S. Microneedle-Based Mouth Dissolving Tablets: A Revie w. Journal of Advanced Pharmaceutical Technology & Research.2022 13 Jan (1): 45-50.
12. Shaikh R, Deshmukh P. Mouth dissolving tablets: A review. Int J Pharm Sci Res. 2010;1(6):1-10.
13. Kumar P, Prakash A. Mouth dissolving tablets: A novel approach to drug delivery. J Pharm Res. 2014;8(6):786-92.
14. Patel D, Patel P. Mouth dissolving tablets: A review. Pharma Tutor. 2012;1(6):33-9.
15. Kumar S, Bhandari A. Formulation and evaluation of mouth dissolving tablets of anti-allergic drug. Asian J Pharm Clin Res. 2013;6(3):175-9.
16. Singh S, Sharma V. A review on mouth dissolving tablets. Int J Pharm Pharm Sci. 2011;3(2):29-32.
17. Patel H, Patel M. Mouth dissolving tablets: A review. Int J Pharm Sci Rev Res. 2015;31(2):22-6.
18. Yadav N, Sharma S. Superdisintegrants in the formulation of mouth dissolving tablets: A review. Indian J Pharm Educ Res. 2017;51(2):234-43.
19. Kamble P, Shinde P. Mouth dissolving tablets: A review. Int J Curr Pharm Res. 2016;8(2):12-9.
20. Gupta M, Gupta R. Development and evaluation of mouth dissolving tablets of Domperidone. J Pharm Sci Res. 2018;10(6):1511-6.
21. Bhattacharya S, Pal A. Mouth dissolving tablets: An overview. Indian J Pharm Sci. 2014;76(1):1-6.
22. Singh B, Singh R. Technologies for fast dissolving tablets: A review. Int J Pharm Sci Drug Res. 2015;7(3):144-52.
23. Joshi P, Patel D. Recent advances in mouth dissolving tablets: An overview. Pharma Innov. 2016;5(9):39-46.
24. Gupta A, Kumar S. Formulation and evaluation of mouth dissolving tablets using natural superdisintegrant. J Drug Deliv Ther. 2017;7(6):27-33.

Ahead of Print Subscription Review Article
Volume 13
01
Received 25/10/2025
Accepted 07/11/2025
Published 16/11/2025
Publication Time 22 Days
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