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Jaydatta Dhakane, Neha Patil, Shruti Adhikari, Himanshu Solanki, Nimisha Vala
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- PG Scholar, PG Scholar, PG Scholar, Associate Professor, Sister Tutor, SSR. College of Pharmacy, SSR. College of Pharmacy, SSR. College of Pharmacy, SSR. College of Pharmacy, Shri Vinoba Bhave College of Nursing, Dadra and Nagar Haveli, Daman & Diu, Dadra and Nagar Haveli, Daman & Diu, Dadra and Nagar Haveli, Daman & Diu, Dadra and Nagar Haveli, Daman & Diu, Dadra and Nagar Haveli, India, India, India, India, India
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Abstract
nPeptic ulcer disease is still a sincere gastrointestinal demand makes medication administration difficult because of the harsh and changing stomach environment. This paper investigates the potential of using mucoadhesive drug delivery devices to improve the accuracy and effectiveness of peptic ulcer therapies. Due to the inherent characteristics of mucoadhesive drug delivery systems, localized and sustained drug release is made possible by their extended contact and adherence to the gastrointestinal tract’s mucosal surfaces. These formulations can overcome the drawbacks of traditional administration techniques, such as quick evacuation and short residence times at the ulcer site, by taking use of their sticky qualities. This paper investigates the different mucoadhesive polymers used in peptic ulcer medication distribution, clarifying their adherence, biocompatibility, and formulation methods. Among other polymers, chitosan, alginate, and carbopol have exceptional mucoadhesive properties that allow them to stick to ulcerated mucosa and improve medication retention. The paper also covers the design concepts and developments in mucoadhesive formulations, such as site-specific delivery strategies, nanotechnology-based systems, and innovative drug carriers. These advancements seek to reduce systemic adverse effects, enhance bioavailability, and optimize medication release kinetics. We examine published studies and commercial formulations on mucoadhesive drug delivery devices for the treatment of peptic ulcers. This article’s conclusion emphasizes the revolutionary significance mucoadhesive drug delivery methods play in the treatment of peptic ulcers. It highlights their ability to get around delivery issues, improve therapeutic results, and perhaps transform treatment modalities for this common gastrointestinal illness.
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Keywords: Peptic Ulcer, Mucoadhesion, Mucoadhesive Polymers, Design, Application.
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References
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| Volume | 11 | |
| [if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] | 01 | |
| Received | March 16, 2024 | |
| Accepted | March 29, 2024 | |
| Published | April 30, 2024 |
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