Payal Rani,
Manish Goyal,
Mandeep Kaur,
Amit Chawla,
Mangilal,
Vikramjit singh,
Ankit Gupta,
- Associate Professor, Seth GL Bihani SD college of Tech. Edu. Sri ganganagar, Rajasthan, India
- Research scholar, Maa Saraswati Institute of Pharmaceutical Sciences, Sitto Road, Abohar, Punjab, India
- Associate Professor, Maa Saraswati Institute of Pharmaceutical Sciences, Sitto Road, Abohar, Punjab, India
- Professor-Principal, Maa Saraswati Institute of Pharmaceutical Sciences, Sitto Road, Abohar, Punjab, India
- Assistant Professor, Maa Saraswati Institute of Pharmaceutical Sciences, Sitto Road, Abohar, Punjab, India
- Research scholar, MaaSaraswati Institute of Pharmaceutical Sciences, Sitto Road, Abohar, Punjab, India
- Assistant Professor, Seth GL Bihani SD college of Tech. Edu. Sri ganganagar, Rajasthan, India
Abstract
Papaya (Carica papaya Linn.) is a popular fruit tree in the tropical part of the world. It is a delicious, sweet fruit with a pleasant aroma. The papaya is consumed worldwide as a fresh fruit and vegetable. which is healthy for humans because all parts of the plant, including fruit, stem, bark, peel, fruit, seeds, and pulp, have medicinal properties. Papaya also has nutritional value and is also used as supplements because they contain various type of vitamins like vitamin A, B and C. The richest producers of Carica papaya are India and Brazil, which produce 50% of the whole production around the world. It also contains enzymes, such as papain and chymopapain that show various pharmacological activity, such as antifungal, antibacterial, anti-inflammatory, anti-helminthic, anti-allergic, ulcer protective, and some other activities. Both the ripe and green papaya have nutritional as well as medicinal values, which are used for the treatment of numerous health issues and to control them. As an anti-hypertensive drug, green papaya fruit is used to overcome the mean arterial blood pressure, whereas quercetin is used as an antioxidant. The aqueous extract is helpful for wound contraction and is anti-amoebic and antimalarial. It is used to treat hepatotoxicity, and the extract is valuable as a diuretic. The enzymes belong to the papaya family and are used as anti-inflammatory, along with antifungal agents. The crude extract has histaminergic properties, while the extract of bark is used as an anti-fertility compound. The latex of the papaya plant is used as a hepatotoxic product. The extract of the seed is used as an immunomodulatory agent.
Keywords: Papain, Carica papaya, Nutritional value, Medicinal value, Chymopapain.
[This article belongs to Research & Reviews: A Journal of Pharmacognosy ]
Payal Rani, Manish Goyal, Mandeep Kaur, Amit Chawla, Mangilal, Vikramjit singh, Ankit Gupta. Carica papaya Linn.: A review on Nutritional and Medicinal Value of Papaya. Research & Reviews: A Journal of Pharmacognosy. 2025; 12(01):67-75.
Payal Rani, Manish Goyal, Mandeep Kaur, Amit Chawla, Mangilal, Vikramjit singh, Ankit Gupta. Carica papaya Linn.: A review on Nutritional and Medicinal Value of Papaya. Research & Reviews: A Journal of Pharmacognosy. 2025; 12(01):67-75. Available from: https://journals.stmjournals.com/rrjopc/article=2025/view=196020
References
- Jiao, J. Deng, Gongke Li, Z. Zhang, Z. Cai, Study on the compositional differences between transgenic and non-transgenic papaya (Carica papaya L.), J. Food Comp. Anal. 23(6) (2010) 640-647 https://doi.org/10.1016/j.jfca.2010.03.004 .
- https://www.atlasbig.com/en-in/countries-by-papaya-production (accessed 28 october 2023)
- Aravind, B. Debjit, S. Duraivel, G. Harish, Traditional and medicinal uses of Carica papaya, J. Med. Plants Stud. 1(1) (2013) 7-15.
