Revolutionizing Gastro-retentive Drug Delivery: Exploring Innovative Formulation Strategies and Mechanisms in Floating in Situ Gel Raft Forming System

Year : 2024 | Volume :11 | Issue : 01 | Page : –
By

Joel Pratapgadhwala

Dabbu Chauhan

Khushi Chauhan

Manashri Gondhalekar

Dr.Himanshu Solanki

  1. PG Scholar SSR College of Pharmacy Daman & Diu India
  2. PG Scholar SSR College of Pharmacy Daman & Diu India
  3. PG Scholar SSR College of Pharmacy Daman & Diu India
  4. PG Scholar SSR College of Pharmacy Daman & Diu India
  5. Associate Professor SSR College of Pharmacy Daman & Diu India

Abstract

An in-depth exploration of the transformative shift underway in gastro-retentive drug delivery, spotlighting the utilization of Floating Drug Delivery Systems (FDDS) and specifically honing in on the innovative formulation strategies and mechanisms inherent in Floating In Situ Gel Raft Forming Systems. FDDS present a promising avenue for revolutionizing drug delivery efficacy by capitalizing on buoyancy to float atop the gastric fluid surface, thereby extending gastric residence time and improving drug absorption. Particularly noteworthy within the realm of FDDS are raft-forming systems, distinguished by their ability to generate a cohesive gel layer in the stomach, which significantly contributes to the prolonged release kinetics of drugs, ultimately enhancing therapeutic outcomes. This review meticulously examines a spectrum of formulation strategies, encompassing polymer selection and drug incorporation techniques, all aimed at optimizing the performance of FDDS in drug delivery applications. Moreover, the review delves into the intricate mechanisms underlying buoyancy and elucidates the multifaceted factors influencing gastric retention, offering valuable insights into methods for fine-tuning drug release rates and thereby enhancing control over therapeutic outcomes. By comprehensively exploring the development and application of FDDS, this review serves as a foundational cornerstone in advancing the field of gastro-retentive drug delivery. It underscores the pivotal role of innovative formulation approaches in surmounting challenges associated with conventional drug delivery methods and highlights the potential of FDDS to address existing limitations and optimize drug delivery processes, thereby charting a path toward enhanced therapeutic efficacy and improved patient outcomes.

Keywords: GRDDS Approaches, Raft forming mechanism, Migrating myoelectric cycle, Gastric residence time, Polymers.

[This article belongs to Trends in Drug Delivery(tdd)]

How to cite this article: Joel Pratapgadhwala, Dabbu Chauhan, Khushi Chauhan, Manashri Gondhalekar, Dr.Himanshu Solanki. Revolutionizing Gastro-retentive Drug Delivery: Exploring Innovative Formulation Strategies and Mechanisms in Floating in Situ Gel Raft Forming System. Trends in Drug Delivery. 2024; 11(01):-.
How to cite this URL: Joel Pratapgadhwala, Dabbu Chauhan, Khushi Chauhan, Manashri Gondhalekar, Dr.Himanshu Solanki. Revolutionizing Gastro-retentive Drug Delivery: Exploring Innovative Formulation Strategies and Mechanisms in Floating in Situ Gel Raft Forming System. Trends in Drug Delivery. 2024; 11(01):-. Available from: https://journals.stmjournals.com/tdd/article=2024/view=143288


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Regular Issue Subscription Original Research
Volume 11
Issue 01
Received April 2, 2024
Accepted April 5, 2024
Published April 15, 2024