A Systematic Review of Method Development and Validation for Ramipril Analysis Using Hplc in Cardiovascular Research

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Year : August 14, 2024 at 12:17 pm | [if 1553 equals=””] Volume :15 [else] Volume :15[/if 1553] | [if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] : 02 | Page : –

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Devshree Yashwantbhai Patel, Dr. Javesh Kashinath Patil, Harsha Vasudev Chaudhari, Aniket Rajesing Girase,

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  1. Research Scholar, Associate Professor, Research Scholar, Research Scholar Department of Pharmaceutical Quality Assurance P.S.G.V.P. Mandal’s College of Pharmacy Shahada, Dist – Nandurbar ,425409, Department of Pharmaceutical Quality Assurance P.S.G.V.P. Mandal’s College of Pharmacy Shahada, Dist – Nandurbar ,425409, Department of Pharmaceutical Quality Assurance P.S.G.V.P. Mandal’s College of Pharmacy Shahada, Dist – Nandurbar ,425409, Department of Pharmaceutical Quality Assurance P.S.G.V.P. Mandal’s College of Pharmacy Shahada, Dist – Nandurbar ,425409 Maharashtra, Maharashtra, Maharashtra, Maharashtra India, India, India, India
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Abstract

nThe field of analytical chemistry encompasses a variety of methods that are crucial in determining the chemical composition of different substances. UV-visible spectroscopy and high-performance liquid chromatography (HPLC) are two widely utilized methods that are the subject of this article. UV-visible spectroscopy uses the Beer-Lambert law to quantify light absorption, which can provide information about the concentration of absorbing species. The method is based on how light and matter interact, with absorption occurring due to molecular electronic transitions. Conversely, high pressure is used in HPLC to separate mixture components according to how well they bind to a stationary phase. Its versatility stems from a variety of separation techniques, such as size exclusion chromatography, ion exchange, partition, and adsorption. Method development and validation are crucial to guaranteeing the dependability of analytical procedures. It is necessary to assess validation variables including specificity, accuracy, precision, linearity, and robustness to make sure a method is appropriate for the task at hand. Various HPLC techniques for the analysis of ramipril, an ACE inhibitor used to treat hypertension and heart failure, have been explored in the literature. These studies investigated different mobile phases and columns, demonstrating the flexibility of HPLC in pharmaceutical analysis. Ramipril works by blocking the renin-angiotensin-aldosterone system (RAAS), which reduces inflammation and vasoconstriction. This abstract provides an extensive review of analytical chemistry techniques, with special emphasis on their importance in pharmaceutical analysis and drug development.

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Keywords: Ramipril; Hypertension; Analytical method development; Method Validation; HPLC

n[if 424 equals=”Regular Issue”][This article belongs to Journal of Modern Chemistry & Chemical Technology(jomcct)]

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[/if 424][if 424 equals=”Special Issue”][This article belongs to Special Issue under section in Journal of Modern Chemistry & Chemical Technology(jomcct)][/if 424][if 424 equals=”Conference”]This article belongs to Conference [/if 424]

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How to cite this article: Devshree Yashwantbhai Patel, Dr. Javesh Kashinath Patil, Harsha Vasudev Chaudhari, Aniket Rajesing Girase. A Systematic Review of Method Development and Validation for Ramipril Analysis Using Hplc in Cardiovascular Research. Journal of Modern Chemistry & Chemical Technology. August 14, 2024; 15(02):-.

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How to cite this URL: Devshree Yashwantbhai Patel, Dr. Javesh Kashinath Patil, Harsha Vasudev Chaudhari, Aniket Rajesing Girase. A Systematic Review of Method Development and Validation for Ramipril Analysis Using Hplc in Cardiovascular Research. Journal of Modern Chemistry & Chemical Technology. August 14, 2024; 15(02):-. Available from: https://journals.stmjournals.com/jomcct/article=August 14, 2024/view=0

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[if 424 not_equal=””]Regular Issue[else]Published[/if 424] Subscription Review Article

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Journal of Modern Chemistry & Chemical Technology

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[if 344 not_equal=””]ISSN: 2229-6999[/if 344]

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Volume 15
[if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] 02
Received May 24, 2024
Accepted August 4, 2024
Published August 14, 2024

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