Protective Effects of Phyllanthus amarus and Sida acuta Extracts Against DoxorubicinInduced Toxicity in Chick Embryo Models

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Year : 2025 | Volume : 15 | Issue : 02 | Page : –
    By

    Abhiruchi Sable,

  • Renu Shrivastava,

  • Rajendra Chauhan,

  1. Research Scholar, Department of Microbiology, Barkatullah University, Bhopal, Madhya Prodesh, India
  2. Assistant Professor, Department of Zoology Shri Sathya Sai College for Women, Bhopal, Madhya Pradesh, India
  3. Assistant Professor, Department of Zoology, Govt. MVM College, Bhopal, Madhya Pradesh, India

Abstract

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Chemotherapy remains a cornerstone of cancer treatment, yet severe side effects, including cardiotoxicity often limit its clinical application. Doxorubicin, a widely used anticancer drug, is particularly associated with dose-dependent toxicities that impact the heart, liver, and kidneys. In search of complementary approaches to mitigate these adverse effects, this study evaluates the protective potential of hydro-alcoholic extracts from Phyllanthus amarus and Sida acuta, two medicinal plants with known antioxidant and anti-inflammatory properties. Using the chick embryo model, a wellestablished and cost-effective system for studying developmental toxicology, this research investigates the effects of these plant extracts on Doxorubicin-induced toxicity.

The study involved administering Doxorubicin to developing chick embryos, with and without co-treatment of plant extracts. Biochemical assays assessed changes in toxicity markers, while histopathological analyses evaluated tissue damage in the heart, liver, and kidneys. Results revealed that embryos co-treated with the plant extracts showed significant reductions in toxicity markers, improved antioxidant enzyme activities, and preserved tissue integrity compared to the Doxorubicin-only group. These findings suggest that Phyllanthus amarus and Sida acuta can effectively mitigate oxidative stress and cellular damage induced by Doxorubicin.

This research highlights the potential of these medicinal plants as complementary agents to enhance the safety of chemotherapy. Their protective effects offer a promising alternative to conventional cardioprotective strategies, emphasizing the importance of integrating natural compounds into cancer treatment protocols. Further studies are recommended to explore their clinical applicability and molecular mechanisms, paving the way for novel therapeutic interventions that reduce chemotherapy-induced side effects while maintaining antitumor efficacy.

Keywords: Phyllanthus amarus, Sida acuta, Doxorubicin, cardiotoxicity, chick embryo model, phytotherapy, oxidative stress.

[This article belongs to Research and Reviews: A Journal of Toxicology ]

How to cite this article:
Abhiruchi Sable, Renu Shrivastava, Rajendra Chauhan. Protective Effects of Phyllanthus amarus and Sida acuta Extracts Against DoxorubicinInduced Toxicity in Chick Embryo Models. Research and Reviews: A Journal of Toxicology. 2025; 15(02):-.
How to cite this URL:
Abhiruchi Sable, Renu Shrivastava, Rajendra Chauhan. Protective Effects of Phyllanthus amarus and Sida acuta Extracts Against DoxorubicinInduced Toxicity in Chick Embryo Models. Research and Reviews: A Journal of Toxicology. 2025; 15(02):-. Available from: https://journals.stmjournals.com/rrjot/article=2025/view=0



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References

Regular Issue Subscription Review Article
Volume 15
Issue 02
Received 17/01/2025
Accepted 31/01/2025
Published 07/05/2025
Publication Time 110 Days
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