Assay of the Antitrypanosomal Activity of Ziingiber Officinale Extract in Wister Rats

Year : 2025 | Volume : 14 | Issue : 01 | Page : 32 37
    By

    Rufa’I F. A.,

  • Zakari A. I.,

  • Sani A.A.,

  • Umar A.,

  • Shu’aibu, M.,

  1. Researcher, Nigerian Institute for Trypanosomiasis (and Onchocerciasis) Research, Bayero University Kano, PMB 3011, Gwarzo Road, Kano, , Nigeria
  2. Researcher, Nigerian Institute for Trypanosomiasis (and onchocerciasis) Research, Kano Liasion office, Bayero University Kano, Gwarzo Road, Kano State, Nigeria
  3. Researcher, Nigerian Institute for Trypanosomiasis (and onchocerciasis) Research, Kano Liasion office, Bayero University Kano, Gwarzo Road, Kano State, Nigeria
  4. Researcher, Nigerian Institute for Trypanosomiasis (and onchocerciasis) Research, Kano Liasion office, Bayero University Kano, Gwarzo Road, Kano State, Nigeria
  5. Researcher, Nigerian Institute for Trypanosomiasis (and onchocerciasis) Research, Kano Liasion office, Bayero University Kano, Gwarzo Road, Kano State, Nigeria

Abstract

This research investigated the antitrypanosomal effects of Zingiber officinale in rats infected with Trypanosoma brucei brucei. Twelve adult rats, 7 weeks old and of both sexes, were randomly divided into six groups (1 through 6), with each group consisting of two rats. All six groups (1–6) were intraperitoneally injected with 0.1 ml of blood containing 10⁶ Trypanosomes/ml. Groups 1–4 received daily intraperitoneal doses of the plant extract at concentrations of 0.01, 0.1, 1.0, and 10 mg/ml/kg body weight, respectively. Group 5 was administered suramin, a standard anti-trypanosomal drug, at a dose of 7.86 mg/kg, serving as the positive control, while Group 6 remained untreated, acting as the negative control. Treatments were initiated four days after infection. The study evaluated physical and behavioral changes, along with hematological parameters. Phytochemical analysis revealed that Zingiber officinale contains saponins, tannins, glycosides, terpenoids, steroids, alkaloids, and flavonoids as major components. Acute toxicity tests suggested the plant is relatively safe. Rats treated with the plant extract displayed mild mucous membrane pallor, poor body condition, fever, lacrimation, aggression, and increased food intake. Furthermore, a significant reduction in mean PCV, Hgb, RBC, MCV, MCH, and MCHC values was observed in all groups treated with the extract compared to the suramin-treated group (P < 0.05).The study concluded that Zingiber officinale contains essential phytochemicals and bioactive compounds that are relatively safe and possess potent trypanocidal properties, making it a potential candidate for the treatment of trypanosomiasis

Keywords: Zingiber officinale, antitrypanosmal, Haematology, Suramin, lacrimation.

[This article belongs to Research and Reviews : Journal of Veterinary Science and Technology ]

How to cite this article:
Rufa’I F. A., Zakari A. I., Sani A.A., Umar A., Shu’aibu, M.. Assay of the Antitrypanosomal Activity of Ziingiber Officinale Extract in Wister Rats. Research and Reviews : Journal of Veterinary Science and Technology. 2025; 14(01):32-37.
How to cite this URL:
Rufa’I F. A., Zakari A. I., Sani A.A., Umar A., Shu’aibu, M.. Assay of the Antitrypanosomal Activity of Ziingiber Officinale Extract in Wister Rats. Research and Reviews : Journal of Veterinary Science and Technology. 2025; 14(01):32-37. Available from: https://journals.stmjournals.com/rrjovst/article=2025/view=197839


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Regular Issue Subscription Original Research
Volume 14
Issue 01
Received 18/01/2025
Accepted 03/02/2025
Published 12/02/2025
Publication Time 25 Days
287

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