Neuroprotective Effects of Curcuma longa: A Review of Its Role in Neurodegenerative Diseases

[{“box”:0,”content”:”n[if 992 equals=”Open Access”]n

n

n

n

Open Access

nn

n

n[/if 992]n[if 2704 equals=”Yes”]n

n

Notice

nThis is an unedited manuscript accepted for publication and provided as an Article in Press for early access at the author’s request. The article will undergo copyediting, typesetting, and galley proof review before final publication. Please be aware that errors may be identified during production that could affect the content. All legal disclaimers of the journal apply.n

n[/if 2704]n

n

Year : 2025 [if 2224 equals=””]05/10/2025 at 7:29 PM[/if 2224] | [if 1553 equals=””] Volume : 12 [else] Volume : 12[/if 1553] | [if 424 equals=”Regular Issue”]Issue : [/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] 03 | Page : 1 9

n

n

nn

n

n

n

    By

    n

    [foreach 286]n

    n

    Archana Kumari, Priya Sharma,

    n t

  • n

    n[/foreach]

    n

n[if 2099 not_equal=”Yes”]n

    [foreach 286] [if 1175 not_equal=””]n t

  1. Assistant Professor, Assistant Professor, Department of Pharmacy, School of Pharmacy and Emerging Sciences, Baddi University of Emerging Sciences & Technology, Baddi, Solan, Department of Pharmacy, School of Pharmacy and Emerging Sciences, Baddi University of Emerging Sciences & Technology, Baddi, Solan, Himachal Pradesh, Himachal Pradesh, India, India

    2. n[/if 1175][/foreach]

n[/if 2099][if 2099 equals=”Yes”][/if 2099]n

n

Abstract

n

Edit

n

nCurcuma longa (turmeric), a perennial herb notably utilized in traditional medication, has garnered big clinical attention due to its major bioactive compound, curcumin. Curcumin, well-known shows a couple of organic activities, together with antioxidant, anti-amyloidogenic, and neurodegenerative effects, making it a promising candidate for the management of neurodegenerative diseases (NDDs), which include Alzheimer’s illness, Parkinson’s disorder (PD), Huntington’s sickness (HD), and amyotrophic lateral sclerosis (ALS). This evaluate consolidates current findings at the neuroprotective mechanisms of curcumin, its pharmacokinetics, bioavailability demanding situations, and its utility in medical settings. Emphasis is laid on in vitro and in vivo studies, as well as scientific trials assisting the efficacy of curcumin in mitigating neurodegenerative pathologies. Advances in nano formulation techniques aimed at enhancing its mind-targeted shipping are also mentioned. Universal, curcumin emerges as a multifaceted neuroprotective agent with translational relevance within the prevention and treatment of NDDs.nn

n

n

n

Keywords: Curcuma longa, curcumin, neuroprotection, neurodegenerative diseases, Alzheimer’s disease, Parkinson’s disease.

n[if 424 equals=”Regular Issue”][This article belongs to Research & Reviews: A Journal of Pharmacognosy ]

n

[/if 424][if 424 equals=”Special Issue”][This article belongs to Special Issue under section in Research & Reviews: A Journal of Pharmacognosy (rrjopc)][/if 424][if 424 equals=”Conference”]This article belongs to Conference [/if 424]

n

n

n

How to cite this article:
nArchana Kumari, Priya Sharma. [if 2584 equals=”][226 wpautop=0 striphtml=1][else]Neuroprotective Effects of Curcuma longa: A Review of Its Role in Neurodegenerative Diseases[/if 2584]. Research & Reviews: A Journal of Pharmacognosy. 04/10/2025; 12(03):1-9.

