Chenna M. Shalini
S. Anila
Rama Rao T.
- Associate Professor CMR College of Pharmacy Hyderabad, Telangana India
- Research Scholar CMR College of Pharmacy Hyderabad, Telangana India
- Principal CMR College of Pharmacy Hyderabad, Telangana India
Abstract
Non-steroidal anti-inflammatory drugs [NSAIDs]. are widely used for the management of pain, inflammation, and fever. However, their effectiveness is often limited by gastrointestinal side effects such as ulceration and bleeding, as well as systemic complications including renal toxicity and cardiovascular risks. To address these challenges, various strategies have been developed to improve the delivery of NSAIDs, aiming to enhance their therapeutic efficacy while minimizing adverse effects. This abstract provides an overview of recent advancements in NSAID delivery systems, including nanoparticle-based formulations, pro drug approaches, and targeted drug delivery strategies. Nanoparticle-based formulations offer advantages such as improved bioavailability, controlled release, and reduced toxicity profiles. Pro drugs of NSAIDs can undergo enzymatic conversion to the active drug at the site of inflammation, thereby minimizing systemic exposure and associated side effects. Targeted drug delivery systems enable site-specific accumulation of NSAIDs, thus maximizing therapeutic efficacy while minimizing off-target effects. Moreover, combination therapies involving NSAIDs and other pharmacological agents have emerged as promising approaches for synergistic effects and improved patient outcomes. Overall, the development of innovative drug delivery strategies holds great promise for optimizing the therapeutic potential of NSAIDs, paving the way for safer and more effective treatment options for patients with inflammatory conditions.
Keywords: Non-steroidal anti-inflammatory, Pro drugs, Controlled release, Synergistic effects, Analgesic medications.
[This article belongs to Trends in Drug Delivery(tdd)]
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References
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Trends in Drug Delivery
| Volume | 11 |
| Issue | 01 |
| Received | March 18, 2024 |
| Accepted | March 29, 2024 |
| Published | April 29, 2024 |