Review On: Liquid Crystal Cream for Topical Drug Delivery

Year : 2024 | Volume :11 | Issue : 01 | Page : 1-8

Bhupendra M. Mahale

Sandip A.Tadavi

Sunil P. Pawar

  1. Research Scholar Kavayitri Bahinabai Chaudhari NMU University, P.S.G.V.P. Mandal’s College of Pharmacy Maharashtra India
  2. Associate Professor Kavayitri Bahinabai Chaudhari NMU University, P.S.G.V.P. Mandal’s College of Pharmacy Maharashtra India
  3. Principal P.S.G.V.P. Mandal’s College of Pharmacy Maharashtra India


A Liquid crystal creams represent a novel approach in skincare formulations, leveraging the unique properties of liquid crystal technology to improve skin hydration and barrier function. An overview of current developments in liquid crystal cream formulations is given in this article, with an emphasis on the benefits they offer for skincare and their composition and structure. Liquid crystal creams mimic the lipid bilayers of the skin, offering enhanced compatibility and permeability. Liquid crystal creams have emerged as a promising vehicle for topical drug delivery in pharmaceutical formulations, offering unique advantages for enhancing drug permeation, stability, and efficacy. This comprehensive review explores the application of liquid crystal technology in topical drug delivery systems, with a focus on composition, structure, and therapeutic applications. Liquid crystal creams, by mimicking the organization of biological membranes, facilitate the penetration of drugs across the skin barrier, resulting in improved bioavailability and therapeutic outcomes. Their versatile composition allows for the incorporation of à wide range of drugs, including hydrophilic and lipophilic compound, peptides, and proteins, enabling targeted delivery to specific skin layers or underlying tissues. Furthermore, the rheological properties of liquid crystal creams can be tailored to optimize drug release kinetics, providing sustained and controlled drug delivery over extended periods. Additionally, the incorporation of penetration enhancers and other excipients into liquid crystal creams can further enhance drug permeation and tissue targeting, expanding their potential applications in dermatology, cosmeceuticals, and wound healing. This review highlights the potential of liquid crystal creams as versatile and effective platforms for topical drug delivery in pharmaceutical formulations, with opportunities for continued research and development to optimize their performance and clinical utility.

Keywords: Liquid crystal, Cream, Skin, Topical drug delivery, Penetration, Bioavailability.

[This article belongs to Trends in Drug Delivery(tdd)]

How to cite this article: Bhupendra M. Mahale, Sandip A.Tadavi, Sunil P. Pawar. Review On: Liquid Crystal Cream for Topical Drug Delivery. Trends in Drug Delivery. 2024; 11(01):1-8.
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Regular Issue Subscription Review Article
Volume 11
Issue 01
Received March 14, 2024
Accepted April 1, 2024
Published April 30, 2024