- Tarun Vij, Yash Prashar, A review on medicinal properties of Caricapapaya Linn, Asian Pac. J. Trop. Dis. 5(1) (2015) 1-6.
- Archbold, R. Koslanund, KW. Pomper, Ripening and post-harvest storage of pawpaw, Hort. Technology. 13 (2003) 439-441.
- Bari, P. Hasa, N. Absar, ME. Haque, MIIF. Khuda, MM. Pervin, S. Khatun and MI. Hussain, Nutritional analysis of two local varieties of papaya (Carica papaya L.) at different maturity stages, Pak. J. Bio. Sci. 9 (2006) 137-140.
- https://en.m.wikipedia.org/wiki/Papaya (accessed 28 october 2023)
- Bruneton Jean, Carica papaya In: Pharmacognosy, Phytochemistry of medicinal plants, Techniques and Documentation, France. 2 (1999) 221-223.
- Parker, ST. Esgro, SA. Miller, LE. Myers, RA. Meister, SA. Toshkov, NJ. Engeseth, Development of an optimised papaya pulp nectar using a combination of irradiation and mild heat, Food. Chem. 118 (2010) 861-869.
- Krishna, M. Paridhavi, Jagruti A. Patel, Review on nutritional, medicinal and pharmacological properties of papaya (Carica papaya Linn.), Nat. pro. Rad. 7(4) (2008) 364-373.
- Franke, M. Suzanne, R. Lacey, LJ. Custer, Tocopherol and tocotrienol levels of foods consumed in Hawaii, J. Agric. Food. Chem. 55(3) (2007) 769-778.
- Vijay Yogiraj, Pradeep kumar goyal, Chetan singh chauhan, Anju Goyal, Bhupendra Vyas, Carica papaya Linn: An Overview, Int. j. of herb. Med. 2(5) (2014) 01-08.
- https://www.britannica.com/plant/papaya (accessed 29 october 2023)
- Skelton, Q. Yu, R. Srinivasan, R. Manshardt, PH. Moore, R. Ming, Tissue differential expression of lycopene beta-cyclase gene in papaya, Cell. Res. 16 (2006) 731-739.
- Arya Vaidya Sala, Carica papaya, In: Indian medicinal plants & Compendium of 500 Species, Ori. Longman Pvt. Ltd. Hyderabad. 1 (2005) 383-384.
- Eno, OI. Owo, EH. Itam, RS. Konya, Blood pressure depression by the fruit juice of Carica papaya (L.) in renal and DOCA-induced hypertension in the rat, Phyto. Res. 14(4) (2000) 235-239.
- Oloyede, Chemical profile of unripe pulp of Carica Papaya, Park. J. Nutr. 4(6) (2005) 379-381.
- Nayak, L. Pereira Pinto, D. Maharh, Wound healing activity of Carica papaya L. In experimentally induced diabetic rats, Ind. J Exp. Biol. 45(8) (2007) 739-743.
- Rajkapoor, B. Jayakar, S. Kavimani and N. Murugesh, Effect of dried fruits of Carica papaya Linn. On hepatotoxicity, Biol. Pharm. Bull. 25(12) (2002) 1645-1646.
- Sadeque, ZA. Begum, Protective effect of dried fruits of Carica papaya on hepatotoxicity in rats, Bangladesh J. Pharmacol. 5(1) (2010) 48-50.
- Anibijuwn, AO. Udeze, Antimicrobial activity of Carica papaya (pawpaw leaf) on some pathogenic organisms of clinical origin from South-Western Nigeria.
- Calzada, L. Yepez-Mulia and A. Tapia-Contreras, Effect of Mexican medicinal plant used to treat trichomoniasis on Trichomonas vaginalis trophozoites, J. Ethno Pharmacol. 113(2) (2007) 248-251.
- Osato, LA. Santiago, GM. Remo, MS. Cuadra and A. Mori, Antimicrobial and antioxidant activities of unripe papaya, Life. Sci. 53(17) (1993) 1383-1389.
