Designing Aspects and Recent Advances in Digital Holographic Microscopy

Year : 2025 | Volume : 14 | Issue : 02 | Page : 06 18
    By

    Ritu Walia,

  • Kamal Nain Chopra,

  1. Associate Professor, Department of Physics, Maharaja Agrasen Institute of Technology, GGSIPU, Delhi, India
  2. Professor, Former Scientist G, Laser Science and Technology Center (LASTEC), DRDO, Metcalfe House, Delhi; and Former Research Scientist, Optoelectronics Lab, Department of Physics, Indian Institute of Technology, Hauz Khas,, Delhi, India

Abstract

Recent advances in Digital Holographic Microscopy have been discussed in this paper, besides throwing some light on the designing aspects of optical components like beam splitter and neutral density filter for the optimization of system performance. Some important related subtopics like spectral resolution of digital holograms, and Fourier-synthesis holography have been technically discussed. The optimization of acoustical holographic components for use in renewable energy production is presented in this study. The production of solar energy can be increased via holograms. It has been mentioned that the University of Michigan researchers in Arizona recently created a novel method for harnessing the excess solar energy utilized to light a solar panel. To achieve the most efficient light collecting, the holographic light collector’s optical element must be symmetrically positioned in the middle of the photovoltaic module. There has also been a qualitative analysis of some significant research on the subject, particularly in the fields of biology and medicine. It is anticipated that the work will be beneficial to digital holographic microscopy researchers and designers. Furthermore, the study emphasizes the interdisciplinary nature of holography, showing its potential not only in optical instrumentation but also in advanced biomedical imaging, tissue engineering, and drug monitoring. By improving image reconstruction algorithms and enhancing hardware design, digital holography could revolutionize non-invasive diagnostics and provide real-time cellular monitoring. Future research directions may focus on integrating artificial intelligence and machine learning for automated hologram interpretation, which can significantly reduce human error and increase system efficiency.

Keywords: Digital holographic microscopy, spectral resolution of digital holograms, single element reflective digital holographic microscopy, and fourier-synthesis holography

[This article belongs to Research & Reviews : Journal of Physics ]

How to cite this article:
Ritu Walia, Kamal Nain Chopra. Designing Aspects and Recent Advances in Digital Holographic Microscopy. Research & Reviews : Journal of Physics. 2025; 14(02):06-18.
How to cite this URL:
Ritu Walia, Kamal Nain Chopra. Designing Aspects and Recent Advances in Digital Holographic Microscopy. Research & Reviews : Journal of Physics. 2025; 14(02):06-18. Available from: https://journals.stmjournals.com/rrjophy/article=2025/view=224990


