Pharmacokinetic and Pharmacodynamic Studies of Black Seed Derived Compound

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Year : 2025 | Volume :15 | Issue : 01 | Page : –
    By

    Mohd. Wasiullah,

  • Piyush Yadav,

  • Pooja Yadav,

  • Neha Kumari,

  1. Principal, Department of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India
  2. Academic Head, Department of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India
  3. Assistant Professor, Department of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India
  4. Scholar, Department of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India

Abstract

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Black seed (Nigella sativa) has been celebrated for centuries for its remarkable therapeutic properties. Among its bioactive compounds, thymoquinone (TQ) has gained significant attention in pharmacological research due to its diverse health benefits. This review delves into the pharmacokinetic (PK) and pharmacodynamic (PD) properties of black seed compounds, with a particular emphasis on TQ, the most extensively studied component. The pharmacokinetics of TQ include the parameters of absorption, distribution, metabolism, and excretion (ADME), which determine how the compound behaves within the body. Understanding these factors is crucial to optimizing its therapeutic potential. On the pharmacodynamic front, TQ exhibits mechanisms of action such as antioxidant, anti-inflammatory, and anti-cancer effects, making it a promising candidate for drug development.Additionally, clinical studies on black seed derivatives have shown encouraging results in managing various diseases, including inflammation, diabetes, cardiovascular disorders, and cancer. These findings highlight the immense potential of black seed compounds in modern medicine. By exploring the therapeutic benefits and mechanisms of action of TQ and other bioactives, this review aims to provide a comprehensive understanding of black seed’s role in promoting health and combating disease, paving the way for its integration into clinical applications.

Keywords: Nigella sativa, Bioavailability, Anti-inflammatory, Antioxidant, black seed

[This article belongs to Research & Reviews : A Journal of Biotechnology (rrjobt)]

How to cite this article:
Mohd. Wasiullah, Piyush Yadav, Pooja Yadav, Neha Kumari. Pharmacokinetic and Pharmacodynamic Studies of Black Seed Derived Compound. Research & Reviews : A Journal of Biotechnology. 2025; 15(01):-.
How to cite this URL:
Mohd. Wasiullah, Piyush Yadav, Pooja Yadav, Neha Kumari. Pharmacokinetic and Pharmacodynamic Studies of Black Seed Derived Compound. Research & Reviews : A Journal of Biotechnology. 2025; 15(01):-. Available from: https://journals.stmjournals.com/rrjobt/article=2025/view=0

