Stilbenes: An emerging resource for Scavenging Reactive Oxygen Species in the field of Colon Malignancy. A molecular docking and ADMET Analysis approach.

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Year : 2024 | Volume :14 | Issue : 03 | Page : –
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Aayushi Chaudhuri,

  1. Student, School of Bio Sciences and Technology, Vellore Institute of Technology, Tamil Nadu, India

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Objective: Colon malignancy also referred as colon cancer, originates as precancerous polyps in colon or rectum, which has the potential to thrive and progress into cancerous tumors over time. This study delves into various bioactive compounds (from natural sources like plants) to assess their potential efficacy in inhibiting colon malignancy, as compared to conventional methods. Methods: The objective of this study was to employ computational methodologies to evaluate the efficacy of various stilbenes against TRAF2, a protein associated with colon cancer. Molecular docking was systematically conducted using the virtual screening tool PyRx. Among the screened natural compounds, the top candidates were selected to assess their compatibility with TRAF2. Pharmacological evaluation of the ligands was performed utilizing ADMET filters. Result: The compounds Resveratrol 4’-glucoside, Gnetin C, and Resveratrol 5-O-glucoside were identified as the most potential ROS for Colon Cancer treatment against the TRAF2 protein. Conclusion: All these bioactive substances are potential candidates for inhibiting colon cancer, given their significant binding affinity for the protein. Notably, among the top ligands, Resveratrol 4’-glucoside, Gnetin C, and Resveratrol 5-O-glucoside exhibited superior binding to the target protein.

Keywords: Colon malignancy, Stilbenes, TRAF2 protein.

[This article belongs to Research & Reviews : A Journal of Biotechnology (rrjobt)]

How to cite this article:
Aayushi Chaudhuri. Stilbenes: An emerging resource for Scavenging Reactive Oxygen Species in the field of Colon Malignancy. A molecular docking and ADMET Analysis approach.. Research & Reviews : A Journal of Biotechnology. 2024; 14(03):-.
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Aayushi Chaudhuri. Stilbenes: An emerging resource for Scavenging Reactive Oxygen Species in the field of Colon Malignancy. A molecular docking and ADMET Analysis approach.. Research & Reviews : A Journal of Biotechnology. 2024; 14(03):-. Available from: https://journals.stmjournals.com/rrjobt/article=2024/view=0

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Regular Issue Subscription Original Research
Volume 14
Issue 03
Received 02/09/2024
Accepted 24/10/2024
Published 06/11/2024
97

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