Amit Chawla
Payal Chawla
Arsh Chanana
Vikramjit Singh
- Principal Department of Pharmaceutical Sciences, Maa Saraswati Institute of Pharmaceutical Sciences, Abohar Punjab India
- Head Professor Department of Pharmaceutical Sciences, Maa Saraswati Institute of Pharmaceutical Sciences, Abohar Punjab India
- Assistant Professor Department of Pharmaceutical Sciences, Maa Saraswati Institute of Pharmaceutical Sciences, Abohar Punjab India
- Student Department of Pharmaceutical Sciences, Maa Saraswati Institute of Pharmaceutical Sciences, Abohar Punjab India
Abstract
Polymers that can degrade into biologically compatible components under physiologic conditions present a far more attractive alternative for the preparation of drug delivery systems. The use of biodegradable polymers precludes the need for retrieval at the conclusion of the dosing regimen, thereby avoiding the potential complications associated with the use of non-degradable systems. A wide variety of approaches are continuously being pursued in the quest for improved biodegradable drug delivery systems. New and modified polymer chemistries that offer distinctive degradation and drug delivery attributes are being identified and evaluated. At the same time, innovative engineering and manufacturing methods are under development to fabricate devices and physical platforms having novel three-dimensional structural attributes. In certain instances, these products make it possible to treat entirely new therapeutic applications using biodegradable devices.
Keywords: Biodegradable, polymers, drug delivery, biodegradation, physiologic
[This article belongs to Trends in Drug Delivery(tdd)]
Browse Figures
References
1. Swarbrick James. Encyclopedia of Pharmaceutical Technology. 3rd Edn. Vol. 1. Pinehurst, North Carolinia, USA: PharmaceuTech, Inc.; 2007; 176–190.
2. Chandra, Rustgi. Biodegradable polymers. Prog Polym Sci. Vol. 23. Great Britain: Elsevier Science Ltd.; 1998; 1273–1335.
3. Mitrus, et al. Biodegradable Polymers and Their Practical Utility. In Janssen Leon PBM, Leszek Moscicki, editors. Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA; 2009; 1–34.
4. Vroman, Tighzert. Biodegradable Polymers. Materials. 2009; 2(2): 307–344. Online at https://www.mdpi.com/1996-1944/2/2/307 [Access on 05-09-12].
5. Park, et al. Biodegradable Polymers for Microencapsulation of Drugs. Molecules. 2005; 10(1): 146–61.
6. Ikada and Tsuji. Biodegradable polyesters for medical and ecological applications. Macromol Rapid Commun. 2000; 21(3): 117–125.
7. Razak, et al. Biodegradable Polymers and their Bone Applications: A Review. Int J Basic Appl Sci. 2012; 12(01): 31–44.
8. Aggarwal, et al. Drug delivery: special emphasis given on biodegradable polymers. Advances in Polymer Science and Technology: An International Journal; Universal Research Publications. 2011; 2(1): 1–15.
9. Middleton, et al. Synthetic biodegradable polymers as orthopedic devices. Elsevier Science Ltd., Biomaterials. 2000; 21(23): 2335–2346.
10. Winzenburg, et al. Biodegradable polymers and their potential use in parenteral veterinary drug delivery systems. Adv Drug Deliv Rev, Elsevier. 2004; 56(10): 1453–66.
11. Guzman, et al. Biodegradable polymers for food packaging – factors influencing their degradation and certification types –a comprehensive review. Chem Chem Technol. 2011; 5(1): 115–118.
12. Wikipedia. Biodegradable Polymers. Online Available at < [Accessed on 30-05-21].
Trends in Drug Delivery
| Volume | 08 |
| Issue | 02 |
| Received | July 8, 2021 |
| Accepted | August 10, 2021 |
| Published | January 10, 2023 |