n

How to cite this URL:
nArchana Kumari, Priya Sharma. [if 2584 equals=”][226 striphtml=1][else]Neuroprotective Effects of Curcuma longa: A Review of Its Role in Neurodegenerative Diseases[/if 2584]. Research & Reviews: A Journal of Pharmacognosy. 04/10/2025; 12(03):1-9. Available from: https://journals.stmjournals.com/rrjopc/article=04/10/2025/view=0

nn

n

n[if 992 equals=”Open Access”]Full Text PDF[/if 992]n

n

n[if 992 not_equal=”Open Access”]n

n

n[/if 992]n

nn

nnn

n[if 379 not_equal=””]nn

Browse Figures

n

n

n[foreach 379]

figures

[/foreach]n

n

n

n[/if 379]

n

n

Edit

n

n

n

References n

n[if 1104 equals=””]n

  1. Gupta A, Sharma B. Neurodegenerative diseases (ND): An introduction. In: Synaptic Plasticity in Neurodegenerative Disorders. CRC Press; 2025. pp. 3–20.
  2. Kaliyadasa E, Samarasinghe BA. A review on golden species of Zingiberaceae family around the world: Genus Curcuma. Afr J Agric Res. 2019;14(9):519–531. doi: 10.5897/AJAR2018.13755.
  3. Vo TS, Vo TT, Vo TT, Lai TN. Turmeric (Curcuma longa): Chemical components and their effective clinical applications. J Turk Chem Soc A Chem. 2021;8(3):883–898. doi: 10.18596/jotcsa.913136.
  4. Chanda S, Ramachandra TV. Phytochemical and pharmacological importance of turmeric (Curcuma longa): A review. Res Rev J Pharmacol. 2019;9(1):16–23.
  5. Fuloria S, Mehta J, Chandel A, Sekar M, Rani NN, Begum MY, et al. A comprehensive review on the therapeutic potential of Curcuma longa Linn. in relation to its major active constituent curcumin. Front Pharmacol. 2022;13:820806. doi: 10.3389/fphar.2022.820806.
  6. Helson L. Curcumin (diferuloylmethane) delivery methods: A review. Biofactors. 2013;39(1):21–26. doi: 10.1002/biof.1080.
  7. Jayaprakasha GK, Rao LJ, Sakariah KK. Antioxidant activities of curcumin, demethoxycurcumin and bisdemethoxycurcumin. J Agric Food Chem. 2002;50(13):3668–3672. doi: 10.1021/jf025506a.
  8. Orellana-Paucar AM. Turmeric essential oil constituents as potential drug candidates: A comprehensive overview of their individual bioactivities. Molecules. 2024;29(17):4210. doi: 10.3390/molecules29174210.
  9. Hooda P, Malik R, Bhatia S, Al-Harrasi A, Najmi A, Zoghebi K, et al. Phytoimmunomodulators: A review of natural modulators for complex immune system. Heliyon. 2024;10(1):e23790. doi: 10.1016/j.heliyon.2023.e23790.
  10. Nebrisi EE. Neuroprotective activities of curcumin in Parkinson’s disease: A review of the literature. Int J Mol Sci. 2021;22(20):11248. doi: 10.3390/ijms222011248.
  11. Islam MT. Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders. Neurol Res. 2017;39(1):73–82. doi: 10.1080/01616412.2016.1251711.
  12. Rauf A, Badoni H, Abu-Izneid T, Olatunde A, Rahman MM, Painuli S, et al. Neuroinflammatory markers: Key indicators in the pathology of neurodegenerative diseases. Molecules. 2022;27(10):3194. doi: 10.3390/molecules27103194.
  13. Candelise N, Scaricamazza S, Salvatori I, Ferri A, Valle C, Manganelli V, et al. Protein aggregation landscape in neurodegenerative diseases: Clinical relevance and future applications. Int J Mol Sci. 2021;22(11):6016. doi: 10.3390/ijms22116016.
  14. Bhat AH, Dar KB, Anees S, Zargar MA, Masood A, Sofi MA, et al. Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight. Biomed Pharmacother. 2015;74:101–110. doi: 10.1016/j.biopha.2015.07.025.
  15. Namgyal D, Ali S, Mehta R, Sarwat M. The neuroprotective effect of curcumin against Cd-induced neurotoxicity and hippocampal neurogenesis promotion through CREB-BDNF signaling pathway. Toxicology. 2020;442:152542. doi: 10.1016/j.tox.2020.152542.