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References

1. Zakarial Ansar FH, Latifah SY, Wan Kamal WHB, Khong KC, Ng Y, Foong JN, Gopalsamy B, Ng WK, How CW, Ong YS, Abdullah R, Aziz MY. Pharmacokinetics and Biodistribution of Thymoquinone-loaded Nanostructured Lipid Carrier After Oral and Intravenous Administration into Rats. Int J Nanomedicine. 2020 Oct 9;15:7703-7717. doi: 10.2147/IJN
2. Ahmad A, Khan RM, Alkharfy KM, Raish M, Al-Jenoobi FI, Al-Mohizea AM. Effects of Thymoquinone on the Pharmacokinetics and Pharmacodynamics of Glibenclamide in a Rat Model. Nat Prod Commun. 2015 Aug;10(8):1395-8
3. Ashrafizadeh M, Zarrabi A, Hashemi F, Zabolian A, Saleki H, Bagherian M, Azami N, Bejandi AK, Hushmandi K, Ang HL, Makvandi P. Polychemotherapy with curcumin and doxorubicin via biological nanoplatforms: enhancing antitumor activity. Pharmaceutics. 2020 Nov;12(11):1084.
4. Kanter M, Demir H, Karakaya M, Özbek H. The elimination and pharmacokinetics of thymoquinone in rats. J Ethnopharmacol. 2012;141(2):700-5.
5. El Gazzar MA. Thymoquinone suppressses in vitro production of IL-5 and IL-13 by mast cells in response to lipopolysaccharide stimulation. Inflamm Res. 2007 Aug;56(8):345-51. doi: 10.1007/s00011-007-7051-0.
6. Asaduzzaman Khan M, Tania M, Fu S, Fu J. Thymoquinone, as an anticancer molecule: from basic research to clinical investigation. Oncotarget. 2017 Apr 18;8(31):51907-51919. doi: 10.18632
7. Farkhondeh T, Samarghandian S, Shahri AMP, Samini F. The Neuroprotective Effects of Thymoquinone: A Review. Dose Response. 2018 Apr 11;16(2):1559325818761455. doi: 10.1177/1559325818761455
8. Kouidhi, B., Zmantar, T., Jrah, H. et al. Antibacterial and resistance-modifying activities of thymoquinone against oral pathogens. Ann Clin Microbiol Antimicrob 10, 29 (2011). https://doi.org/10.1186/1476-0711-10-29
9. Pal RR, Rajpal V, Singh P, Saraf SA. Recent Findings on Thymoquinone and Its Applications as a Nanocarrier for the Treatment of Cancer and Rheumatoid Arthritis. Pharmaceutics. 2021 May 22;13(6):775. doi: 10.3390/pharmaceutics13060775
10. Pal RR, Rajpal V, Singh P, Saraf SA. Recent Findings on Thymoquinone and Its Applications as a Nanocarrier for the Treatment of Cancer and Rheumatoid Arthritis. Pharmaceutics. 2021 May 22;13(6):775. doi: 10.3390/pharmaceutics13060775
11. Abd El-Hack ME, Alagawany M, Farag MR, Tiwari R, Karthik K, Dhama K. Nutritional, healthical and therapeutic efficacy of black cumin (Nigella sativa) in animals, poultry and humans. Int. J. Pharmacol. 2016 Jan 1;12(3):232-48.
12. Shahrajabian MH, Sun W. Importance of thymoquinone, sulforaphane, phloretin, and epigallocatechin and their health benefits. Letters in Drug Design & Discovery. 2024 Feb 1;21(2):209-25.
13. Iqbal S, Javeed A, Sattar A, Tanvir R. Pharmacokinetics of thymoquinone in layer chickens following oral and intravenous administration. J Vet Pharmacol Ther. 2019 Nov;42(6):707-712. doi: 10.1111/jvp.12810.
14. Taysi S, Algburi FS, Mohammed ZR, Ali OA, Taysi ME. Thymoquinone: a review on its pharmacological importance, and its association with oxidative stress, COVID-19, and radiotherapy. Mini Reviews in Medicinal Chemistry. 2022 Aug 1;22(14):1847-75.
15. Ali BH, Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytother Res. 2003 Apr;17(4):299-305. doi: 10.1002/ptr.1309. PMID: 12722128.
16. Lin CH, Hsieh CL. Chinese herbal medicine for treating epilepsy. Frontiers in Neuroscience. 2021 Jul 2;15:682821.
17. Kurowska N, Madej M, Strzalka-Mrozik B. Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer. Current Issues in Molecular Biology. 2023 Dec 23;46(1):121-39.
18. Kurowska N, Madej M, Strzalka-Mrozik B. Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer. Current Issues in Molecular Biology. 2023 Dec 23;46(1):121-39.
19. Alhmied F, Alammar A, Alsultan B, Alshehri M, Pottoo FH. Molecular mechanisms of thymoquinone as anticancer agent. Combinatorial Chemistry & High Throughput Screening. 2021 Nov 1;24(10):1644-53.
20. Tabassum S, Rosli N, Ichwan SJ, Mishra P. Thymoquinone and its pharmacological perspective: A review. Pharmacological Research-Modern Chinese Medicine. 2021 Dec 1;1:100020.
21. Adinew GM, Messeha SS, Taka E, Badisa RB, Soliman KFA. Anticancer Effects of Thymoquinone through the Antioxidant Activity, Upregulation of Nrf2, and Downregulation of PD-L1 in Triple-Negative Breast Cancer Cells. Nutrients. 2022 Nov 13;14(22):4787. doi: 10.3390/nu14224787.
22. Kokoska L, Havlik J, Valterova I, Sovova H, Sajfrtova M, Jankovska I. Comparison of chemical composition and antibacterial activity of Nigella sativa seed essential oils obtained by different extraction methods. J Food Prot. 2008 Dec;71(12):2475-80. doi: 10.4315/0362-028x-71.12.2475
23. Harzallah HJ, Grayaa R, Kharoubi W, Maaloul A, Hammami M, Mahjoub T. Thymoquinone, the Nigella sativa bioactive compound, prevents circulatory oxidative stress caused by 1,2-dimethylhydrazine in erythrocyte during colon postinitiation carcinogenesis. Oxid Med Cell Longev. 2012;2012:854065. doi: 10.1155/2012/854065.
24. Akram Khan M, Afzal M. Chemical composition of Nigella sativa Linn: part 2 recent advances. Inflammopharmacology. 2016 Jun;24:67-79.
25. Khader M, Eckl PM. Thymoquinone: an emerging natural drug with a wide range of medical applications. Iran J Basic Med Sci. 2014 Dec;17(12):950-7
26. Banerjee S, Padhye S, Azmi A, Wang Z, Philip PA, Kucuk O, Sarkar FH, Mohammad RM. Review on molecular and therapeutic potential of thymoquinone in cancer. Nutr Cancer. 2010;62(7):938-46.
27. Isaev NK, Chetverikov NS, Stelmashook EV, Genrikhs EE, Khaspekov LG, Illarioshkin SN. Thymoquinone as a Potential Neuroprotector in Acute and Chronic Forms of Cerebral Pathology. Biochemistry (Mosc). 2020 Feb;85(2):167-176.

Regular Issue Subscription Review Article
Volume 15
Issue 01
Received 14/12/2024
Accepted 11/01/2025
Published 01/02/2025
274