References

  1. Kühn J, Shaffer E, Mena J, Breton B, Parent J, Rappaz B, et al. Label-free cytotoxicity screening assay by digital holographic microscopy. Assay Drug Dev Technol. 2013;11(2):101–7.
  2. Rappaz B, Breton B, Shaffer E, Turcatti G. DHM: A quantitative label-free microscopy technique for phenotypic screening. Comb Chem High Throughput Screen. 2014;17:80–8.
  3. Jourdain P, Becq F, Lengacher S, Boinot C, Magistretti PJ, Marquet P. The human CFTR protein expressed in CHO cells activates aquaporin-3 in a cAMP-dependent pathway: study by digital holographic microscopy. J Cell Sci. 2014;127(3):546–56.
  4. Kumar M, Matoba O, Quan X, Rajput SK, Awatsuji Y, Tamada Y. Single-shot common-path off-axis digital holography: applications in bioimaging and optical metrology [Invited]. Appl Opt. 2021;60:A195.
  5. Nehmetallah G, Williams L, Nguyen T. Latest advances in single and multiwavelength digital holography and holographic microscopy. In: Augmented Reality. London: IntechOpen; 2020.
  6. Paturzo M, Pagliarulo V, Bianco V, Memmolo P, Miccio L, Merola F, et al. Digital holography, a metrological tool for quantitative analysis: trends and future applications. Opt Lasers Eng. 2018;104:32–47.
  7. Shimobaba T, Sato Y, Miura J, Takenouchi M, Ito T. Real-time digital holographic microscopy using the graphic processing unit. Opt Express. 2008;16:11776–81.
  8. Picazo-Bueno JA, Garcia-Monreal J, Serrano-Vicente M. Single-element reflective digital holographic microscopy. Front Phys. 2021;9:639607. doi:10.3389/fphy.2021.639607.
  9. Chopra KN, Maini AK. Thin Films and Their Applications in Military and Civil Sectors. New Delhi: Defence Science and Documentation Centre, DRDO, Ministry of Defence; 2010.
  10. Schnars U, Jüptner W. Digital Holography: Digital Hologram Recording, Numerical Reconstruction, and Related Techniques. Berlin: Springer; 2005.
  11. Warnasooriya N, Joud F, Bun P, Tessier G, Coppey-Moisan M, Desbiolles P, et al. Imaging gold nanoparticles in living cell environments using heterodyne digital holographic microscopy. Opt Express. 2010;18:3264–73.
  12. Jang J, Bae CY, Park J, Ye JC. Self-reference quantitative phase microscopy for microfluidic devices. Opt Lett. 2010;35:514–6.
  13. Di Caprio G, Gioffré M, Puglisi R, Balduzzi D, Galli A, Miccio L, et al. Digital self-referencing quantitative phase microscopy by wavefront folding in holographic image reconstruction. Opt Lett. 2010;35:3390–2.
  14. Miccio L, Grilli S, Paturzo M, Finizio A, Di Caprio G, Coppola G, et al. Quantitative phase contrast in holographic microscopy through the numerical manipulation of the retrieved wavefronts. In: Coherent Light Microscopy. Berlin: Springer; 2010.
  15. Di Caprio G, Coppola G, Wilding M, Ferraro P, Esposito G, Di Matteo L, et al. Digital holographic microscopy for the evaluation of human sperm structure. Zygote. 2014;22:446–54.
  16. Di Caprio G. Quantitative label-free cell imaging by means of digital holographic microscopy: a roadmap for a complete characterization of biological samples [PhD thesis]. Naples: University of Naples “Federico II”; 2011. Supervisor: Coppola G.
  17. Doblasa A, Sánchez-Ortiga E, Martínez-Corral M, Saavedra G, Andres P, Garcia-Sucerquia J. Curvature phase factor in digital holographic microscopy. Proc SPIE. 2013;8785:87856Q.
  18. Lee YL, Lin YC, Tu HY, Cheng CJ. Phase measurement accuracy in digital holographic microscopy using a wavelength-stabilized laser diode. J Opt. 2013;15(2):025403.
  19. Rappaz B, Breton B, Shaffer E, Turcatti G. Digital holographic microscopy: a quantitative label-free microscopy technique for phenotypic screening. Comb Chem High Throughput Screen. 2014;14:80–8.
  20. Yu X, Hong J, Liu C, Kim MK. Review of digital holographic microscopy for three-dimensional profiling and tracking. Opt Eng. 2014;53:112306.
  21. Schubert R, Vollmer A, Ketelhut S, Kemper B. Enhanced quantitative phase imaging in self-interference digital holographic microscopy using an electrically focus tunable lens. Biomed Opt Express. 2014;5:4213–22.
  22. Hazar IA, Dogar M, Özcan M. Digital holographic microscopy and focusing methods based on image sharpness. J Microsc. 2014;255:138–49.
  23. Colomb T, Charrière F, Kühn J, Marquet P, Depeursinge C. Advantages of digital holographic microscopy for real-time full-field absolute phase imaging. Available from: http://www.researchgate.net/publication/41939617
  24. Special Issue on Digital Holographic 3D Imaging: Capture, Display and Evaluation. ETRI J. 2019;41(Suppl 1):1–138.
  25. Tahara T, Quan X, Otani R, Takaki Y, Matoba O. Digital holography and its multidimensional imaging applications: a review. Microscopy. 2018;67(2):55–67.
  26. Solovyov AK, Pham HTT. Holographic optielements: advantages and disadvantages for efficient lighting, sun protection and photovoltaic power supply of buildings. Light Eng. 2021;29(5).
  27. Zhao J, Chrysler B, Kostuk RK. Holographic low concentration optical system increasing light collection efficiency of regular solar panels. J Photon Energy. 2021;11(2):027002.
  28. Ferrara MA, Borbone F, Coppola G. Holographic optical lenses recorded on a glassy matrix-based photopolymer for solar concentrators. Photonics. 2021;8(12):585.
Regular Issue Subscription Review Article
Volume 14
Issue 02
Received 20/03/2025
Accepted 08/05/2025
Published 25/08/2025
Publication Time 158 Days
96


My IP

PlumX Metrics