Navigating the Depths of Cancer Stem Cells: Unraveling Resistance Mechanisms and Emerging Therapeutic Strategies

Year : 2023 | Volume : 01 | Issue : 02 | Page : 14-18
By

    Gajanan Sapate

  1. Rutuja Shinde

  2. Swaraj Tawale

  3. Dipak Pawar

Abstract

In the past few decades, comprehensive evidence has convincingly established the presence of cancer stem cells (CSCs) as a minor subset within tumors, contributing to an unusually elevated level of cellular diversity within the malignancy. CSCs are functionally identified by their capacity for self-renewal and differentiation, frequently influenced by signals from their surrounding microenvironment. The interconnected transcriptional, post-transcriptional, metabolic, and epigenetic regulatory networks govern the biological characteristics of CSCs. CSCs contribute to tumor growth, therapeutic resistance, and disease recurrence by prolonged proliferation, invasion into normal tissue, angiogenesis enhancement, immune system evasion, and resistance to traditional anticancer therapy. As a result, understanding the molecular pathways behind cancer stem cell persistence, adaptability, and therapeutic resistance would increase our capacity to improve treatment.

Keywords: Cancer, Cancer stem cells, Tumor microenvironment, therapy resistance, Future perspectives.

[This article belongs to Recent Trends in Infectious Diseases(rtid)]

How to cite this article: Gajanan Sapate, Rutuja Shinde, Swaraj Tawale, Dipak Pawar Navigating the Depths of Cancer Stem Cells: Unraveling Resistance Mechanisms and Emerging Therapeutic Strategies rtid 2023; 01:14-18
How to cite this URL: Gajanan Sapate, Rutuja Shinde, Swaraj Tawale, Dipak Pawar Navigating the Depths of Cancer Stem Cells: Unraveling Resistance Mechanisms and Emerging Therapeutic Strategies rtid 2023 {cited 2023 Dec 30};01:14-18. Available from: https://journals.stmjournals.com/rtid/article=2023/view=130102

References

Huang T, Song X, Xu D, Tiek D, Goenka A, Wu B, Sastry N, Hu B, Cheng SY. Stem cell programs in cancer initiation, progression, and therapy resistance. Theranostics. 2020;10(19):8721.
Aramini B, Masciale V, Grisendi G, Bertolini F, Maur M, Guaitoli G, Chrystel I, Morandi U, Stella F, Dominici M, Haider KH. Dissecting tumor growth: The role of cancer stem cells in drug resistance and recurrence. Cancers. 2022 Feb 15;14(4):976.
Li Y, Wang Z, Ajani JA, Song S. Drug resistance and Cancer stem cells. Cell Communication and Signaling. 2021 Dec;19(1):1-1.
Abugomaa A, Elbadawy M, Yamawaki H, Usui T, Sasaki K. Emerging roles of cancer stem cells in bladder cancer progression, tumorigenesis, and resistance to chemotherapy: a potential therapeutic target for bladder cancer. Cells. 2020 Jan 17;9(1):235.
Das PK, Islam F, Lam AK. The roles of cancer stem cells and therapy resistance in colorectal carcinoma. Cells. 2020 Jun 3;9(6):1392.
Makena MR, Ranjan A, Thirumala V, Reddy AP. Cancer stem cells: Road to therapeutic resistance and strategies to overcome resistance. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2020 Apr 1;1866(4):165339.
Zhou HM, Zhang JG, Zhang X, Li Q. Targeting cancer stem cells for reversing therapy resistance: Mechanism, signaling, and prospective agents. Signal transduction and targeted therapy. 2021 Feb 15;6(1):62.
Oshimori N. Cancer stem cells and their niche in the progression of squamous cell carcinoma. Cancer science. 2020 Nov;111(11):3985-92.
Arnold CR, Mangesius J, Skvortsova II, Ganswindt U. The role of cancer stem cells in radiation resistance. Frontiers in oncology. 2020 Feb 20;10:164.
Jing N, Gao WQ, Fang YX. Regulation of formation, stemness, and therapeutic resistance of cancer stem cells. Frontiers in Cell and Developmental Biology. 2021 Apr 7;9:641498.
Gianì F, Vella V, Tumino D, Malandrino P, Frasca F. The possible role of cancer stem cells in the resistance to kinase inhibitors of advanced thyroid cancer. Cancers. 2020 Aug 11;12(8):2249.
Biserova K, Jakovlevs A, Uljanovs R, Strumfa I. Cancer stem cells: significance in origin, pathogenesis and treatment of glioblastoma. Cells. 2021 Mar 11;10(3):621.
Marzagalli M, Fontana F, Raimondi M, Limonta P. Cancer stem cells—Key players in tumor relapse. Cancers. 2021 Jan 20;13(3):376.
Ju F, Atyah MM, Horstmann N, Gul S, Vago R, Bruns CJ, Zhao Y, Dong QZ, Ren N. Characteristics of the cancer stem cell niche and therapeutic strategies. Stem Cell Research & Therapy. 2022 Dec;13(1):1-7.


Regular Issue Subscription Review Article
Volume 01
Issue 02
Received December 4, 2023
Accepted December 16, 2023
Published December 30, 2023