- Leite, RM. Nardi, JR. Nicoli, E. Chartone-Souza and AM. Nascimento, Carica papaya seed macerate as inhibitor of conjugative R plasmid transfer from Salmonella typhimurium to Escherichia coli, in vitro and in the digestive tract of genetobiotic mice, J. Gen. Appl. Microbiol. 51(1) (2005) 21-26.
- Pattison, AJ. Silman, NJ. Goodson, M. Lunt, D. Bunn, R. Luben, A. Welch, R. Bingham, Inflammatory polynuritis: Prospected nested case-control study, Ann. Rheum. Dis. 63 (2004) 843-847.
- Giordani, ML. Cardenas, J. Moulin-Traffort and P. Regli, Fungicidal activity of latex sap from Carica papaya and antifungal effect of D (+)-gucosamine on Candida albicans growth, Mycoses. 39(3-4) (1996) 103-110.
- Giordani, M. Siepaio, J. Moulin-Traffort and P. Regli, Antifungal action of Carica papaya latex, isolation of fungal cell wall hydrolyzing enzymes, Mycoses. 34(11-12) (1991) 469-477.
- Adebiyi, PG. Adaikan and RNV. Prasad, Histaminergic effect of crude papaya latex on isolated guinea pig ileal strips, Phytomedicine. 11(1) (2004) 65-70.
- Kusemiju, C. Noronha, A. Okanlawon, The effect of crude extract of the bark of Carica papaya on the seminiferous tubules of the male Sprague-Dawley rats, Niger. Postgrad. Med. J. 9(4) (2002) 205-209.
- Sripanidkulchai, V. Wongpanich, P. Laupattarakasem, J. Suwansaksri, D. Jirakulsomchok, Diuretic effects of selected Thia indigenous medicinal plants in rats, J.Ethnopharmacol. 75(2-3) (2001) 185-190.
- Tona, K. kambu, N. Ngimbi, K. Cimanga, AJ. Vlietinck, Antiamoebic and phytochemical screening of some Congolese medicinal plants, J. Ethnopharmacol. 61(1) (1998) 57-65.
- Satrija, P. Nansen, S. Murtini, S. He, Anthelimintic activity of papaya latex against Heligmosomoidespolygyrus infections in mice, J. Ethnopharmacol. 48(3) (1995) 161-164.
- Otsuki, NH. Dang, E. Kumagai, A. Kondo, S. Iwata, C. Morimoto, Aqueous extract of Carica papaya leaves exhibits anti tumor and immunomodulatory effects, J. Ethanopharmacol. 127(3) (2010) 760-767.
- Adebivi, PG. Adaikan, Modulation of jejuna contraction by extract of Carica papaya L. Seeds, Phytother. Res. 19(7) (2005) 628-632.
- Bhat, N. Surolia, In vitro anti-malarial activity of extracts of the three plants used in the traditional medicine of india, Am. J. Trop. Hyg. 65(4) (2001) 304-308.
- Mojica-Henshaw, AD. Francisco, F. Guzman De, XT. Tigno, Possible immunomodulatory actions of Carica papaya seed extract, Clin. Hemorheol. Microcirc. 29(3-4) (2003) 219-229.
- Fekeye, T. Oladipupo, O. Showande, Y. Ogunremi, Effects of co-administration of extract of Carica papaya on activity of two oral hypoglycaemic agents, Trop. J. Pharm. Res. 6(1) (2007) 671-678.
- Imaga, GO. Gbenle, VI. Okochi, SO. Akanbi, SO. Edeoghon, V. Oigbochie, Antisickling property of Carica papaya leaf extract, Afr. J. Biochem. Res. 3(4) (2009) 102-106.
- Tolunigba, WO. Adekunle, Gastroprotective activity of aqueous Carica papaya seed extract on ethanol induced gastric ulcer in male rats, Afr. J. Biotechnol. 11(34) (2012) 8612-8615.

Research & Reviews: A Journal of Pharmacognosy
| Volume | 12 |
| Issue | 01 |
| Received | 17/01/2025 |
| Accepted | 23/01/2025 |
| Published | 30/01/2025 |
| Publication Time | 13 Days |
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