  16. Bagheri H, Ghasemi F, Barreto GE, Rafiee R, Sathyapalan T, Sahebkar A. Effects of curcumin on mitochondria in neurodegenerative diseases. Biofactors. 2020;46(1):5–20.  doi: 10.1002/biof.1566.
  17. Sajjad R, Arif R, Shah AA, Manzoor I, Mustafa G. Pathogenesis of Alzheimer’s disease: Role of amyloid-beta and hyperphosphorylated tau protein. Indian J Pharm Sci. 2018;80(4):581–591. doi: 10.4172/pharmaceutical-sciences.1000397.
  18. Chaudhuri KR, Schapira AH. Non-motor symptoms of Parkinson’s disease: Dopaminergic pathophysiology and treatment. Lancet Neurol. 2009;8(5):464–474. doi: 10.1016/S1474-4422(09)70068-7.
  19. Podvin S, Reardon HT, Yin K, Mosier C, Hook V. Multiple clinical features of Huntington’s disease correlate with mutant HTT gene CAG repeat lengths and neurodegeneration. J Neurol. 2019;266:551–564. doi: 10.1007/s00415-018-8940-6.
  20. Chico L, Ienco EC, Bisordi C, Lo Gerfo A, Petrozzi L, Petrucci A, et al. Amyotrophic lateral sclerosis and oxidative stress: A double-blind therapeutic trial after curcumin supplementation. CNS Neurol Disord Drug Targets. 2018;17(10):767–779. doi: 10.2174/1871527317666180720162029.
  21. Liu W, Zhai Y, Heng X, Che FY, Chen W, Sun D, et al. Oral bioavailability of curcumin: Problems and advancements. J Drug Target. 2016;24(8):694–702. doi: 10.3109/1061186X.2016.1157883.
  22. Lee SH, Kim HY, Back SY, Han HK. Piperine-mediated drug interactions and formulation strategy for piperine: Recent advances and future perspectives. Expert Opin Drug Metab Toxicol. 2018;14(1):43–57. doi: 10.1080/17425255.2018.1418854.
  23. Sharma P, Mishra R, Sharma B, Kumari A, Modgil S. Health sciences: Advancing healthcare through interdisciplinary approaches and innovation. Int J Multidiscip Appl Bus Educ Res. 2025;6(5):2309–2316. doi: 10.11594/ijmaber.06.05.17.
  24. Mishra R, Verma A, Sharma B, Sharma P. An overview of transdermal patches: Opportunities and obstacles in modern drug delivery. Asian J Res Med Pharm Sci. 2025;14(3):18–29. doi: 10.9734/ajrimps/2025/v14i3314.
  25. Sharma P, Dhiman S, Sharma B, Mishra R. Liver cirrhosis: Current insights and emerging therapies.
  26. Mishra R, Sharma MP. Drug discovery to personalized care: The role of AI in revolutionizing healthcare. In: The Impact of Artificial Intelligence in Healthcare Management. p. 27.
  27. Yadav A, Sharma S, Wani SN, Kaushal K, Sharma P. Development of oral herbal male contraceptive. Curr Asp Pharm Res Dev. 2022;8:77–88. doi: 10.9734/bpi/caprd/v8/3416E.

nn[/if 1104][if 1104 not_equal=””]n

    [foreach 1102]n t

  1. [if 1106 equals=””], [/if 1106][if 1106 not_equal=””],[/if 1106]

    2. n[/foreach]

n[/if 1104]

n

nn[if 1114 equals=”Yes”]n

n[/if 1114]

n

n

[if 424 not_equal=””]Regular Issue[else]Published[/if 424] Subscription Review Article

n

n

[if 2146 equals=”Yes”][/if 2146][if 2146 not_equal=”Yes”][/if 2146]n

n

n

n

n

n

n

n

n

n

n

n

n

n

n

n

n

n

n

n

n[if 1748 not_equal=””]

[else]

[/if 1748]n

n[if 1746 equals=”Retracted”]n

n

n

n

[/if 1746]n[if 4734 not_equal=””]

n

n

n

[/if 4734]n

n

Volume 12
[if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] 03
Received 08/07/2025
Accepted 30/07/2025
Published 04/10/2025
Retracted
Publication Time 88 Days

n

n

114

nn

n

Login

n
My IP
n

PlumX Metrics

nn

n

n

n[if 1746 equals=”Retracted”]n

[/if 1746]nnn

nnn”}]