Nutraceutics: Opening the Debate for a Framework for the Safety and Efficacy of Nutraceuticals Formulations

Year : 2023 | Volume : 01 | Issue : 01 | Page : –
By

    MOHAMMAD NADEEM KHAN

Abstract

Currently, nutraceuticals do not have a clear and distinct definition that sets them apart from other
categories derived from food, such as food supplements, herbal products, pre- and probiotics,
functional foods, and fortified foods. Numerous studies have provided insights into the potential
mechanisms of action of pharmaceutically active components found in food, highlighting their capacity
to enhance health, mitigate the risk of pathological conditions, and contribute to overall well-being.
However, due to varying legislation across countries, nutraceuticals face challenges related to safety
and health claim substantiation. To address these challenges, it may be prudent for national competent
authorities to request manufacturers to furnish data supporting the safety, efficacy, and mechanism of
action for any claims on their product labels, particularly when using the term nutraceutical.
Implementing such measures could lead to improvements in the current regulatory landscape. The
future development of nutraceutical products holds promise for enhancing safety, efficacy, and
minimizing toxicity, offering a secure means to combat severe diseases. Despite existing gaps in the
understanding of nutraceuticals, individuals need to shift their mindset, prioritize concerns about side
effects, adverse reactions, and drug interactions, ultimately fostering a new paradigm of “Health for
All” through a novel approach to healthy living and dietary practices.

Keywords: Lifestyles, life-threatening diseases, awareness, nutraceuticals, traditional medicine, pharmacovigilance, safety

[This article belongs to Recent Trends in Infectious Diseases(rtid)]

