A Literature Survey on Biological Activities of Thiazolidine Derivatives

Year : 2025 | Volume : 03 | Issue : 02 | Page : 16 21
    By

    Vijaiyalakshmi R,

  • Anbazhagan S,

  • Subasri B,

  • Divya J,

  • Madeshwaran G,

  • Eniyan M,

  • Surya Prakash k,

  1. Assistant Professor, Department of Pharmacy, Surya School of Pharmacy, Surya Group of Institution, Vikravandi, Tamil Nadu, India
  2. Principal, Department of Pharmacy, Surya School of Pharmacy, Surya Group of Institution, Vikravandi, Tamil Nadu, India
  3. Project Student, Department of Pharmacy, Surya School of Pharmacy, Surya Group of Institution, Vikravandi, Tamil Nadu, India
  4. Project Student, Department of Pharmacy, Surya School of Pharmacy, Surya Group of Institution, Vikravandi, Tamil Nadu, India
  5. Project Student, Department of Pharmacy, Surya School of Pharmacy, Surya Group of Institution, Vikravandi, Tamil Nadu, India
  6. Project Student, Department of Pharmacy, Surya School of Pharmacy, Surya Group of Institution, Vikravandi, Tamil Nadu, India
  7. Project Student, Department of Pharmacy, Surya School of Pharmacy, Surya Group of Institution, Vikravandi, Tamil Nadu, India

Abstract

Hetercyclic compounds play a vital role in both chemical and life sciences. Among them ,thiazolidinone represent a significant class, characterized by a five- membered saturated ring containing both sulfur and nitrogen atoms. Structurally, thiazolidinones are derived from thiazole, with sulfur position at the 1-position, nitrogen at the 3-position , and a carbonyl group typically located at the 2-, 4-, or 5- position are possible, though structural and functional diversity is most stronghly influenced by the group attached at the 2-position carbon 4- Thiazolidinones , in particular , are derivatives of thiazolidine featuring a carbonyl group in thiazolidinones is generally unreactive , its interaction with Lawessons reagent can yeild corresponding 4-thione derivatives . The presence of hetero atom such as nitrogen , sulfur, and oxygen contribute to the broad biological activity many heterocyclic compounds.

Keywords: Antimicrobial drug, tuberculosis, thiazolidine, biological activities, hetercyclic compounds

[This article belongs to International Journal of Cheminformatics ]

How to cite this article:
Vijaiyalakshmi R, Anbazhagan S, Subasri B, Divya J, Madeshwaran G, Eniyan M, Surya Prakash k. A Literature Survey on Biological Activities of Thiazolidine Derivatives. International Journal of Cheminformatics. 2025; 03(02):16-21.
How to cite this URL:
Vijaiyalakshmi R, Anbazhagan S, Subasri B, Divya J, Madeshwaran G, Eniyan M, Surya Prakash k. A Literature Survey on Biological Activities of Thiazolidine Derivatives. International Journal of Cheminformatics. 2025; 03(02):16-21. Available from: https://journals.stmjournals.com/ijci/article=2025/view=229515


References

  1. Kapoor G, Pathak DP, Bhutani R, Kant R. Thiazolidinone as a pharmacologically active molecule. J Chem Pharm Res. 2016;8(4):151–68.
  2. Pandey Y, Singh A, Sharma PK, Kumar N. Biological activities of thiazolidine: a review. J Curr Pharm Res. 2011;1(2):192.
  3. Singh TP, Sharma PK, Kaur PK, Mondal SC, Gupta A. Pharmacological evaluation of thiazolidinone derivatives: a perspective review. Der Pharma Chem. 2011;3(1):194–206.
  4. Kanchumarthy SJ, Rasajna G, Kamala G, Nehitha P, Deepthi P, Madhavi K, Likitha G, Narendra P. Current advances in synthesis and therapeutic applications of thiazole and its derivatives. J Pharm Insights Res. 2024;2(6):107–14. doi:10.69613/4ph6pj28
  5. Mishra G, Jyoti K. Review on biological activities of 1,3,4-thiadiazole derivatives. J Appl Pharm Sci. 2011;1(7):44–9.
  6. Jain A, Sahu SK. Thiazolidine derivatives and their pharmacological actions. In: E3S Web Conf. 2024;556:01052. EDP Sciences. doi:10.1051/e3sconf/202455601052
  7. Kempegowda SK, Kumar DP, TT M. Thiadiazoles: progress report on biological activities. Der Pharma Chem. 2011;3(2):330–41.
  8. Pandey Y, Singh A, Sharma PK, Kumar N. Biological activities of thiazolidine: a review. J Curr Pharm Res. 2011;1(2):192.
  9. Jain AK, Vaidya A, Ravichandran V, Kashaw SK, Agrawal RK. Recent developments and biological activities of thiazolidinone derivatives: a review. Bioorg Med Chem. 2012;20(11):3378–95.
  10. Singh SP, Parmar SS, Raman K, Stenberg VI. Chemistry and biological activity of thiazolidinones. Chem Rev. 1981;81(2):175–203.[7]

Regular Issue Subscription Review Article
Volume 03
Issue 02
Received 09/09/2025
Accepted 08/10/2025
Published 20/10/2025
Publication Time 41 Days


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