Overview of Diabetic Neuropathy: A Comprehensive Examination

Year : 2024 | Volume : | : | Page : –
By

Gyanendra Kumar Gupta

Gagan Devi

Abstract

Abstract: India has earned the unfortunate distinction of being the global epicenter for diabetes, with an alarming projection of 109 million individuals expected to be afflicted by the condition by 2035The global influence of diabetic neuropathy is significant, with an estimated 132 million individuals affected as of 2010, constituting roughly 1.9% of the global populace. Notably, within the diabetic population, there exists a significantly heightened prevalence The prevalence of sensory peripheral neuropathy stands at 60.4%, with an incidence rate of 8.76%. trend is particularly concerning as individuals age, with the likelihood of neuropathy increasing over time.The pervasive nature of this disease extends beyond national borders, presenting a burgeoning global challenge that profoundly influences daily life. The repercussions of diabetic neuropathy are multifaceted, encompassing sensory impairments, motor dysfunction, and an array of complications that compromise overall well-being. Tasks as seemingly mundane as walking, grasping objects, or even maintaining balance become formidable challenges for those affected. Moreover, the socioeconomic ramifications of diabetic neuropathy are substantial, as individuals contend with reduced productivity, increased healthcare expenditures, and diminished quality of life. Furthermore, the burden extends to caregivers and healthcare systems, amplifying the strain on resources and exacerbating healthcare disparities. Essentially, the widespread and increasing occurrence of diabetic neuropathy emphasizes the critical necessity for comprehensive approaches focused on preventing, detecting early, and managing it effectively. Addressing this multifaceted challenge demands a concerted global effort, encompassing research, policy initiatives, public awareness campaigns, and accessible 2 healthcare services. Only through collective action can we hope to mitigate the profound impact of this global health crisis and alleviate the suffering endured by millions worldwide

2
healthcare services. Only through
collective action can we hope to mitigate
the profound impact of this global health
crisis and alleviate the suffering endured

Keywords: Diabetes capital,Sensory peripheral neuropathy,Global problem .

How to cite this article: Gyanendra Kumar Gupta, Gagan Devi. Overview of Diabetic Neuropathy: A Comprehensive Examination. Research & Reviews: A Journal of Toxicology. 2024; ():-.
How to cite this URL: Gyanendra Kumar Gupta, Gagan Devi. Overview of Diabetic Neuropathy: A Comprehensive Examination. Research & Reviews: A Journal of Toxicology. 2024; ():-. Available from: https://journals.stmjournals.com/rrjot/article=2024/view=137124


References

1.Goldmamn’scecil medicine 24 th ed. By Saunders ,an imprint of Elsevier Copyright,2012
edited by Lee Goldman and Andrew I Schafer.
2.Indian Heart Association why south asians facts Web. 30 April 2015.
http://indianheartassociation.org/why-indians-why-south-asians/overview
3.Vos, T (Dec 15, 2012). “Years lived with disability (ylds) for 1160 sequelae of 289 diseases
and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.”
Lancet 380 (9859): 2163–96.
4.Battula P et al. International Journal of Research in Medical Sciences Int J Res Med Sci.
2017 Sep;5(9):4066-4071)
5.http://www.ncbi.nlm.nih.gov/pubmed/21274758
6. Pandit Hari Sadasiva Sastri Paradakara editor, Ashtanga Hridaya with the
commentaries Sarvangasundara of Arundatta and Ayurveda Rasayana of Hemadri,
Bhisagacarya; Nidansthan, Chapter 10, Verse 22, Chaukhamba Orientalia, Varanasi,
Reprint -2000, pg 321
7. Aacharya Vaidya Jadavaji Trikamji., editor. Agnivesha, Charaka, Charaka samhita,
Nidana Sthana, Adhyaya. Varanasi: Chaukhamba Sanskrit sansthan. 2nd ed. 47.
Vol. 4. Dridhabala. Varanasi: Chaukhamba Sanskrit sansthan; 1990. 325.
8Taber’s cyclopedic medical dictionary, 20 th edition, f.a.davis company, pg.no. 1462
9.Zeng L, Alongkronrusmee D, van Rijn RM. An integrated perspective on diabetic,
alcoholic, and drug-induced neuropathy, etiology, and treatment in the US. J Pain Res. 2017
Jan 20.
10:219-228.
10.Indian Heart Association why south asians facts Web. 30 April
2015.
11.http://indianheartassociation.org/why-indians-why-south-asians/overview
12.Vos, T (Dec 15, 2012). “Years lived with disability (ylds) for 1160 sequelae of 289
diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease
Study 2010.” Lancet 380 (9859): 2163–96.
13.International Journal of Research in Medical Sciences Battula P et al. Int J Res Med Sci.
2017 Sep;5(9):4066-4071
14. https://emedicine.medscape.com/article/1170337
15.Dorsey RR, Eberhardt MS, Gregg EW, Geiss LS. Control of risk factors among people
with diagnosed diabetes, by lower extremity disease status. Prev Chronic Dis. 2009 Oct.
6(4):A114
16.Tavakkoly-Bazzaz J, Amoli MM, Pravica V, Chandrasecaran R, Boulton AJ, Larijani B.
VEGF gene polymorphism association with diabetic neuropathy. Mol Biol Rep. 2010 Mar
30.
17.Diabetes control and complications trial research group. The effect of intensive treatment
of diabetes on the development and progression of long-term complications in insulin-
dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group.
N Engl J Med. 1993 Sep 30. 329(14):977-86
18.Harati Y. Diabetes and the nervous system. Endocrinal Metab Clin North Am. 1996 Jun.
25(2):325-59.
19.Rutkove SB. A 52-year-old woman with disabling peripheral neuropathy: review of
diabetic polyneuropathy. JAMA. 2009 Oct 7. 302(13):1451-8.
20.Jende JME, Groener JB, Oikonomou D, et al. Diabetic neuropathy differs between type 1
and type 2 diabetes Insights from magnetic resonance neurography. Ann Neurol. 2018 Feb
14.
21. Ryle C, Donaghy M. Non-enzymatic glycation of peripheral nerve proteins in human
diabetics. J Neurol Sci. 1995 Mar. 129(1):62-8
22.Figueroa-Romero C, Sadidi M, Feldman EL. Mechanisms of disease: The oxidative stress
theory of diabetic neuropathy. Rev Endocr Metab Disord. 2008 Dec. 9(4):301-14
23.American Diabetes Association. Standards of Medical Care in Diabetes—2009. Diabetes
Care. 2009;32:S13-61


Ahead of Print Subscription Review Article
Volume
Received February 5, 2024
Accepted February 9, 2024
Published March 30, 2024