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References

1. Chang HF, Yang LL. Gamma-mangostin, a micronutrient of mangosteen fruit, induces apoptosis
in human colon cancer cells. Molecules. 2012 Jul 3;17(7):8010-21.
2. Prinz-Langenohl R, Fohr I, Pietrzik K. Beneficial role for folate in the prevention of colorectal and
breast cancer. European journal of nutrition. 2001 Jun;40:98-105.
3. Modem S, DiCarlo SE, Reddy TR. Fresh garlic extract induces growth arrest and morphological
differentiation of MCF7 breast cancer cells. Genes & cancer. 2012 Feb;3(2):177-86.
4. Talib WH. Consumption of garlic and lemon aqueous extracts combination reduces tumor burden
by angiogenesis inhibition, apoptosis induction, and immune system modulation. Nutrition. 2017
Nov 1;43:89-97.
5. Vijayakumar S, Malaikozhundan B, Saravanakumar K, Durán-Lara EF, Wang MH, Vaseeharan B.
Garlic clove extract assisted silver nanoparticle–Antibacterial, antibiofilm, antihelminthic, antiinflammatory, anticancer and ecotoxicity assessment. Journal of Photochemistry and Photobiology
B: Biology. 2019 Sep 1;198:111558.
6. Kronski E, Fiori ME, Barbieri O, Astigiano S, Mirisola V, Killian PH, Bruno A, Pagani A, Rovera
F, Pfeffer U, Sommerhoff CP. miR181b is induced by the chemopreventive polyphenol curcumin
and inhibits breast cancer metastasis via down-regulation of the inflammatory cytokines CXCL1
and-2. Molecular oncology. 2014 May 1;8(3):581-95.
7. Simboli-Campbell M, Narvaez CJ, VanWeelden K, Tenniswood M, Welsh J. Comparative effects
of 1, 25 (OH) 2 D 3 and EB1089 on cell cycle kinetics and apoptosis in MCF-7 breast cancer cells.
Breast cancer research and treatment. 1997 Jan;42:31-41.
8. Wang Q, Lee D, Sysounthone V, Chandraratna RA, Christakos S, Korah R, Wieder R. 1, 25-
dihydroxyvitamin D3 and retonic acid analogues induce differentiation in breast cancer cells with
function-and cell-specific additive effects. Breast cancer research and treatment. 2001 May;67:
157-68.
9. Zhu X, Xiong L, Zhang X, Shi N, Zhang Y, Ke J, Sun Z, Chen T. Lyophilized strawberries prevent
7, 12-dimethylbenz [α] anthracene (DMBA)-induced oral squamous cell carcinogenesis in
hamsters. Journal of functional foods. 2015 May 1;15:476-86.
10. Petiwala SM, Johnson JJ. Diterpenes from rosemary (Rosmarinus officinalis): Defining their
potential for anti-cancer activity. Cancer letters. 2015 Oct 28;367(2):93-102.
11. Vinothkumar V, Manoharan S, Sindhu G, Nirmal MR, Vetrichelvi V. Geraniol modulates cell
proliferation, apoptosis, inflammation, and angiogenesis during 7, 12-dimethylbenz [a] anthraceneinduced hamster buccal pouch carcinogenesis. Molecular and cellular biochemistry. 2012
Oct;369:17-25.
12. Nair HB, Sung B, Yadav VR, Kannappan R, Chaturvedi MM, Aggarwal BB. Delivery of
antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer.
Biochemical pharmacology. 2010 Dec 15;80(12):1833-43.
13. Al-Okbi SY. Nutraceuticals of anti-inflammatory activity as complementary therapy for rheumatoid
arthritis. Toxicology and industrial health. 2014 Sep;30(8):738-49.
14. Vecchione R, Quagliariello V, Calabria D, Calcagno V, De Luca E, Iaffaioli RV, Netti PA.
Curcumin bioavailability from oil in water nano-emulsions: In vitro and in vivo study on the
dimensional, compositional and interactional dependence. Journal of Controlled Release. 2016 Jul
10;233:88-100.
15. Kunnumakkara AB, Bordoloi D, Padmavathi G, Monisha J, Roy NK, Prasad S, Aggarwal BB.
Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. British journal of
pharmacology. 2017 Jun;174(11):1325-48.
16. Panahi Y, Sahebkar A, Amiri M, Davoudi SM, Beiraghdar F, Hoseininejad SL, Kolivand M.
Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by
curcumin: results of a randomised, double-blind, placebo-controlled trial. British Journal of
Nutrition. 2012 Oct;108(7):1272-9.
17. Al Mijan M, Lim BO. Diets, functional foods, and nutraceuticals as alternative therapies for
inflammatory bowel disease: Present status and future trends. World journal of gastroenterology.
2018 Jul 7;24(25):2673.
18. Rodríguez-Cruz M, del Rocío Cruz-Guzmán O, Almeida-Becerril T, Solís-Serna AD, AtilanoMiguel S, Sánchez-González JR, Barbosa-Cortés L, Ruíz-Cruz ED, Huicochea JC, CárdenasConejo A, Escobar-Cedillo RE. Potential therapeutic impact of omega-3 long chainpolyunsaturated fatty acids on inflammation markers in Duchenne muscular dystrophy: A doubleblind, controlled randomized trial. Clinical Nutrition. 2018 Dec 1;37(6):1840-51.
19. Bansal P, Gupta SK, Ojha SK, Nandave M, Mittal R, Kumari S, Arya DS. Cardioprotective effect
of lycopene in the experimental model of myocardial ischemia-reperfusion injury. Molecular and
cellular biochemistry. 2006 Sep;289:1-9.
20. Ojha S, Goyal S, Sharma C, Arora S, Kumari S, Arya DS. Cardioprotective effect of lycopene
against isoproterenol-induced myocardial infarction in rats. Human & experimental toxicology.
2013 May;32(5):492-503.
21. Song B, Liu K, Gao Y, Zhao L, Fang H, Li Y, Pei L, Xu Y. Lycopene and risk of cardiovascular
diseases: A meta‐analysis of observational studies. Molecular nutrition & food research. 2017
Sep;61(9):1601009.
22. Srutkova D, Schwarzer M, Hudcovic T, Zakostelska Z, Drab V, Spanova A, Rittich B, Kozakova
H, Schabussova I. Bifidobacterium longum CCM 7952 promotes epithelial barrier function and
prevents acute DSS-induced colitis in strictly strain-specific manner. PloS one. 2015 Jul
28;10(7):e0134050..
23. Sichetti M, De Marco S, Pagiotti R, Traina G, Pietrella D. Anti-inflammatory effect of multistrain
probiotic formulation (L. rhamnosus, B. lactis, and B. longum). Nutrition. 2018 Sep 1;53:95-102.


Regular Issue Subscription Review Article
Volume 01
Issue 01
Received November 23, 2023
Accepted December 4, 2023
Published December 22, 2023

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